Inflammatory agents partially explain associations between cortical thickness, surface area, and body mass in adolescents and young adulthood
Background/objectives Excessive body mass index (BMI) has been linked to a low-grade chronic inflammation state. Unhealthy BMI has also been related to neuroanatomical changes in adults. Research in adolescents is relatively limited and has produced conflicting results. This study aims to address th...
| Autores: | , , , , , , , , , , |
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| Tipo de recurso: | artículo |
| Estado: | Versión aceptada para publicación |
| Fecha de publicación: | 2020 |
| País: | España |
| Institución: | Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya) |
| Repositorio: | Recercat. Dipósit de la Recerca de Catalunya |
| OAI Identifier: | oai:recercat.cat:2445/164817 |
| Acceso en línea: | https://hdl.handle.net/2445/164817 |
| Access Level: | acceso abierto |
| Palabra clave: | Inflamació Escorça cerebral Pes corporal Adolescents Inflammation Cerebral cortex Body weight Teenagers |
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Inflammatory agents partially explain associations between cortical thickness, surface area, and body mass in adolescents and young adulthoodPrats Soteras, XavierJurado, Ma. Ángeles (María Ángeles)Ottino González, JonatanGarcía-García, IsabelSegura i Fàbregas, BàrbaraCaldú i Ferrús, XavierSánchez-Garre, ConsueloMiró, NúriaTor, C.Sender Palacios, María JoséGarolera i Freixa, MaiteInflamacióEscorça cerebralPes corporalAdolescentsInflammationCerebral cortexBody weightTeenagersBackground/objectives Excessive body mass index (BMI) has been linked to a low-grade chronic inflammation state. Unhealthy BMI has also been related to neuroanatomical changes in adults. Research in adolescents is relatively limited and has produced conflicting results. This study aims to address the relationship between BMI and adolescents'brain structure as well as to test the role that inflammatory adipose-related agents might have over this putative link. Methods We studied structural MRI and serum levels of interleukin-6, tumor necrosis factor alpha (TNF-α), C-reactive protein and fibrinogen in 65 adolescents (aged 12-21 years). Relationships between BMI, cortical thickness and surface area were tested with a vertex-wise analysis. Subsequently, we used backward multiple linear regression models to explore the influence of inflammatory parameters in each brain-altered area. Results We found a negative association between cortical thickness and BMI in the left lateral occipital cortex (LOC) and the right precentral gyrus as well as a positive relationship between surface area and BMI in the left rostral middle frontal gyrus and the right superior frontal gyrus. In addition, we found that higher fibrinogen serum concentrations were related to thinning within the left LOC (β=−0.45,p< 0.001), while higher serum levels of TNF-αwere associated to a greater surface area in the right superior frontal gyrus (β=0.32,p=0.045). Besides, we have also identified a trend that negatively correlates the cortical thickness of the left fusiform gyrus with the increases in BMI. It was also associated to fibrinogen(β=−0.33,p=0.035). Conclusions These results suggest that adolescents'body mass increases are related with brain abnormalities in areas that could play a relevant role in some aspects of feeding behavior. Likewise, we have evidenced that these cortical changes were partially explained by inflammatory agents such as fibrinogen and TNF-α.Nature Publishing Group2020202020202020info:eu-repo/semantics/articleinfo:eu-repo/semantics/acceptedVersionapplication/pdfapplication/pdfhttps://hdl.handle.net/2445/164817Articles publicats en revistes (Psicologia Clínica i Psicobiologia)reponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésVersió postprint del document publicat a: https://doi.org/10.1038/s41366-020-0582-yInternational Journal of Obesity, 2020https://doi.org/10.1038/s41366-020-0582-y(c) Prats-Soteras, X. et al., 2020info:eu-repo/semantics/openAccessoai:recercat.cat:2445/1648172026-05-29T05:05:01Z |
| dc.title.none.fl_str_mv |
Inflammatory agents partially explain associations between cortical thickness, surface area, and body mass in adolescents and young adulthood |
| title |
Inflammatory agents partially explain associations between cortical thickness, surface area, and body mass in adolescents and young adulthood |
| spellingShingle |
Inflammatory agents partially explain associations between cortical thickness, surface area, and body mass in adolescents and young adulthood Prats Soteras, Xavier Inflamació Escorça cerebral Pes corporal Adolescents Inflammation Cerebral cortex Body weight Teenagers |
| title_short |
Inflammatory agents partially explain associations between cortical thickness, surface area, and body mass in adolescents and young adulthood |
| title_full |
Inflammatory agents partially explain associations between cortical thickness, surface area, and body mass in adolescents and young adulthood |
| title_fullStr |
Inflammatory agents partially explain associations between cortical thickness, surface area, and body mass in adolescents and young adulthood |
| title_full_unstemmed |
Inflammatory agents partially explain associations between cortical thickness, surface area, and body mass in adolescents and young adulthood |
| title_sort |
Inflammatory agents partially explain associations between cortical thickness, surface area, and body mass in adolescents and young adulthood |
| dc.creator.none.fl_str_mv |
Prats Soteras, Xavier Jurado, Ma. Ángeles (María Ángeles) Ottino González, Jonatan García-García, Isabel Segura i Fàbregas, Bàrbara Caldú i Ferrús, Xavier Sánchez-Garre, Consuelo Miró, Núria Tor, C. Sender Palacios, María José Garolera i Freixa, Maite |
| author |
Prats Soteras, Xavier |
| author_facet |
Prats Soteras, Xavier Jurado, Ma. Ángeles (María Ángeles) Ottino González, Jonatan García-García, Isabel Segura i Fàbregas, Bàrbara Caldú i Ferrús, Xavier Sánchez-Garre, Consuelo Miró, Núria Tor, C. Sender Palacios, María José Garolera i Freixa, Maite |
| author_role |
author |
| author2 |
Jurado, Ma. Ángeles (María Ángeles) Ottino González, Jonatan García-García, Isabel Segura i Fàbregas, Bàrbara Caldú i Ferrús, Xavier Sánchez-Garre, Consuelo Miró, Núria Tor, C. Sender Palacios, María José Garolera i Freixa, Maite |
| author2_role |
author author author author author author author author author author |
| dc.subject.none.fl_str_mv |
Inflamació Escorça cerebral Pes corporal Adolescents Inflammation Cerebral cortex Body weight Teenagers |
| topic |
Inflamació Escorça cerebral Pes corporal Adolescents Inflammation Cerebral cortex Body weight Teenagers |
| description |
Background/objectives Excessive body mass index (BMI) has been linked to a low-grade chronic inflammation state. Unhealthy BMI has also been related to neuroanatomical changes in adults. Research in adolescents is relatively limited and has produced conflicting results. This study aims to address the relationship between BMI and adolescents'brain structure as well as to test the role that inflammatory adipose-related agents might have over this putative link. Methods We studied structural MRI and serum levels of interleukin-6, tumor necrosis factor alpha (TNF-α), C-reactive protein and fibrinogen in 65 adolescents (aged 12-21 years). Relationships between BMI, cortical thickness and surface area were tested with a vertex-wise analysis. Subsequently, we used backward multiple linear regression models to explore the influence of inflammatory parameters in each brain-altered area. Results We found a negative association between cortical thickness and BMI in the left lateral occipital cortex (LOC) and the right precentral gyrus as well as a positive relationship between surface area and BMI in the left rostral middle frontal gyrus and the right superior frontal gyrus. In addition, we found that higher fibrinogen serum concentrations were related to thinning within the left LOC (β=−0.45,p< 0.001), while higher serum levels of TNF-αwere associated to a greater surface area in the right superior frontal gyrus (β=0.32,p=0.045). Besides, we have also identified a trend that negatively correlates the cortical thickness of the left fusiform gyrus with the increases in BMI. It was also associated to fibrinogen(β=−0.33,p=0.035). Conclusions These results suggest that adolescents'body mass increases are related with brain abnormalities in areas that could play a relevant role in some aspects of feeding behavior. Likewise, we have evidenced that these cortical changes were partially explained by inflammatory agents such as fibrinogen and TNF-α. |
| publishDate |
2020 |
| dc.date.none.fl_str_mv |
2020 2020 2020 2020 |
| dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/acceptedVersion |
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article |
| status_str |
acceptedVersion |
| dc.identifier.none.fl_str_mv |
https://hdl.handle.net/2445/164817 |
| url |
https://hdl.handle.net/2445/164817 |
| dc.language.none.fl_str_mv |
Inglés |
| language_invalid_str_mv |
Inglés |
| dc.relation.none.fl_str_mv |
Versió postprint del document publicat a: https://doi.org/10.1038/s41366-020-0582-y International Journal of Obesity, 2020 https://doi.org/10.1038/s41366-020-0582-y |
| dc.rights.none.fl_str_mv |
(c) Prats-Soteras, X. et al., 2020 info:eu-repo/semantics/openAccess |
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(c) Prats-Soteras, X. et al., 2020 |
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openAccess |
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application/pdf application/pdf |
| dc.publisher.none.fl_str_mv |
Nature Publishing Group |
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Nature Publishing Group |
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Articles publicats en revistes (Psicologia Clínica i Psicobiologia) reponame:Recercat. Dipósit de la Recerca de Catalunya instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya) |
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Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya) |
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Recercat. Dipósit de la Recerca de Catalunya |
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Recercat. Dipósit de la Recerca de Catalunya |
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