Dietary intake of vitamin C and gastric cancer: a pooled analysis within the Stomach cancer Pooling (StoP) Project

BackgroundPrevious studies suggest that dietary vitamin C is inversely associated with gastric cancer (GC), but most of them did not consider intake of fruit and vegetables. Thus, we aimed to evaluate this association within the Stomach cancer Pooling (StoP) Project, a consortium of epidemiological...

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Autores: Sassano, M, Seyyedsalehi, MS, Collatuzzo, G, Pelucchi, C, Bonzi, R, Ferraroni, M, Palli, D, Yu, GP, Zhang, ZF, López-Carrillo, L, Lunet, N, Morais, S, Zaridze, D, Maximovich, D, Martín, V, Castano-Vinyals, G, Vioque, J, González-Palacios, S, Ward, MH, Malekzadeh, R, Pakseresht, M, Hernández-Ramirez, RU, López-Cervantes, M, Negri, E, Turati, F, Rabkin, CS, Tsugane, S, Hidaka, A, Lagiou, A, Lagiou, P, Camargo, MC, Curado, MP, Boccia, S, La Vecchia, C, Boffetta, P
Formato: artículo
Estado:Versión publicada
Fecha de publicación:2024
País:España
Recursos:Instituto de Investigación Biomédica y Sanitaria de Alicante (ISABIAL)
Repositorio:r-ISABIAL. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica y Sanitaria de Alicante
OAI Identifier:oai:isabial.fundanetsuite.com:p10183
Acesso em linha:https://isabial.portalinvestigacion.com/publicaciones10183
https://link.springer.com/article/10.1007/s10120-024-01476-8
Access Level:acceso abierto
Palavra-chave:Gastric cancer
Vitamin C
Diet
Pooled analysis
Consortium
Case-control
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spelling Dietary intake of vitamin C and gastric cancer: a pooled analysis within the Stomach cancer Pooling (StoP) ProjectSassano, MSeyyedsalehi, MSCollatuzzo, GPelucchi, CBonzi, RFerraroni, MPalli, DYu, GPZhang, ZFLópez-Carrillo, LLunet, NMorais, SZaridze, DMaximovich, DMartín, VCastano-Vinyals, GVioque, JGonzález-Palacios, SWard, MHMalekzadeh, RPakseresht, MHernández-Ramirez, RULópez-Cervantes, MNegri, ETurati, FRabkin, CSTsugane, SHidaka, ALagiou, ALagiou, PCamargo, MCCurado, MPBoccia, SLa Vecchia, CBoffetta, PGastric cancerVitamin CDietPooled analysisConsortiumCase-controlBackgroundPrevious studies suggest that dietary vitamin C is inversely associated with gastric cancer (GC), but most of them did not consider intake of fruit and vegetables. Thus, we aimed to evaluate this association within the Stomach cancer Pooling (StoP) Project, a consortium of epidemiological studies on GC.MethodsFourteen case-control studies were included in the analysis (5362 cases, 11,497 controls). We estimated odds ratios (ORs) and corresponding 95% confidence intervals (CIs) for the association between dietary intake of vitamin C and GC, adjusted for relevant confounders and for intake of fruit and vegetables. The dose-response relationship was evaluated using mixed-effects logistic models with second-order fractional polynomials.ResultsIndividuals in the highest quartile of dietary vitamin C intake had reduced odds of GC compared with those in the lowest quartile (OR: 0.64; 95% CI: 0.58, 0.72). Additional adjustment for fruit and vegetables intake led to an OR of 0.85 (95% CI: 0.73, 0.98). A significant inverse association was observed for noncardia GC, as well as for both intestinal and diffuse types of the disease. The results of the dose-response analysis showed decreasing ORs of GC up to 150-200 mg/day of vitamin C (OR: 0.54; 95% CI: 0.41, 0.71), whereas ORs for higher intakes were close to 1.0.ConclusionsThe findings of our pooled study suggest that vitamin C is inversely associated with GC, with a potentially beneficial effect also for intakes above the currently recommended daily intake (90 mg for men and 75 mg for women).SPRINGER2024info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttps://isabial.portalinvestigacion.com/publicaciones10183https://link.springer.com/article/10.1007/s10120-024-01476-8Gastric CancerISSN: 14363291ISSNe: 14363305reponame:r-ISABIAL. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica y Sanitaria de Alicanteinstname:Instituto de Investigación Biomédica y Sanitaria de Alicante (ISABIAL)Inglésinfo:eu-repo/semantics/openAccessoai:isabial.fundanetsuite.com:p101832026-06-12T10:20:37Z
dc.title.none.fl_str_mv Dietary intake of vitamin C and gastric cancer: a pooled analysis within the Stomach cancer Pooling (StoP) Project
title Dietary intake of vitamin C and gastric cancer: a pooled analysis within the Stomach cancer Pooling (StoP) Project
spellingShingle Dietary intake of vitamin C and gastric cancer: a pooled analysis within the Stomach cancer Pooling (StoP) Project
Sassano, M
Gastric cancer
Vitamin C
Diet
Pooled analysis
Consortium
Case-control
title_short Dietary intake of vitamin C and gastric cancer: a pooled analysis within the Stomach cancer Pooling (StoP) Project
title_full Dietary intake of vitamin C and gastric cancer: a pooled analysis within the Stomach cancer Pooling (StoP) Project
title_fullStr Dietary intake of vitamin C and gastric cancer: a pooled analysis within the Stomach cancer Pooling (StoP) Project
title_full_unstemmed Dietary intake of vitamin C and gastric cancer: a pooled analysis within the Stomach cancer Pooling (StoP) Project
title_sort Dietary intake of vitamin C and gastric cancer: a pooled analysis within the Stomach cancer Pooling (StoP) Project
dc.creator.none.fl_str_mv Sassano, M
Seyyedsalehi, MS
Collatuzzo, G
Pelucchi, C
Bonzi, R
Ferraroni, M
Palli, D
Yu, GP
Zhang, ZF
López-Carrillo, L
Lunet, N
Morais, S
Zaridze, D
Maximovich, D
Martín, V
Castano-Vinyals, G
Vioque, J
González-Palacios, S
Ward, MH
Malekzadeh, R
Pakseresht, M
Hernández-Ramirez, RU
López-Cervantes, M
Negri, E
Turati, F
Rabkin, CS
Tsugane, S
Hidaka, A
Lagiou, A
Lagiou, P
Camargo, MC
Curado, MP
Boccia, S
La Vecchia, C
Boffetta, P
author Sassano, M
author_facet Sassano, M
Seyyedsalehi, MS
Collatuzzo, G
Pelucchi, C
Bonzi, R
Ferraroni, M
Palli, D
Yu, GP
Zhang, ZF
López-Carrillo, L
Lunet, N
Morais, S
Zaridze, D
Maximovich, D
Martín, V
Castano-Vinyals, G
Vioque, J
González-Palacios, S
Ward, MH
Malekzadeh, R
Pakseresht, M
Hernández-Ramirez, RU
López-Cervantes, M
Negri, E
Turati, F
Rabkin, CS
Tsugane, S
Hidaka, A
Lagiou, A
Lagiou, P
Camargo, MC
Curado, MP
Boccia, S
La Vecchia, C
Boffetta, P
author_role author
author2 Seyyedsalehi, MS
Collatuzzo, G
Pelucchi, C
Bonzi, R
Ferraroni, M
Palli, D
Yu, GP
Zhang, ZF
López-Carrillo, L
Lunet, N
Morais, S
Zaridze, D
Maximovich, D
Martín, V
Castano-Vinyals, G
Vioque, J
González-Palacios, S
Ward, MH
Malekzadeh, R
Pakseresht, M
Hernández-Ramirez, RU
López-Cervantes, M
Negri, E
Turati, F
Rabkin, CS
Tsugane, S
Hidaka, A
Lagiou, A
Lagiou, P
Camargo, MC
Curado, MP
Boccia, S
La Vecchia, C
Boffetta, P
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Gastric cancer
Vitamin C
Diet
Pooled analysis
Consortium
Case-control
topic Gastric cancer
Vitamin C
Diet
Pooled analysis
Consortium
Case-control
description BackgroundPrevious studies suggest that dietary vitamin C is inversely associated with gastric cancer (GC), but most of them did not consider intake of fruit and vegetables. Thus, we aimed to evaluate this association within the Stomach cancer Pooling (StoP) Project, a consortium of epidemiological studies on GC.MethodsFourteen case-control studies were included in the analysis (5362 cases, 11,497 controls). We estimated odds ratios (ORs) and corresponding 95% confidence intervals (CIs) for the association between dietary intake of vitamin C and GC, adjusted for relevant confounders and for intake of fruit and vegetables. The dose-response relationship was evaluated using mixed-effects logistic models with second-order fractional polynomials.ResultsIndividuals in the highest quartile of dietary vitamin C intake had reduced odds of GC compared with those in the lowest quartile (OR: 0.64; 95% CI: 0.58, 0.72). Additional adjustment for fruit and vegetables intake led to an OR of 0.85 (95% CI: 0.73, 0.98). A significant inverse association was observed for noncardia GC, as well as for both intestinal and diffuse types of the disease. The results of the dose-response analysis showed decreasing ORs of GC up to 150-200 mg/day of vitamin C (OR: 0.54; 95% CI: 0.41, 0.71), whereas ORs for higher intakes were close to 1.0.ConclusionsThe findings of our pooled study suggest that vitamin C is inversely associated with GC, with a potentially beneficial effect also for intakes above the currently recommended daily intake (90 mg for men and 75 mg for women).
publishDate 2024
dc.date.none.fl_str_mv 2024
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://isabial.portalinvestigacion.com/publicaciones10183
https://link.springer.com/article/10.1007/s10120-024-01476-8
url https://isabial.portalinvestigacion.com/publicaciones10183
https://link.springer.com/article/10.1007/s10120-024-01476-8
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv SPRINGER
publisher.none.fl_str_mv SPRINGER
dc.source.none.fl_str_mv Gastric Cancer
ISSN: 14363291
ISSNe: 14363305
reponame:r-ISABIAL. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica y Sanitaria de Alicante
instname:Instituto de Investigación Biomédica y Sanitaria de Alicante (ISABIAL)
instname_str Instituto de Investigación Biomédica y Sanitaria de Alicante (ISABIAL)
reponame_str r-ISABIAL. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica y Sanitaria de Alicante
collection r-ISABIAL. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica y Sanitaria de Alicante
repository.name.fl_str_mv
repository.mail.fl_str_mv
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