Real-World Experience With Secukinumab for Hidradenitis Suppurativa: A Multicenter Retrospective Analysis of 263 Patients From the SECU-SPAIN Study

Background/objective: There is no consensus on the response rates of secukinumab, as findings from phase III trials differ from those reported in clinical-practice studies. This study aimed to assess the mid-term safety and efficacy profile of secukinumab in patients with moderate-to-severe Hidraden...

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Detalles Bibliográficos
Autores: Martorell, A, Vilarrasa-Rull, E, Fernandez-Crehuet, P, Molina-Leyva, A, Mansilla, M, Garcia-Ruiz, R, Garbayo-Salmons, P, Ortiz-Salvador, JM, Alfageme-Roldan, F, Garcias-Ladaria, J, Bassas-Vila, J, Fuertes-de-Vega, I, Carnero-Gonzalez, L, Almenara-Blasco, M, Torres-Navarro, I, Aguayo-Ortiz, R, Pallares, PG, Fornons-Servent, R, Gracia-Darder, I, Mora-Fernández, V, Corral, O, Pericet-Fernandez, L, Navarro, F, Haselgruber, S, Ochando-Ibernon, G, Menéndez-Parron, A, Masferrer, E, Gamissans, M, Solera-Talamante, M, Moya, M, Imbernon, A, Melgosa, J
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2026
País:España
Institución:Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana (FISABIO)
Repositorio:r-FISABIO. Repositorio Institucional de Producción Científica
OAI Identifier:oai:fisabio.fundanetsuite.com:p20201
Acceso en línea:https://fisabio.portalinvestigacion.com/publicaciones/20201
Access Level:acceso abierto
Palabra clave:HS
Secukinumab
Real-world evidence
Monoclonal antibody
Anti Il17A
Descripción
Sumario:Background/objective: There is no consensus on the response rates of secukinumab, as findings from phase III trials differ from those reported in clinical-practice studies. This study aimed to assess the mid-term safety and efficacy profile of secukinumab in patients with moderate-to-severe Hidradenitis suppurativa (HS). Methods: This retrospective, multicenter study included patients with moderate-to-severe HS treated with secuk inumab (300 mg every four weeks) between 2020 and 2024. Eligible patients were aged >= 18 years, with a clinical diagnosis of moderate-to-severe HS, and a minimum follow-up of 24 weeks. Key exclusions included patients treated with nonstandard secukinumab dosing regimens or those with insufficient clinical data. The primary endpoints were achievement of HiSCR50 (>= 50% reduction in the combined count of nodules and abscesses) at weeks 16 and 24). Secondary endpoints included achieving a >= 55% reduction in the International HS Severity Score (IHS4-55) and adverse events.<br /> Results: A total of 263 patients (49.4%, women; 50.6%, men; mean age, 41.8 +/- 13.2 years) were included. The most common HS phenotype was mixed (49.4%), and 55.1% had Hurley stage III disease. At weeks 16 and 24, a total of 57.4% and 63.6% of patients achieved HiSCR50, respectively. The mean IHS4 score dropped significantly from 16.7 +/- 10.0 at baseline to 7.6 +/- 5.6 at week 24 (p < 0.0001). At weeks 16 and 24, 52% and 56% of patients achieved an IHS4-55 response. Secukinumab was discontinued in 14.5% of patients because of lack of efficacy or adverse events. Conclusions: Secukinumab demonstrated a significant safety and efficacy profile for patients with moderate-to-severe in a real-world setting, with better outcomes than those reported in earlier clinical trials. Response evaluation at both week 16 and 24 is crucial due to variations in treatment effectiveness.

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