Cortical thickness across the lifespan: Data from 17,075 healthy individuals aged 3–90 years

Delineating the association of age and cortical thickness in healthy individuals is critical given the association of cortical thickness with cognition and behavior. Previous research has shown that robust estimates of the association between age and brain morphometry require large-scale studies. In...

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Detalles Bibliográficos
Autores: Frangou, Sophia, Modabbernia, Amirhossein, Williams, Steven C. R., Papachristou, Efstathios, Doucet, Gaelle E., Agartz, Ingrid, Aghajani, Moji, Akudjedu, Theophilus N., Albajes Eizagirre, Anton, Alnæs, Dag, Alpert, Kathryn I., Jönsson, Erik G., Brandeis, Daniel, Breier, Alan, Glahn, David C., Brodaty, Henry, Hatton, Sean N., Mataix-Cols, David, Holmes, Avram J., Salvador, Raymond, Temmingh, Henk S., Zanetti, Marcus V., Haan, Lieuwe de, Brouwer, Rachel M., Andreassen, Ole A., Caseras, Xavier, Joska, John A., Castellanos, Francisco X., Cervenka, Simon, Chaim-Avancini, Tiffany M., Paloyelis, Yannis, Koops, Sanne, Naaijen, Jilly, Wang, Lei, Hosten, Norbert, Ching, Christopher R. K., Busatto, Geraldo F., Grabe, Hans Jörgen, Conzelmann, Annette, Sachdev, Perminder S., Zubicaray, Greig I., Mcdonald, Colm, Braber, Anouk, Najt, Pablo, Dickie, Erin W., Di Giorgio, Annabella, Satterthwaite, Theodore D., Doan, Nhat Trung, Rinker, Daniel A., Andreasen, Nancy C., Lebedeva, Irina, Dørum, Erlend S., Crone, Eveline A., Hoogman, Martine, Trollor, Julian N., Fatouros Bergman, Helena, Tamnes, Christian K., Grimm, Oliver, Ortiz García Foz, Víctor, Groenewold, Nynke A., Roffman, Joshua L., Grotegerd, Dominik, Gruber, Oliver, Tordesillas Gutiérrez, Diana, Gruner, Patricia, Nakao, Tomohiro, Soriano Mas, Carles, Pauli, Paul, Lee, Won Hee, Gur, Rachel E., Franke, Barbara, Lázaro García, Luisa, Wen, Wei, Heinz, Andreas, Walton, Esther, Howells, Fleur M., Völzke, Henry, Sarró, Salvador, Hulshoff Pol, Hilleke E., Stein, Dan J., Huyser, Chaim, Jahanshad, Neda, Weber, Bernd, James, Anthony, Rosa, Pedro G. P., Veer, Ilya M., Saykin, Andrew J., Buitelaar, Jan K., McIntosh, Andrew M., Jernigan, Terry L., Hickie, Ian B., Kalnin, Andrew, Bargalló Alabart, Núria, Kanai, Ryota, Andersson, Micael, Lesch, Klaus-Peter, Thompson, Paul M., Tomyshev, Alexander S., West, John D., Lochner, Christine, Veltman, Dick J., Machielsen, Marise W. J., Maingault, Sophie, Banaschewski, Tobias, Martin, Nicholas G., Strike, Lachlan T., Yoncheva, Yulyia, Turner, Jessica A., Crivello, Fabrice, Fouche, Jean Paul, Pergola, Giulio, Martínez Zalacaín, Ignacio, Koenders, Laura, McMahon, Katie L., Voineskos, Aristotle, McPhilemy, Genevieve, Menchón Magriñá, José Manuel, Medland, Sarah E., Calhoun, Vincent, Wassink, Thomas H., Hibar, Derrek P., Baumeister, Sarah, Meyer Lindenberg, Andreas, Mazoyer, Bernard, Serpa, Mauricio H., Nordvik, Jan E., Crespo Facorro, Benedicto, Pomarol-Clotet, Edith, Ziegler, Georg C., Portella, Maria J., Potkin, Steven G., Radua, Joaquim, Davey, Christopher, Asherson, Philip, Chubar, Victoria, Klyushnik, Tatyana P., Whalley, Heather, Reif, Andreas, Oosterlaan, Jaap, Uhlmann, Anne, Sacchet, Matthew D., Fisher, Simon E., Schmaal, Lianne, Buckner, Randy L., Schnell, Knut, Clark, Vincent P., Schumann, Gunter, Sim, Kang, Fuentes Claramonte, Paola, Smoller, Jordan W., Ehrlich, Stefan, Canales Rodríguez, Erick Jorge, Bertolino, Alessandro, Sommer, Iris, Sánchez Juan, Pascual, Westlye, Lars T., Hohmann, Sarah, Swagerman, Suzanne C., Heslenfeld, Dirk J., Heuvel, Odile A., Dale, Anders M., Meer, Dennis, Erk, Susanne, Wee, Nic J. A., Haren, Neeltje E. M., Hoekstra, Pieter J., Ent, Dennis, Conrod, Patricia, Gur, Ruben C., Geus, Eco J. C., Bonvino, Aurora, Erp, Theo G. M., Thomopoulos, Sophia I., Baur Streubel, Ramona, Kuntsi, Jonna, Walter, Henrik, Klein, Marieke, Wierenga, Lara M., Kahn, Rene, Frodl, Thomas, Wittfeld, Katharina, Harrison, Ben J., Wolf, Daniel H., Worker, Amanda, Krämer, Bernd, Wright, Margaret J., Espeseth, Thomas, Jiang, Jiyang, Gotlib, Ian H., Nyberg, Lars, Cannon, Dara M., Yang, Kun, Wang, Yang, Dima, Danai, Hartman, Catharine A., Karolinska Schizophrenia Project (KaSP), Boomsma, Dorret I., Borgwardt, Stefan, Mcdonald, Brenna C., Ho, Beng Choon, Lagopoulos, Jim, Bourque, Josiane
Tipo de recurso: artículo
Fecha de publicación:2021
País:España
Institución:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositorio:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:2445/174673
Acceso en línea:https://hdl.handle.net/2445/174673
Access Level:acceso abierto
Palabra clave:Escorça cerebral
Envelliment
Cerebral cortex
Aging
Descripción
Sumario:Delineating the association of age and cortical thickness in healthy individuals is critical given the association of cortical thickness with cognition and behavior. Previous research has shown that robust estimates of the association between age and brain morphometry require large-scale studies. In response, we used cross-sectional data from 17,075 individuals aged 3-90 years from the Enhancing Neuroimaging Genetics through Meta-Analysis (ENIGMA) Consortium to infer age-related changes in cortical thickness. We used fractional polynomial (FP) regression to quantify the association between age and cortical thickness, and we computed normalized growth centiles using the parametric Lambda, Mu, and Sigma method. Interindividual variability was estimated using meta-analysis and one-way analysis of variance. For most regions, their highest cortical thickness value was observed in childhood. Age and cortical thickness showed a negative association; the slope was steeper up to the third decade of life and more gradual thereafter; notable exceptions to this general pattern were entorhinal, temporopolar, and anterior cingulate cortices. Interindividual variability was largest in temporal and frontal regions across the lifespan. Age and its FP combinations explained up to 59% variance in cortical thickness. These results may form the basis of further investigation on normative deviation in cortical thickness and its significance for behavioral and cognitive outcomes.

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