OncoNutridos study: Prevalence of disease-related malnutrition according to GLIM criteria in cancer patients in oncohaematology day hospitals

Background & aims: Disease-related malnutrition (DRM) is a frequent condition among cancer patients, with prevalence varying widely across studies depending on the phase of the disease (e.g., at diagnosis, during advanced stages, or throughout antineoplastic treatment) and tumour location. The a...

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Autores: Ripa, C, Olariaga, O, Vallinas, S, Sirvent, M, Prado, E, Romero, R, Perez, L, Terroba, P, Hernández, S, Chica, A, Gandara, MJ, Bourgon, L, Ochagavia, M, Tamayo, R, Leunda, L
Formato: artículo
Estado:Versión publicada
Fecha de publicación:2025
País:España
Recursos:Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana (FISABIO)
Repositorio:r-FISABIO. Repositorio Institucional de Producción Científica
OAI Identifier:oai:fisabio.fundanetsuite.com:p20292
Acesso em linha:https://fisabio.portalinvestigacion.com/publicaciones/20292
Access Level:acceso abierto
Palavra-chave:Oncology
Disease related malnutrition
GLIM criteria
Cancer
Survival
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dc.title.none.fl_str_mv OncoNutridos study: Prevalence of disease-related malnutrition according to GLIM criteria in cancer patients in oncohaematology day hospitals
title OncoNutridos study: Prevalence of disease-related malnutrition according to GLIM criteria in cancer patients in oncohaematology day hospitals
spellingShingle OncoNutridos study: Prevalence of disease-related malnutrition according to GLIM criteria in cancer patients in oncohaematology day hospitals
Ripa, C
Oncology
Disease related malnutrition
GLIM criteria
Cancer
Survival
title_short OncoNutridos study: Prevalence of disease-related malnutrition according to GLIM criteria in cancer patients in oncohaematology day hospitals
title_full OncoNutridos study: Prevalence of disease-related malnutrition according to GLIM criteria in cancer patients in oncohaematology day hospitals
title_fullStr OncoNutridos study: Prevalence of disease-related malnutrition according to GLIM criteria in cancer patients in oncohaematology day hospitals
title_full_unstemmed OncoNutridos study: Prevalence of disease-related malnutrition according to GLIM criteria in cancer patients in oncohaematology day hospitals
title_sort OncoNutridos study: Prevalence of disease-related malnutrition according to GLIM criteria in cancer patients in oncohaematology day hospitals
dc.creator.none.fl_str_mv Ripa, C
Olariaga, O
Vallinas, S
Sirvent, M
Prado, E
Romero, R
Perez, L
Terroba, P
Hernández, S
Chica, A
Gandara, MJ
Bourgon, L
Ochagavia, M
Tamayo, R
Leunda, L
author Ripa, C
author_facet Ripa, C
Olariaga, O
Vallinas, S
Sirvent, M
Prado, E
Romero, R
Perez, L
Terroba, P
Hernández, S
Chica, A
Gandara, MJ
Bourgon, L
Ochagavia, M
Tamayo, R
Leunda, L
author_role author
author2 Olariaga, O
Vallinas, S
Sirvent, M
Prado, E
Romero, R
Perez, L
Terroba, P
Hernández, S
Chica, A
Gandara, MJ
Bourgon, L
Ochagavia, M
Tamayo, R
Leunda, L
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Oncology
Disease related malnutrition
GLIM criteria
Cancer
Survival
topic Oncology
Disease related malnutrition
GLIM criteria
Cancer
Survival
description Background & aims: Disease-related malnutrition (DRM) is a frequent condition among cancer patients, with prevalence varying widely across studies depending on the phase of the disease (e.g., at diagnosis, during advanced stages, or throughout antineoplastic treatment) and tumour location. The aim of the OncoNutridos study was to assess the prevalence of DRM using the Global Leadership Initiative on Malnutrition (GLIM) criteria in cancer patients receiving active antineoplastic treatment in oncohaematology day hospitals. Additionally, the study evaluated the relationship between DRM and cancer-related hospital admissions, as well as 6-month mortality following study inclusion. Methods: This was a national, cross-sectional, observational, multicentre study conducted in accordance with standard clinical practice. Demographic characteristics, comorbidities, clinical variables, and anthropometric data were collected at the time of patient's admission to the chemotherapy suite. Anthropometric data -weight (kg) and height (m)- were obtained from the patient's medical record. Usual weight was obtained through patient's interview. DRM was diagnosed in accordance with the GLIM criteria. Reduced muscle mass was assessed via calf circumference -adjusted for the patient's BMI-. All patients were interviewed to detect reduced food intake. Patient recruitment took place across eight months, with a follow-up period of six months thereafter. Results: A total of 4440 patients were included between 86 hospitals nationwide. The median age was 61.1 years, 71.8 % of the patients were under 70 years of age, and 72.3 % were in advanced tumour stage (III-IV). The overall prevalence of disease-related malnutrition (DRM) according to GLIM criteria was 50.74 % (45.98 % in patients <70 years, and 62.86 % in those >= 70 years). Malnutrition prevalence was significantly higher among patients with advanced-stage tumours (stage III-IV) compared to those in early-stage disease (stage I-II) (54 % vs. 42 %; p < 0.001). Among patients with DRM, 72.52 % had moderate malnutrition, with no significant differences in malnutrition severity observed between age groups. Additionally, 77.2 % of malnourished patients were in advanced stages of disease (Stage III-IV). Compared to well-nourished individuals, malnourished patients had a significantly higher incidence of oncology-related hospitalizations in the six months following recruitment (36.8 % vs 31.32 %; p < 0.001; RR 1.18 IC95 % [1.08; 1.28]). Additionally, a higher percentage of deaths in the 6 months after the inclusion was detected in the group of patients with malnutrition (15.74 % vs 8.37 %; p < 0.001; RR 1.88 IC95 % [1.58; 2.23]). Conclusion: Given the high prevalence of malnutrition observed across all tumour types, cancer stages and age groups, early identification and timely nutritional intervention should be prioritized. The demonstrated impact of disease-related malnutrition on clinical outcomes underscores the need to integrate nutritional care as a key component of the comprehensive management of oncology patients. (c) 2025 The Authors. Published by Elsevier Ltd on behalf of European Society for Clinical Nutrition and Metabolism. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/ licenses/by-nc-nd/4.0/).
publishDate 2025
dc.date.none.fl_str_mv 2025
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info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://fisabio.portalinvestigacion.com/publicaciones/20292
url https://fisabio.portalinvestigacion.com/publicaciones/20292
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv ELSEVIER
publisher.none.fl_str_mv ELSEVIER
dc.source.none.fl_str_mv Clinical Nutrition ESPEN
ISSN: 24054577
reponame:r-FISABIO. Repositorio Institucional de Producción Científica
instname:Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana (FISABIO)
instname_str Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana (FISABIO)
reponame_str r-FISABIO. Repositorio Institucional de Producción Científica
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spelling OncoNutridos study: Prevalence of disease-related malnutrition according to GLIM criteria in cancer patients in oncohaematology day hospitalsRipa, COlariaga, OVallinas, SSirvent, MPrado, ERomero, RPerez, LTerroba, PHernández, SChica, AGandara, MJBourgon, LOchagavia, MTamayo, RLeunda, LOncologyDisease related malnutritionGLIM criteriaCancerSurvivalBackground & aims: Disease-related malnutrition (DRM) is a frequent condition among cancer patients, with prevalence varying widely across studies depending on the phase of the disease (e.g., at diagnosis, during advanced stages, or throughout antineoplastic treatment) and tumour location. The aim of the OncoNutridos study was to assess the prevalence of DRM using the Global Leadership Initiative on Malnutrition (GLIM) criteria in cancer patients receiving active antineoplastic treatment in oncohaematology day hospitals. Additionally, the study evaluated the relationship between DRM and cancer-related hospital admissions, as well as 6-month mortality following study inclusion. Methods: This was a national, cross-sectional, observational, multicentre study conducted in accordance with standard clinical practice. Demographic characteristics, comorbidities, clinical variables, and anthropometric data were collected at the time of patient's admission to the chemotherapy suite. Anthropometric data -weight (kg) and height (m)- were obtained from the patient's medical record. Usual weight was obtained through patient's interview. DRM was diagnosed in accordance with the GLIM criteria. Reduced muscle mass was assessed via calf circumference -adjusted for the patient's BMI-. All patients were interviewed to detect reduced food intake. Patient recruitment took place across eight months, with a follow-up period of six months thereafter. Results: A total of 4440 patients were included between 86 hospitals nationwide. The median age was 61.1 years, 71.8 % of the patients were under 70 years of age, and 72.3 % were in advanced tumour stage (III-IV). The overall prevalence of disease-related malnutrition (DRM) according to GLIM criteria was 50.74 % (45.98 % in patients <70 years, and 62.86 % in those >= 70 years). Malnutrition prevalence was significantly higher among patients with advanced-stage tumours (stage III-IV) compared to those in early-stage disease (stage I-II) (54 % vs. 42 %; p < 0.001). Among patients with DRM, 72.52 % had moderate malnutrition, with no significant differences in malnutrition severity observed between age groups. Additionally, 77.2 % of malnourished patients were in advanced stages of disease (Stage III-IV). Compared to well-nourished individuals, malnourished patients had a significantly higher incidence of oncology-related hospitalizations in the six months following recruitment (36.8 % vs 31.32 %; p < 0.001; RR 1.18 IC95 % [1.08; 1.28]). Additionally, a higher percentage of deaths in the 6 months after the inclusion was detected in the group of patients with malnutrition (15.74 % vs 8.37 %; p < 0.001; RR 1.88 IC95 % [1.58; 2.23]). Conclusion: Given the high prevalence of malnutrition observed across all tumour types, cancer stages and age groups, early identification and timely nutritional intervention should be prioritized. The demonstrated impact of disease-related malnutrition on clinical outcomes underscores the need to integrate nutritional care as a key component of the comprehensive management of oncology patients. (c) 2025 The Authors. Published by Elsevier Ltd on behalf of European Society for Clinical Nutrition and Metabolism. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/ licenses/by-nc-nd/4.0/).ELSEVIER2025info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttps://fisabio.portalinvestigacion.com/publicaciones/20292Clinical Nutrition ESPENISSN: 24054577reponame:r-FISABIO. Repositorio Institucional de Producción Científicainstname:Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana (FISABIO)Inglésinfo:eu-repo/semantics/openAccessoai:fisabio.fundanetsuite.com:p202922026-06-11T12:45:17Z
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