Exosomal microRNAs isolated from plasma of mesenteric veins linked to liver metastases in resected patients with colon cancer

Before reaching a peripheral vein (PV), miRNAs released by the tumor are diluted and dispersed throughout the body or even retained in a specific organ. We hypothesized that blood drawn from the tumor-draining vein could provide more homogeneous information than blood drawn from the PV as that blood...

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Detalhes bibliográficos
Autores: Monzó Planella, Mariano, Santasusagna, Sandra, Moreno, Isabel, Martinez, Francisco, Hernández, Raquel, Muñoz, Carmen, Castellano, Joan Josep, Moreno, Josep, Navarro Ponz, Alfons
Formato: artículo
Estado:Versión publicada
Fecha de publicación:2017
País:España
Recursos:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositorio:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:2445/120996
Acesso em linha:https://hdl.handle.net/2445/120996
Access Level:acceso abierto
Palavra-chave:Càncer colorectal
Micro RNAs
Colorectal cancer
MicroRNAs
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spelling Exosomal microRNAs isolated from plasma of mesenteric veins linked to liver metastases in resected patients with colon cancerMonzó Planella, MarianoSantasusagna, SandraMoreno, IsabelMartinez, FranciscoHernández, RaquelMuñoz, CarmenCastellano, Joan JosepMoreno, JosepNavarro Ponz, AlfonsCàncer colorectalMicro RNAsColorectal cancerMicroRNAsBefore reaching a peripheral vein (PV), miRNAs released by the tumor are diluted and dispersed throughout the body or even retained in a specific organ. We hypothesized that blood drawn from the tumor-draining vein could provide more homogeneous information than blood drawn from the PV as that blood would contain all the biomarkers released by the tumor before they reach a potential metastatic site. We have profiled 754 miRNAs in 15 colon cancer plasma samples from the tumor-draining vein, the mesenteric vein (MV), identifying 13 microRNAs associated with relapse. The prognostic impact of these miRNAs were validated in 50 MV and 50 paired PV plasma samples of stage I-III colon cancer patients. Four miRNAs, let-7g, miR-15b, miR-155 and miR-328, were found overexpressed in MV compared to PV, and patients with high levels of those miRNAs in MV plasma had shorter time to relapse. Interestingly, in patients developing liver metastases, the exosomal cargo of miR-328 was much greater in MV than in PV plasma indicating a possible role of miR-328 in the development of liver metastases. Our results indicate that in colon cancer, the primary tumor releases high concentrations of miRNAs through the MV, and some of them are contained in tumor derived exosomes.Impact Journals2018201820172018info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion11 p.application/pdfapplication/pdfhttps://hdl.handle.net/2445/120996Articles publicats en revistes (Cirurgia i Especialitats Medicoquirúrgiques)reponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésReproducció del document publicat a: https://doi.org/10.18632/oncotarget.16103Oncotarget, 2017, vol. 8, num. 19, p. 30859-30869https://doi.org/10.18632/oncotarget.16103cc-by (c) Monzó Planella, Mariano et al., 2017http://creativecommons.org/licenses/by/3.0/esinfo:eu-repo/semantics/openAccessoai:recercat.cat:2445/1209962026-05-29T05:05:01Z
dc.title.none.fl_str_mv Exosomal microRNAs isolated from plasma of mesenteric veins linked to liver metastases in resected patients with colon cancer
title Exosomal microRNAs isolated from plasma of mesenteric veins linked to liver metastases in resected patients with colon cancer
spellingShingle Exosomal microRNAs isolated from plasma of mesenteric veins linked to liver metastases in resected patients with colon cancer
Monzó Planella, Mariano
Càncer colorectal
Micro RNAs
Colorectal cancer
MicroRNAs
title_short Exosomal microRNAs isolated from plasma of mesenteric veins linked to liver metastases in resected patients with colon cancer
title_full Exosomal microRNAs isolated from plasma of mesenteric veins linked to liver metastases in resected patients with colon cancer
title_fullStr Exosomal microRNAs isolated from plasma of mesenteric veins linked to liver metastases in resected patients with colon cancer
title_full_unstemmed Exosomal microRNAs isolated from plasma of mesenteric veins linked to liver metastases in resected patients with colon cancer
title_sort Exosomal microRNAs isolated from plasma of mesenteric veins linked to liver metastases in resected patients with colon cancer
dc.creator.none.fl_str_mv Monzó Planella, Mariano
Santasusagna, Sandra
Moreno, Isabel
Martinez, Francisco
Hernández, Raquel
Muñoz, Carmen
Castellano, Joan Josep
Moreno, Josep
Navarro Ponz, Alfons
author Monzó Planella, Mariano
author_facet Monzó Planella, Mariano
Santasusagna, Sandra
Moreno, Isabel
Martinez, Francisco
Hernández, Raquel
Muñoz, Carmen
Castellano, Joan Josep
Moreno, Josep
Navarro Ponz, Alfons
author_role author
author2 Santasusagna, Sandra
Moreno, Isabel
Martinez, Francisco
Hernández, Raquel
Muñoz, Carmen
Castellano, Joan Josep
Moreno, Josep
Navarro Ponz, Alfons
author2_role author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Càncer colorectal
Micro RNAs
Colorectal cancer
MicroRNAs
topic Càncer colorectal
Micro RNAs
Colorectal cancer
MicroRNAs
description Before reaching a peripheral vein (PV), miRNAs released by the tumor are diluted and dispersed throughout the body or even retained in a specific organ. We hypothesized that blood drawn from the tumor-draining vein could provide more homogeneous information than blood drawn from the PV as that blood would contain all the biomarkers released by the tumor before they reach a potential metastatic site. We have profiled 754 miRNAs in 15 colon cancer plasma samples from the tumor-draining vein, the mesenteric vein (MV), identifying 13 microRNAs associated with relapse. The prognostic impact of these miRNAs were validated in 50 MV and 50 paired PV plasma samples of stage I-III colon cancer patients. Four miRNAs, let-7g, miR-15b, miR-155 and miR-328, were found overexpressed in MV compared to PV, and patients with high levels of those miRNAs in MV plasma had shorter time to relapse. Interestingly, in patients developing liver metastases, the exosomal cargo of miR-328 was much greater in MV than in PV plasma indicating a possible role of miR-328 in the development of liver metastases. Our results indicate that in colon cancer, the primary tumor releases high concentrations of miRNAs through the MV, and some of them are contained in tumor derived exosomes.
publishDate 2017
dc.date.none.fl_str_mv 2017
2018
2018
2018
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/120996
url https://hdl.handle.net/2445/120996
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Reproducció del document publicat a: https://doi.org/10.18632/oncotarget.16103
Oncotarget, 2017, vol. 8, num. 19, p. 30859-30869
https://doi.org/10.18632/oncotarget.16103
dc.rights.none.fl_str_mv cc-by (c) Monzó Planella, Mariano et al., 2017
http://creativecommons.org/licenses/by/3.0/es
info:eu-repo/semantics/openAccess
rights_invalid_str_mv cc-by (c) Monzó Planella, Mariano et al., 2017
http://creativecommons.org/licenses/by/3.0/es
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 11 p.
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Impact Journals
publisher.none.fl_str_mv Impact Journals
dc.source.none.fl_str_mv Articles publicats en revistes (Cirurgia i Especialitats Medicoquirúrgiques)
reponame:Recercat. Dipósit de la Recerca de Catalunya
instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
instname_str Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
reponame_str Recercat. Dipósit de la Recerca de Catalunya
collection Recercat. Dipósit de la Recerca de Catalunya
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15.81155

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