Malnutrition According to GLIM Criteria Is Associated with Mortality and Hospitalizations in Rehabilitation Patients with Stable Chronic Obstructive Pulmonary Disease

Malnutrition has a negative impact on patients with chronic pulmonary obstructive disease (COPD). The purpose of this study was to assess the prevalence of malnutrition, defined by the Global Leadership Initiative for Malnutrition (GLIM), in stable COPD patients referred to pulmonary rehabilitation,...

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Autores: Dávalos-Yerovi, Vanesa|||0000-0003-2676-5389, Marco, Ester|||0000-0002-3412-0356, Sánchez-Rodríguez, Dolores|||0000-0001-8662-5172, Duran-Jordà, Xavier|||0000-0001-8517-9254, Meza-Valderrama, Delky|||0000-0001-9259-7745, Rodríguez, Diego Agustín, Muñoz Gómez, Elena|||0000-0002-4869-1790, Tejero-Sánchez, Marta|||0000-0002-1904-456X, Muns Cornellas, Maria Dolors|||0000-0003-0248-0194, Guillén-Solà, Anna|||0000-0001-8442-8968, Duarte Oller, Esther|||0000-0002-4058-1802
Tipo de recurso: artículo
Fecha de publicación:2021
País:España
Institución:Universitat Autònoma de Barcelona
Repositorio:Dipòsit Digital de Documents de la UAB
Idioma:inglés
OAI Identifier:oai:ddd.uab.cat:252345
Acceso en línea:https://ddd.uab.cat/record/252345
https://dx.doi.org/urn:doi:10.3390/nu13020369
Access Level:acceso abierto
Palabra clave:Malnutrition
GLIM
Mortality
Hospitalization
Chronic pulmonary obstructive disease
Rehabilitation
Descripción
Sumario:Malnutrition has a negative impact on patients with chronic pulmonary obstructive disease (COPD). The purpose of this study was to assess the prevalence of malnutrition, defined by the Global Leadership Initiative for Malnutrition (GLIM), in stable COPD patients referred to pulmonary rehabilitation, and to explore potential associations of malnutrition according to GLIM, and its components, with increased risk of mortality and hospitalizations in 2 years. In a post-hoc analysis of a prospective cohort of 200 rehabilitation patients with stable COPD, main outcome variables were hospital admissions, length of stay, and mortality during a 2-year follow-up. Covariates were malnutrition according to GLIM and its phenotypic criteria: unintentional weight loss, low body mass index (BMI), and low fat-free mass (FFM). Univariate and multivariate analysis were performed using logistic and proportional hazard Cox regression. Malnutrition according to GLIM showed 45% prevalence and was associated with increased mortality risk. Low age-related BMI and FFM were independently associated with mortality, which persisted after adjustment for age and lung function. Malnutrition and low BMI were also associated with increased risk of hospitalization. Malnutrition according to GLIM criteria was highly prevalent in rehabilitation patients with COPD and was associated with nearly 3 times greater mortality and hospitalization risk.

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