SARS-CoV-2 infection in patients with melanoma: results of the Spanish Melanoma Group registry

The Spanish Melanoma Group (GEM) developed a national registry of patients with melanoma infected by SARS-CoV-2 ("GRAVID"). The main objective was to describe the COVID-19 fatality rate in patients with melanoma throughout the pandemic, as well as to explore the effect of melanoma treatmen...

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Autores: Gonzalez-Cao, Maria, Puertolas, Teresa, Martinez-Vila, Clara, Carrera, Cristina, Maldonado Seral, Cayetana, Rodriguez-Jimenez, Pedro, Sequero, Silvia, Cerezuela-Fuentes, Pablo, Feltes Ochoa, Rosa, Muñoz, Eva, Antoñanzas Basa, Mónica, Martín-Liberal, Juan, Soria, Ainara, Rodriguez-Moreno, Juan Francisco, Marquez-Rodas, Ivan, Lopez Criado, Pilar, Manzano, José Luis, Lopez-Castro, Rafael, Ayala de Miguel, Pablo, Villalobos, Laura, Martin Algarra, Salvador, Gonzalez-Barrallo, Ines, Boada, Aram, García Castaño, Almudena, Puig, Susana, Crespo, Guillermo, Luna Fra, Pablo, Aguayo Zamora, Cristina, Feito Rodriguez, Marta, Valles, Lara, Drozdowskyj, Ana, Gardeazabal, Jesús, Fernandez-Morales, Luis Antonio, Rodrigo, Alberto, Cruz, Raquel, Yelamos, Oriol, Rubio, Belen, Mujica, Karmele, Provencio, Mariano, Berrocal, Alfonso
Tipo de recurso: artículo
Fecha de publicación:2023
País:España
Institución:Conselleria de Salut i Consum del Govern de les Illes Balears
Repositorio:Docusalut
Idioma:inglés
OAI Identifier:oai:docusalut.com:20.500.13003/18876
Acceso en línea:https://hdl.handle.net/20.500.13003/18876
Access Level:acceso abierto
Palabra clave:Child
Aged, 80 and over
Aged
Diabetes Mellitus
Young Adult
SARS-CoV-2
Adult
Humans
Adolescent
Melanoma
Middle Aged
Male
Female
COVID-19
Registries
Femenino
Adolescente
Masculino
Humanos
Persona de Mediana Edad
Adulto Joven
Anciano
Anciano de 80 o más Años
Niño
Adulto
Sistema de Registros
Descripción
Sumario:The Spanish Melanoma Group (GEM) developed a national registry of patients with melanoma infected by SARS-CoV-2 ("GRAVID"). The main objective was to describe the COVID-19 fatality rate in patients with melanoma throughout the pandemic, as well as to explore the effect of melanoma treatment and tumor stage on the risk of COVID-19 complications. These are the final data of the register, including cases from February 2020 to September 2021. One hundred-fifty cases were registered. Median age was 68 years (range 6-95), 61 (40%) patients were females, and 63 (42%) patients had stage IV. Thirty-nine (26%) were on treatment with immunotherapy, and 17 (11%) with BRAF-MEK inhibitors. COVID-19 was resolved in 119 cases, including 85 (57%) patients cured, 15 (10%) that died due to melanoma, and 20 (13%) that died due to COVID-19. Only age over 60 years, cardiovascular disorders, and diabetes mellitus increased the risk of death due to COVID-19, but not advanced melanoma stage nor melanoma systemic therapies. Three waves have been covered by the register: February-May 2020, August-November 2020, and December 2020-April 2021. The first wave had the highest number of registered cases and COVID-19 mortality. Tumor stage or melanoma treatments are non-significant prognostic factors for COVID-19 mortality. During the pandemic in Spain there was a downward trend in the number of patients registered across the waves, as well as in the severity of the infection. NCT04344002.

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