Real-World Experience With Secukinumab for Hidradenitis Suppurativa: A Multicenter Retrospective Analysis of 263 Patients From the SECU-SPAIN Study

Background/objective: There is no consensus on the response rates of secukinumab, as findings from phase III trials differ from those reported in clinical-practice studies. This study aimed to assess the mid-term safety and efficacy profile of secukinumab in patients with moderate-to-severe Hidraden...

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Autores: Martorell, A, Vilarrasa-Rull, E, Fernandez-Crehuet, P, Molina-Leyva, A, Mansilla, M, Garcia-Ruiz, R, Garbayo-Salmons, P, Ortiz-Salvador, JM, Alfageme-Roldan, F, Garcias-Ladaria, J, Bassas-Vila, J, Fuertes-de-Vega, I, Carnero-Gonzalez, L, Almenara-Blasco, M, Torres-Navarro, I, Aguayo-Ortiz, R, Pallares, PG, Fornons-Servent, R, Gracia-Darder, I, Mora-Fernández, V, Corral, O, Pericet-Fernandez, L, Navarro, F, Haselgruber, S, Ochando-Ibernon, G, Menéndez-Parron, A, Masferrer, E, Gamissans, M, Solera-Talamante, M, Moya, M, Imbernon, A, Melgosa, J
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2026
País:España
Institución:Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana (FISABIO)
Repositorio:r-FISABIO. Repositorio Institucional de Producción Científica
OAI Identifier:oai:fisabio.fundanetsuite.com:p20201
Acceso en línea:https://fisabio.portalinvestigacion.com/publicaciones/20201
Access Level:acceso abierto
Palabra clave:HS
Secukinumab
Real-world evidence
Monoclonal antibody
Anti Il17A
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repository_id_str
spelling Real-World Experience With Secukinumab for Hidradenitis Suppurativa: A Multicenter Retrospective Analysis of 263 Patients From the SECU-SPAIN StudyMartorell, AVilarrasa-Rull, EFernandez-Crehuet, PMolina-Leyva, AMansilla, MGarcia-Ruiz, RGarbayo-Salmons, POrtiz-Salvador, JMAlfageme-Roldan, FGarcias-Ladaria, JBassas-Vila, JFuertes-de-Vega, ICarnero-Gonzalez, LAlmenara-Blasco, MTorres-Navarro, IAguayo-Ortiz, RPallares, PGFornons-Servent, RGracia-Darder, IMora-Fernández, VCorral, OPericet-Fernandez, LNavarro, FHaselgruber, SOchando-Ibernon, GMenéndez-Parron, AMasferrer, EGamissans, MSolera-Talamante, MMoya, MImbernon, AMelgosa, JHSSecukinumabReal-world evidenceMonoclonal antibodyAnti Il17ABackground/objective: There is no consensus on the response rates of secukinumab, as findings from phase III trials differ from those reported in clinical-practice studies. This study aimed to assess the mid-term safety and efficacy profile of secukinumab in patients with moderate-to-severe Hidradenitis suppurativa (HS). Methods: This retrospective, multicenter study included patients with moderate-to-severe HS treated with secuk inumab (300 mg every four weeks) between 2020 and 2024. Eligible patients were aged >= 18 years, with a clinical diagnosis of moderate-to-severe HS, and a minimum follow-up of 24 weeks. Key exclusions included patients treated with nonstandard secukinumab dosing regimens or those with insufficient clinical data. The primary endpoints were achievement of HiSCR50 (>= 50% reduction in the combined count of nodules and abscesses) at weeks 16 and 24). Secondary endpoints included achieving a >= 55% reduction in the International HS Severity Score (IHS4-55) and adverse events.<br /> Results: A total of 263 patients (49.4%, women; 50.6%, men; mean age, 41.8 +/- 13.2 years) were included. The most common HS phenotype was mixed (49.4%), and 55.1% had Hurley stage III disease. At weeks 16 and 24, a total of 57.4% and 63.6% of patients achieved HiSCR50, respectively. The mean IHS4 score dropped significantly from 16.7 +/- 10.0 at baseline to 7.6 +/- 5.6 at week 24 (p < 0.0001). At weeks 16 and 24, 52% and 56% of patients achieved an IHS4-55 response. Secukinumab was discontinued in 14.5% of patients because of lack of efficacy or adverse events. Conclusions: Secukinumab demonstrated a significant safety and efficacy profile for patients with moderate-to-severe in a real-world setting, with better outcomes than those reported in earlier clinical trials. Response evaluation at both week 16 and 24 is crucial due to variations in treatment effectiveness.ELSEVIER ESPANA2026info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttps://fisabio.portalinvestigacion.com/publicaciones/20201Actas Dermo-SifiliograficasISSN: 00017310ISSNe: 15782190reponame:r-FISABIO. Repositorio Institucional de Producción Científicainstname:Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana (FISABIO)Españolinfo:eu-repo/semantics/openAccessoai:fisabio.fundanetsuite.com:p202012026-06-11T12:45:17Z
dc.title.none.fl_str_mv Real-World Experience With Secukinumab for Hidradenitis Suppurativa: A Multicenter Retrospective Analysis of 263 Patients From the SECU-SPAIN Study
title Real-World Experience With Secukinumab for Hidradenitis Suppurativa: A Multicenter Retrospective Analysis of 263 Patients From the SECU-SPAIN Study
spellingShingle Real-World Experience With Secukinumab for Hidradenitis Suppurativa: A Multicenter Retrospective Analysis of 263 Patients From the SECU-SPAIN Study
Martorell, A
HS
Secukinumab
Real-world evidence
Monoclonal antibody
Anti Il17A
title_short Real-World Experience With Secukinumab for Hidradenitis Suppurativa: A Multicenter Retrospective Analysis of 263 Patients From the SECU-SPAIN Study
title_full Real-World Experience With Secukinumab for Hidradenitis Suppurativa: A Multicenter Retrospective Analysis of 263 Patients From the SECU-SPAIN Study
title_fullStr Real-World Experience With Secukinumab for Hidradenitis Suppurativa: A Multicenter Retrospective Analysis of 263 Patients From the SECU-SPAIN Study
title_full_unstemmed Real-World Experience With Secukinumab for Hidradenitis Suppurativa: A Multicenter Retrospective Analysis of 263 Patients From the SECU-SPAIN Study
title_sort Real-World Experience With Secukinumab for Hidradenitis Suppurativa: A Multicenter Retrospective Analysis of 263 Patients From the SECU-SPAIN Study
dc.creator.none.fl_str_mv Martorell, A
Vilarrasa-Rull, E
Fernandez-Crehuet, P
Molina-Leyva, A
Mansilla, M
Garcia-Ruiz, R
Garbayo-Salmons, P
Ortiz-Salvador, JM
Alfageme-Roldan, F
Garcias-Ladaria, J
Bassas-Vila, J
Fuertes-de-Vega, I
Carnero-Gonzalez, L
Almenara-Blasco, M
Torres-Navarro, I
Aguayo-Ortiz, R
Pallares, PG
Fornons-Servent, R
Gracia-Darder, I
Mora-Fernández, V
Corral, O
Pericet-Fernandez, L
Navarro, F
Haselgruber, S
Ochando-Ibernon, G
Menéndez-Parron, A
Masferrer, E
Gamissans, M
Solera-Talamante, M
Moya, M
Imbernon, A
Melgosa, J
author Martorell, A
author_facet Martorell, A
Vilarrasa-Rull, E
Fernandez-Crehuet, P
Molina-Leyva, A
Mansilla, M
Garcia-Ruiz, R
Garbayo-Salmons, P
Ortiz-Salvador, JM
Alfageme-Roldan, F
Garcias-Ladaria, J
Bassas-Vila, J
Fuertes-de-Vega, I
Carnero-Gonzalez, L
Almenara-Blasco, M
Torres-Navarro, I
Aguayo-Ortiz, R
Pallares, PG
Fornons-Servent, R
Gracia-Darder, I
Mora-Fernández, V
Corral, O
Pericet-Fernandez, L
Navarro, F
Haselgruber, S
Ochando-Ibernon, G
Menéndez-Parron, A
Masferrer, E
Gamissans, M
Solera-Talamante, M
Moya, M
Imbernon, A
Melgosa, J
author_role author
author2 Vilarrasa-Rull, E
Fernandez-Crehuet, P
Molina-Leyva, A
Mansilla, M
Garcia-Ruiz, R
Garbayo-Salmons, P
Ortiz-Salvador, JM
Alfageme-Roldan, F
Garcias-Ladaria, J
Bassas-Vila, J
Fuertes-de-Vega, I
Carnero-Gonzalez, L
Almenara-Blasco, M
Torres-Navarro, I
Aguayo-Ortiz, R
Pallares, PG
Fornons-Servent, R
Gracia-Darder, I
Mora-Fernández, V
Corral, O
Pericet-Fernandez, L
Navarro, F
Haselgruber, S
Ochando-Ibernon, G
Menéndez-Parron, A
Masferrer, E
Gamissans, M
Solera-Talamante, M
Moya, M
Imbernon, A
Melgosa, J
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv HS
Secukinumab
Real-world evidence
Monoclonal antibody
Anti Il17A
topic HS
Secukinumab
Real-world evidence
Monoclonal antibody
Anti Il17A
description Background/objective: There is no consensus on the response rates of secukinumab, as findings from phase III trials differ from those reported in clinical-practice studies. This study aimed to assess the mid-term safety and efficacy profile of secukinumab in patients with moderate-to-severe Hidradenitis suppurativa (HS). Methods: This retrospective, multicenter study included patients with moderate-to-severe HS treated with secuk inumab (300 mg every four weeks) between 2020 and 2024. Eligible patients were aged >= 18 years, with a clinical diagnosis of moderate-to-severe HS, and a minimum follow-up of 24 weeks. Key exclusions included patients treated with nonstandard secukinumab dosing regimens or those with insufficient clinical data. The primary endpoints were achievement of HiSCR50 (>= 50% reduction in the combined count of nodules and abscesses) at weeks 16 and 24). Secondary endpoints included achieving a >= 55% reduction in the International HS Severity Score (IHS4-55) and adverse events.<br /> Results: A total of 263 patients (49.4%, women; 50.6%, men; mean age, 41.8 +/- 13.2 years) were included. The most common HS phenotype was mixed (49.4%), and 55.1% had Hurley stage III disease. At weeks 16 and 24, a total of 57.4% and 63.6% of patients achieved HiSCR50, respectively. The mean IHS4 score dropped significantly from 16.7 +/- 10.0 at baseline to 7.6 +/- 5.6 at week 24 (p < 0.0001). At weeks 16 and 24, 52% and 56% of patients achieved an IHS4-55 response. Secukinumab was discontinued in 14.5% of patients because of lack of efficacy or adverse events. Conclusions: Secukinumab demonstrated a significant safety and efficacy profile for patients with moderate-to-severe in a real-world setting, with better outcomes than those reported in earlier clinical trials. Response evaluation at both week 16 and 24 is crucial due to variations in treatment effectiveness.
publishDate 2026
dc.date.none.fl_str_mv 2026
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://fisabio.portalinvestigacion.com/publicaciones/20201
url https://fisabio.portalinvestigacion.com/publicaciones/20201
dc.language.none.fl_str_mv Español
language_invalid_str_mv Español
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv ELSEVIER ESPANA
publisher.none.fl_str_mv ELSEVIER ESPANA
dc.source.none.fl_str_mv Actas Dermo-Sifiliograficas
ISSN: 00017310
ISSNe: 15782190
reponame:r-FISABIO. Repositorio Institucional de Producción Científica
instname:Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana (FISABIO)
instname_str Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana (FISABIO)
reponame_str r-FISABIO. Repositorio Institucional de Producción Científica
collection r-FISABIO. Repositorio Institucional de Producción Científica
repository.name.fl_str_mv
repository.mail.fl_str_mv
_version_ 1869420157900685312
score 15,811543

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