Five genomic regions have a major impact on fat composition in Iberian pigs

The adipogenic nature of the Iberian pig defines many quality attributes of its fresh meat and dry-cured products. The distinct varieties of Iberian pig exhibit great variability in the genetic parameters for fat deposition and composition in muscle. The aim of this work is to identify common and di...

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Autores: Pena i Subirà, Ramona Natacha, Noguera Jiménez, José Luis, García-Santana, M. J., González, E., Tejeda, J. F., Ros Freixedes, Roger, Ibáñez-Escriche, N.
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2019
País:España
Institución:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositorio:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:10459.1/65962
Acceso en línea:https://doi.org/10.1038/s41598-019-38622-7
http://hdl.handle.net/10459.1/65962
Access Level:acceso abierto
Palabra clave:Porcs ibèrics
Carn de porc
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spelling Five genomic regions have a major impact on fat composition in Iberian pigsPena i Subirà, Ramona NatachaNoguera Jiménez, José LuisGarcía-Santana, M. J.González, E.Tejeda, J. F.Ros Freixedes, RogerIbáñez-Escriche, N.Porcs ibèricsCarn de porcThe adipogenic nature of the Iberian pig defines many quality attributes of its fresh meat and dry-cured products. The distinct varieties of Iberian pig exhibit great variability in the genetic parameters for fat deposition and composition in muscle. The aim of this work is to identify common and distinct genomic regions related to fatty acid composition in Retinto, Torbiscal, and Entrepelado Iberian varieties and their reciprocal crosses through a diallelic experiment. In this study, we performed GWAS using a high density SNP array on 382 pigs with the multimarker regression Bayes B method implemented in GenSel. A number of genomic regions showed strong associations with the percentage of saturated and unsaturated fatty acid in intramuscular fat. In particular, five regions with Bayes Factor >100 (SSC2 and SSC7) or >50 (SSC2 and SSC12) explained an important fraction of the genetic variance for miristic, palmitoleic, monounsaturated (>14%), oleic (>10%) and polyunsaturated (>5%) fatty acids. Six genes (RXRB, PSMB8, CHGA, ACACA, PLIN4, PLIN5) located in these regions have been investigated in relation to intramuscular composition variability in Iberian pigs, with two SNPs at the RXRB gene giving the most consistent results on oleic and monounsaturated fatty acid content.The authors would like to acknowledge the help of Inga Food S.A. and their support staff in setting up the experiment (E. Magallón, M. Ramos, L. Muñoz, and P. Diaz) and Dr L. Varona from University of Zaragoza for discussion. This study was funded by the INIA grant RTA 2012-0054-C02-01 and the Centre for the Development of Industrial Technology agreement IDI-20140447.Nature Research201920192019info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttps://doi.org/10.1038/s41598-019-38622-7http://hdl.handle.net/10459.1/65962http://hdl.handle.net/10459.1/65962reponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésReproducció del document publicat a: https://doi.org/10.1038/s41598-019-38622-7Scientific Reports, 2015, vol. 9, núm. 2031, p. 1-9cc-by, (c) Pena et al., 2019info:eu-repo/semantics/openAccesshttp://creativecommons.org/licenses/by/4.0/oai:recercat.cat:10459.1/659622026-05-29T05:05:01Z
dc.title.none.fl_str_mv Five genomic regions have a major impact on fat composition in Iberian pigs
title Five genomic regions have a major impact on fat composition in Iberian pigs
spellingShingle Five genomic regions have a major impact on fat composition in Iberian pigs
Pena i Subirà, Ramona Natacha
Porcs ibèrics
Carn de porc
title_short Five genomic regions have a major impact on fat composition in Iberian pigs
title_full Five genomic regions have a major impact on fat composition in Iberian pigs
title_fullStr Five genomic regions have a major impact on fat composition in Iberian pigs
title_full_unstemmed Five genomic regions have a major impact on fat composition in Iberian pigs
title_sort Five genomic regions have a major impact on fat composition in Iberian pigs
dc.creator.none.fl_str_mv Pena i Subirà, Ramona Natacha
Noguera Jiménez, José Luis
García-Santana, M. J.
González, E.
Tejeda, J. F.
Ros Freixedes, Roger
Ibáñez-Escriche, N.
author Pena i Subirà, Ramona Natacha
author_facet Pena i Subirà, Ramona Natacha
Noguera Jiménez, José Luis
García-Santana, M. J.
González, E.
Tejeda, J. F.
Ros Freixedes, Roger
Ibáñez-Escriche, N.
author_role author
author2 Noguera Jiménez, José Luis
García-Santana, M. J.
González, E.
Tejeda, J. F.
Ros Freixedes, Roger
Ibáñez-Escriche, N.
author2_role author
author
author
author
author
author
dc.subject.none.fl_str_mv Porcs ibèrics
Carn de porc
topic Porcs ibèrics
Carn de porc
description The adipogenic nature of the Iberian pig defines many quality attributes of its fresh meat and dry-cured products. The distinct varieties of Iberian pig exhibit great variability in the genetic parameters for fat deposition and composition in muscle. The aim of this work is to identify common and distinct genomic regions related to fatty acid composition in Retinto, Torbiscal, and Entrepelado Iberian varieties and their reciprocal crosses through a diallelic experiment. In this study, we performed GWAS using a high density SNP array on 382 pigs with the multimarker regression Bayes B method implemented in GenSel. A number of genomic regions showed strong associations with the percentage of saturated and unsaturated fatty acid in intramuscular fat. In particular, five regions with Bayes Factor >100 (SSC2 and SSC7) or >50 (SSC2 and SSC12) explained an important fraction of the genetic variance for miristic, palmitoleic, monounsaturated (>14%), oleic (>10%) and polyunsaturated (>5%) fatty acids. Six genes (RXRB, PSMB8, CHGA, ACACA, PLIN4, PLIN5) located in these regions have been investigated in relation to intramuscular composition variability in Iberian pigs, with two SNPs at the RXRB gene giving the most consistent results on oleic and monounsaturated fatty acid content.
publishDate 2019
dc.date.none.fl_str_mv 2019
2019
2019
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://doi.org/10.1038/s41598-019-38622-7
http://hdl.handle.net/10459.1/65962
http://hdl.handle.net/10459.1/65962
url https://doi.org/10.1038/s41598-019-38622-7
http://hdl.handle.net/10459.1/65962
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Reproducció del document publicat a: https://doi.org/10.1038/s41598-019-38622-7
Scientific Reports, 2015, vol. 9, núm. 2031, p. 1-9
dc.rights.none.fl_str_mv cc-by, (c) Pena et al., 2019
info:eu-repo/semantics/openAccess
http://creativecommons.org/licenses/by/4.0/
rights_invalid_str_mv cc-by, (c) Pena et al., 2019
http://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Nature Research
publisher.none.fl_str_mv Nature Research
dc.source.none.fl_str_mv reponame:Recercat. Dipósit de la Recerca de Catalunya
instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
instname_str Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
reponame_str Recercat. Dipósit de la Recerca de Catalunya
collection Recercat. Dipósit de la Recerca de Catalunya
repository.name.fl_str_mv
repository.mail.fl_str_mv
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