Effectiveness of influenza vaccines in children aged 6 to 59 months: a test-negative case-control study at primary care and hospital level, Spain 2023/24

During 2023/24, all children aged 6 to 59 months were targeted for seasonal influenza vaccination in Spain nationally. Using a test-negative case-control design with sentinel surveillance data, we estimated adjusted influenza vaccine effectiveness (IVE) against any influenza type to be 70% (95% conf...

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Detalles Bibliográficos
Autores: Pérez-Gimeno, Gloria, Mazagatos, Clara, Lorusso, Nicola, Basile, Luca, Martínez-Pino, Isabel, Corpas-Burgos, Francisca, Batalla Rebolla, Noa, Rumayor-Zarzuelo, Mercedes Belén, Andreu Ivorra, Blanca, Giménez Duran, Jaume, Castrillejo, Daniel, Guiu Cañete, Inés, Huerta Huerta, Marta, García Becerril, Marta, Ramos Marín, Violeta, Casas Flecha, Inmaculada, Pozo Sanchez, Francisco, Monge Corella, Susana, SiVIRA group
Tipo de recurso: artículo
Fecha de publicación:2024
País:España
Institución:Instituto de Salud Carlos III (ISCIII)
Repositorio:Repisalud
Idioma:inglés
OAI Identifier:oai:repisalud.isciii.es:20.500.12105/25380
Acceso en línea:https://hdl.handle.net/20.500.12105/25380
Access Level:acceso abierto
Palabra clave:Children
Influenza
Test-negative design
Vaccine effectiveness
Case-Control Studies
Child, Preschool
Female
Hospitalization
Hospitals
Humans
Infant
Influenza A Virus, H1N1 Subtype
Influenza A Virus, H3N2 Subtype
Influenza B virus
Influenza Vaccines
Influenza, Human
Male
Primary Health Care
Seasons
Sentinel Surveillance
Spain
Vaccination
Vaccine Efficacy
Descripción
Sumario:During 2023/24, all children aged 6 to 59 months were targeted for seasonal influenza vaccination in Spain nationally. Using a test-negative case-control design with sentinel surveillance data, we estimated adjusted influenza vaccine effectiveness (IVE) against any influenza type to be 70% (95% confidence interval (CI): 51 to 81%) for primary care patients with acute respiratory illness (ARI) and 77% (95% CI: 21 to 93%) for hospitalised patients with severe ARI. In primary care, where most subtyped viruses (61%; 145/237) were A(H1N1), adjusted IVE was 77% (95% CI: 56 to 88%) against A(H1N1)pdm09.

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