Effects of SHBG rs1799941 Polymorphism on Free Testosterone Levels and Hypogonadism Risk in Young Non-Diabetic Obese Males.

Obesity has been associated with increased risk of presenting hypogonadism. Free testosterone (FT) is the fraction of testosterone that carries out the biological function of testosterone, and is determined from total testosterone (TT) and sex-hormone binding globulin (SHBG) levels. We aimed to stud...

Descripción completa

Detalles Bibliográficos
Autores: Castellano-Castillo, Daniel, Royo, José Luis, Martínez-Escribano, Ana, Sánchez-Alcoholado, Lidia, Molina-Vega, María, Queipo-Ortuño, María Isabel, Ruiz-Galdon, Maximiliano, J Álvarez-Millán, Juan, Cabezas-Sanchez, Pablo, Reyes-Engel, Armando, Tinahones, Francisco J, Cardona, Fernando, Fernández-García, José Carlos
Tipo de recurso: artículo
Fecha de publicación:2019
País:España
Institución:Instituto de Salud Carlos III (ISCIII)
Repositorio:Repisalud
Idioma:inglés
OAI Identifier:oai:repisalud.isciii.es:20.500.12105/17894
Acceso en línea:http://hdl.handle.net/20.500.12105/17894
Access Level:acceso abierto
Palabra clave:SHBG
Free testosterone
Hypogonadism
Obesity
Polymorphism
rs1799941
id ES_d11ad3cd63d1d75bf1e9eaecb84d84ad
oai_identifier_str oai:repisalud.isciii.es:20.500.12105/17894
network_acronym_str ES
network_name_str España
repository_id_str
spelling Effects of SHBG rs1799941 Polymorphism on Free Testosterone Levels and Hypogonadism Risk in Young Non-Diabetic Obese Males.Castellano-Castillo, DanielRoyo, José LuisMartínez-Escribano, AnaSánchez-Alcoholado, LidiaMolina-Vega, MaríaQueipo-Ortuño, María IsabelRuiz-Galdon, MaximilianoJ Álvarez-Millán, JuanCabezas-Sanchez, PabloReyes-Engel, ArmandoTinahones, Francisco JCardona, FernandoFernández-García, José CarlosSHBGFree testosteroneHypogonadismObesityPolymorphismrs1799941Obesity has been associated with increased risk of presenting hypogonadism. Free testosterone (FT) is the fraction of testosterone that carries out the biological function of testosterone, and is determined from total testosterone (TT) and sex-hormone binding globulin (SHBG) levels. We aimed to study the SHBG polymorphism rs1799941 in a cohort of young non-diabetic obese males to unravel the possible implication of this polymorphism in obesity-related hypogonadism. 212 young ( 3.5 ng/mL and FT ≥ 70 pg/mL; EuG), normal FT hypogonadism (n = 40, TT The rs1799941 frequencies were different among the groups. Higher proportion of the allele (A) was found in HG, compared to EuG and normal FT HG. Among the genotypes, the rare homozygous (AA) were found in the normal FT HG group and higher levels of serum SHBG and lower of FT were observed. The presence of the allele A was related (according to lineal regression models) to an increased of SHBG levels ((GA) β = 3.28; (AA) β = 12.45) and a decreased of FT levels ((GA) β = -9.19; (AA) β = -18.52). The presence of the allele (A) increased the risk of presenting HG compared to normal FT HG (OR = 2.54). The rs1799941 of the SHBG gene can partially determine the presence of obesity-related hypogonadism in young non-diabetic males and whether these subjects have normal FT HG.20242024-02-1020192019-07-3120192019-07-31research articlehttp://purl.org/coar/resource_type/c_2df8fbb1VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articlehttp://hdl.handle.net/20.500.12105/17894reponame:Repisaludinstname:Instituto de Salud Carlos III (ISCIII)Inglésengopen accesshttp://purl.org/coar/access_right/c_abf2Attribution 4.0 Internationalhttp://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:repisalud.isciii.es:20.500.12105/178942026-06-12T12:43:37Z
dc.title.none.fl_str_mv Effects of SHBG rs1799941 Polymorphism on Free Testosterone Levels and Hypogonadism Risk in Young Non-Diabetic Obese Males.
title Effects of SHBG rs1799941 Polymorphism on Free Testosterone Levels and Hypogonadism Risk in Young Non-Diabetic Obese Males.
spellingShingle Effects of SHBG rs1799941 Polymorphism on Free Testosterone Levels and Hypogonadism Risk in Young Non-Diabetic Obese Males.
Castellano-Castillo, Daniel
SHBG
Free testosterone
Hypogonadism
Obesity
Polymorphism
rs1799941
title_short Effects of SHBG rs1799941 Polymorphism on Free Testosterone Levels and Hypogonadism Risk in Young Non-Diabetic Obese Males.
title_full Effects of SHBG rs1799941 Polymorphism on Free Testosterone Levels and Hypogonadism Risk in Young Non-Diabetic Obese Males.
title_fullStr Effects of SHBG rs1799941 Polymorphism on Free Testosterone Levels and Hypogonadism Risk in Young Non-Diabetic Obese Males.
title_full_unstemmed Effects of SHBG rs1799941 Polymorphism on Free Testosterone Levels and Hypogonadism Risk in Young Non-Diabetic Obese Males.
title_sort Effects of SHBG rs1799941 Polymorphism on Free Testosterone Levels and Hypogonadism Risk in Young Non-Diabetic Obese Males.
dc.creator.none.fl_str_mv Castellano-Castillo, Daniel
Royo, José Luis
Martínez-Escribano, Ana
Sánchez-Alcoholado, Lidia
Molina-Vega, María
Queipo-Ortuño, María Isabel
Ruiz-Galdon, Maximiliano
J Álvarez-Millán, Juan
Cabezas-Sanchez, Pablo
Reyes-Engel, Armando
Tinahones, Francisco J
Cardona, Fernando
Fernández-García, José Carlos
author Castellano-Castillo, Daniel
author_facet Castellano-Castillo, Daniel
Royo, José Luis
Martínez-Escribano, Ana
Sánchez-Alcoholado, Lidia
Molina-Vega, María
Queipo-Ortuño, María Isabel
Ruiz-Galdon, Maximiliano
J Álvarez-Millán, Juan
Cabezas-Sanchez, Pablo
Reyes-Engel, Armando
Tinahones, Francisco J
Cardona, Fernando
Fernández-García, José Carlos
author_role author
author2 Royo, José Luis
Martínez-Escribano, Ana
Sánchez-Alcoholado, Lidia
Molina-Vega, María
Queipo-Ortuño, María Isabel
Ruiz-Galdon, Maximiliano
J Álvarez-Millán, Juan
Cabezas-Sanchez, Pablo
Reyes-Engel, Armando
Tinahones, Francisco J
Cardona, Fernando
Fernández-García, José Carlos
author2_role author
author
author
author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv
dc.subject.none.fl_str_mv SHBG
Free testosterone
Hypogonadism
Obesity
Polymorphism
rs1799941
topic SHBG
Free testosterone
Hypogonadism
Obesity
Polymorphism
rs1799941
description Obesity has been associated with increased risk of presenting hypogonadism. Free testosterone (FT) is the fraction of testosterone that carries out the biological function of testosterone, and is determined from total testosterone (TT) and sex-hormone binding globulin (SHBG) levels. We aimed to study the SHBG polymorphism rs1799941 in a cohort of young non-diabetic obese males to unravel the possible implication of this polymorphism in obesity-related hypogonadism. 212 young ( 3.5 ng/mL and FT ≥ 70 pg/mL; EuG), normal FT hypogonadism (n = 40, TT The rs1799941 frequencies were different among the groups. Higher proportion of the allele (A) was found in HG, compared to EuG and normal FT HG. Among the genotypes, the rare homozygous (AA) were found in the normal FT HG group and higher levels of serum SHBG and lower of FT were observed. The presence of the allele A was related (according to lineal regression models) to an increased of SHBG levels ((GA) β = 3.28; (AA) β = 12.45) and a decreased of FT levels ((GA) β = -9.19; (AA) β = -18.52). The presence of the allele (A) increased the risk of presenting HG compared to normal FT HG (OR = 2.54). The rs1799941 of the SHBG gene can partially determine the presence of obesity-related hypogonadism in young non-diabetic males and whether these subjects have normal FT HG.
publishDate 2019
dc.date.none.fl_str_mv 2019
2019-07-31
2019
2019-07-31
2024
2024-02-10
dc.type.none.fl_str_mv research article
http://purl.org/coar/resource_type/c_2df8fbb1
VoR
http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv http://hdl.handle.net/20.500.12105/17894
url http://hdl.handle.net/20.500.12105/17894
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution 4.0 International
http://creativecommons.org/licenses/by/4.0/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution 4.0 International
http://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.source.none.fl_str_mv reponame:Repisalud
instname:Instituto de Salud Carlos III (ISCIII)
instname_str Instituto de Salud Carlos III (ISCIII)
reponame_str Repisalud
collection Repisalud
repository.name.fl_str_mv
repository.mail.fl_str_mv
_version_ 1869420233468411904
score 15,811543

Similares en LA Referencia