Dual role of Snail1 as transcriptional repressor and activator

Snail1 transcriptional factor plays a key role in the control of epithelial to mesenchymal transition, a process that remodels tumor cells increasing their invasion and chemo-resistance as well as reprograms their metabolism and provides stemness properties. During this transition, Snail1 acts as a...

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Detalhes bibliográficos
Autor: García de Herreros, Antonio
Tipo de documento: artigo
Estado:Versión aceptada para publicación
Data de publicação:2024
País:España
Recursos:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositório:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:10230/61507
Acesso em linha:http://hdl.handle.net/10230/61507
http://dx.doi.org/10.1016/j.bbcan.2023.189037
Access Level:Acceso aberto
Palavra-chave:EMT
Gene activation
Gene repression
Snail1
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spelling Dual role of Snail1 as transcriptional repressor and activatorGarcía de Herreros, AntonioEMTGene activationGene repressionSnail1Snail1 transcriptional factor plays a key role in the control of epithelial to mesenchymal transition, a process that remodels tumor cells increasing their invasion and chemo-resistance as well as reprograms their metabolism and provides stemness properties. During this transition, Snail1 acts as a transcriptional repressor and, as growing evidences have demonstrated, also as a direct activator of mesenchymal genes. In this review, I describe the different proteins that interact with Snail1 and are responsible for these two different functions on gene expression; I focus on the transcriptional factors that associate to Snail1 in their target promoters, both activated and repressed. I also present working models for Snail1 action both as repressor and activator and raise some issues that still need to be investigated.Work in my laboratory is supported by grants PID2019‐104698RB‐I00 and PID2022‐136968OB‐I00 funded by MCIN/AEI/10.13039/501100011033. I apologize if some Snail1 repression target, defined as indicated in Table 1, might have been unnoticed.Elsevier20242024info:eu-repo/semantics/articleinfo:eu-repo/semantics/acceptedVersionapplication/pdfapplication/pdfhttp://hdl.handle.net/10230/61507http://dx.doi.org/10.1016/j.bbcan.2023.189037reponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésBiochim Biophys Acta Rev Cancer. 2024 Jan;1879(1):189037info:eu-repo/grantAgreement/ES/2PE/PID2019-104698RB-I00info:eu-repo/grantAgreement/ES/3PE/PID2022-136968OB-I00© Elsevier http://dx.doi.org/10.1016/j.bbcan.2023.189037info:eu-repo/semantics/openAccessoai:recercat.cat:10230/615072026-05-29T05:05:01Z
dc.title.none.fl_str_mv Dual role of Snail1 as transcriptional repressor and activator
title Dual role of Snail1 as transcriptional repressor and activator
spellingShingle Dual role of Snail1 as transcriptional repressor and activator
García de Herreros, Antonio
EMT
Gene activation
Gene repression
Snail1
title_short Dual role of Snail1 as transcriptional repressor and activator
title_full Dual role of Snail1 as transcriptional repressor and activator
title_fullStr Dual role of Snail1 as transcriptional repressor and activator
title_full_unstemmed Dual role of Snail1 as transcriptional repressor and activator
title_sort Dual role of Snail1 as transcriptional repressor and activator
dc.creator.none.fl_str_mv García de Herreros, Antonio
author García de Herreros, Antonio
author_facet García de Herreros, Antonio
author_role author
dc.subject.none.fl_str_mv EMT
Gene activation
Gene repression
Snail1
topic EMT
Gene activation
Gene repression
Snail1
description Snail1 transcriptional factor plays a key role in the control of epithelial to mesenchymal transition, a process that remodels tumor cells increasing their invasion and chemo-resistance as well as reprograms their metabolism and provides stemness properties. During this transition, Snail1 acts as a transcriptional repressor and, as growing evidences have demonstrated, also as a direct activator of mesenchymal genes. In this review, I describe the different proteins that interact with Snail1 and are responsible for these two different functions on gene expression; I focus on the transcriptional factors that associate to Snail1 in their target promoters, both activated and repressed. I also present working models for Snail1 action both as repressor and activator and raise some issues that still need to be investigated.
publishDate 2024
dc.date.none.fl_str_mv 2024
2024
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/acceptedVersion
format article
status_str acceptedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10230/61507
http://dx.doi.org/10.1016/j.bbcan.2023.189037
url http://hdl.handle.net/10230/61507
http://dx.doi.org/10.1016/j.bbcan.2023.189037
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Biochim Biophys Acta Rev Cancer. 2024 Jan;1879(1):189037
info:eu-repo/grantAgreement/ES/2PE/PID2019-104698RB-I00
info:eu-repo/grantAgreement/ES/3PE/PID2022-136968OB-I00
dc.rights.none.fl_str_mv © Elsevier http://dx.doi.org/10.1016/j.bbcan.2023.189037
info:eu-repo/semantics/openAccess
rights_invalid_str_mv © Elsevier http://dx.doi.org/10.1016/j.bbcan.2023.189037
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:Recercat. Dipósit de la Recerca de Catalunya
instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
instname_str Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
reponame_str Recercat. Dipósit de la Recerca de Catalunya
collection Recercat. Dipósit de la Recerca de Catalunya
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,812429

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