Temperature modulates systemic and central actions of thyroid hormones on BAT thermogenesis

Thyroid hormones (THs) play a major role regulating energy balance and brown adipose tissue (BAT) thermogenesis, as well as body temperature, as shown in hyperthyroid patients. However, the current landscape of preclinical thyroid hormone models is complex. For example, while rats become catabolic a...

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Autores: Rial-Pensado, Eva, Rivas, Verónica, Grijota Martínez, María del Carmen, Rodríguez-Díaz, Amanda, Capelli, Valentina, Barca-Mayo, Olga, Nogueiras, Rubén, Mittag, Jens, Diéguez, Carlos, López, Miguel
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2022
País:España
Institución:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/291115
Acceso en línea:http://hdl.handle.net/10261/291115
Access Level:acceso abierto
Palabra clave:Thyroid hormones
Temperature
Thermogenesis
Brown adipose tissue
Hypothalamus
AMPK
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spelling Temperature modulates systemic and central actions of thyroid hormones on BAT thermogenesisRial-Pensado, EvaRivas, VerónicaGrijota Martínez, María del CarmenRodríguez-Díaz, AmandaCapelli, ValentinaBarca-Mayo, OlgaNogueiras, RubénMittag, JensDiéguez, CarlosLópez, MiguelThyroid hormonesTemperatureThermogenesisBrown adipose tissueHypothalamusAMPKThyroid hormones (THs) play a major role regulating energy balance and brown adipose tissue (BAT) thermogenesis, as well as body temperature, as shown in hyperthyroid patients. However, the current landscape of preclinical thyroid hormone models is complex. For example, while rats become catabolic after TH administration, mice gain weight; so, these differences in species need to be analyzed in detail and specially whether temperature could be a factor. Here, we aimed to investigate the effect of environmental temperature on those actions. Rats were subcutaneously treated with L-thyroxine (T4) or stereotaxically within the ventromedial nucleus of the hypothalamus (VMH) with triiodothyronine (T3) and housed at 23°C, 4°C or 30°C; energy balance, BAT thermogenesis and AMP-activated protein kinase (AMPK) in the VMH were analyzed. Our data showed that the effect of both systemic T4 of central T3 on energy balance and BAT thermogenesis was dependent upon environmental temperature. This evidence is of interest in the design of experimental settings highlighting the species-specific metabolic actions of THs, and in understanding its physiological role in the adaptation to temperature.This research was funded by: Ministerio de Ciencia y Universidades co-funded by the FEDER Program of EU (CD: BFU 2017-87721; RN: RTI 2018-099413-B-I00 and RED 2018-102379-T; ML: RTI 2018-101840-B-I00, PID2021-128145NB-I00 and PDC2022-133958-I00). “la Caixa” Foundation (ID100010434), under the agreement LCF/PR/HR19/52160022 (ML); European Research Council (RN: ERC Synergy Grant-2019-WATCH- 810331).Frontiers MediaMinisterio de Ciencia, Innovación y Universidades (España)Agencia Estatal de Investigación (España)Fundación la CaixaEuropean Research CouncilConsejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]2023202320222023info:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_6501Publisher's versioninfo:eu-repo/semantics/publishedVersionapplication/pdfhttp://hdl.handle.net/10261/291115reponame:DIGITAL.CSIC. Repositorio Institucional del CSICinstname:Consejo Superior de Investigaciones Científicas (CSIC)Inglés#PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE#info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/BFU2017-87721-Pinfo:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/RTI2018-099413-B-I00info:eu-repo/grantAgreement/AEI//RED 2018-102379-Tinfo:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/RTI2018-101840-B-I00info:eu-repo/grantAgreement/AEI//PID2021-128145NB-I00http://dx.doi.org/10.3389/fphys.2022.1017381Síinfo:eu-repo/semantics/openAccessoai:digital.csic.es:10261/2911152026-05-22T06:33:51Z
dc.title.none.fl_str_mv Temperature modulates systemic and central actions of thyroid hormones on BAT thermogenesis
title Temperature modulates systemic and central actions of thyroid hormones on BAT thermogenesis
spellingShingle Temperature modulates systemic and central actions of thyroid hormones on BAT thermogenesis
Rial-Pensado, Eva
Thyroid hormones
Temperature
Thermogenesis
Brown adipose tissue
Hypothalamus
AMPK
title_short Temperature modulates systemic and central actions of thyroid hormones on BAT thermogenesis
title_full Temperature modulates systemic and central actions of thyroid hormones on BAT thermogenesis
title_fullStr Temperature modulates systemic and central actions of thyroid hormones on BAT thermogenesis
title_full_unstemmed Temperature modulates systemic and central actions of thyroid hormones on BAT thermogenesis
title_sort Temperature modulates systemic and central actions of thyroid hormones on BAT thermogenesis
dc.creator.none.fl_str_mv Rial-Pensado, Eva
Rivas, Verónica
Grijota Martínez, María del Carmen
Rodríguez-Díaz, Amanda
Capelli, Valentina
Barca-Mayo, Olga
Nogueiras, Rubén
Mittag, Jens
Diéguez, Carlos
López, Miguel
author Rial-Pensado, Eva
author_facet Rial-Pensado, Eva
Rivas, Verónica
Grijota Martínez, María del Carmen
Rodríguez-Díaz, Amanda
Capelli, Valentina
Barca-Mayo, Olga
Nogueiras, Rubén
Mittag, Jens
Diéguez, Carlos
López, Miguel
author_role author
author2 Rivas, Verónica
Grijota Martínez, María del Carmen
Rodríguez-Díaz, Amanda
Capelli, Valentina
Barca-Mayo, Olga
Nogueiras, Rubén
Mittag, Jens
Diéguez, Carlos
López, Miguel
author2_role author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Ministerio de Ciencia, Innovación y Universidades (España)
Agencia Estatal de Investigación (España)
Fundación la Caixa
European Research Council
Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]
dc.subject.none.fl_str_mv Thyroid hormones
Temperature
Thermogenesis
Brown adipose tissue
Hypothalamus
AMPK
topic Thyroid hormones
Temperature
Thermogenesis
Brown adipose tissue
Hypothalamus
AMPK
description Thyroid hormones (THs) play a major role regulating energy balance and brown adipose tissue (BAT) thermogenesis, as well as body temperature, as shown in hyperthyroid patients. However, the current landscape of preclinical thyroid hormone models is complex. For example, while rats become catabolic after TH administration, mice gain weight; so, these differences in species need to be analyzed in detail and specially whether temperature could be a factor. Here, we aimed to investigate the effect of environmental temperature on those actions. Rats were subcutaneously treated with L-thyroxine (T4) or stereotaxically within the ventromedial nucleus of the hypothalamus (VMH) with triiodothyronine (T3) and housed at 23°C, 4°C or 30°C; energy balance, BAT thermogenesis and AMP-activated protein kinase (AMPK) in the VMH were analyzed. Our data showed that the effect of both systemic T4 of central T3 on energy balance and BAT thermogenesis was dependent upon environmental temperature. This evidence is of interest in the design of experimental settings highlighting the species-specific metabolic actions of THs, and in understanding its physiological role in the adaptation to temperature.
publishDate 2022
dc.date.none.fl_str_mv 2022
2023
2023
2023
dc.type.none.fl_str_mv info:eu-repo/semantics/article
http://purl.org/coar/resource_type/c_6501
Publisher's version
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10261/291115
url http://hdl.handle.net/10261/291115
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv #PLACEHOLDER_PARENT_METADATA_VALUE#
#PLACEHOLDER_PARENT_METADATA_VALUE#
#PLACEHOLDER_PARENT_METADATA_VALUE#
#PLACEHOLDER_PARENT_METADATA_VALUE#
#PLACEHOLDER_PARENT_METADATA_VALUE#
info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/BFU2017-87721-P
info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/RTI2018-099413-B-I00
info:eu-repo/grantAgreement/AEI//RED 2018-102379-T
info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/RTI2018-101840-B-I00
info:eu-repo/grantAgreement/AEI//PID2021-128145NB-I00
http://dx.doi.org/10.3389/fphys.2022.1017381
Sí
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Frontiers Media
publisher.none.fl_str_mv Frontiers Media
dc.source.none.fl_str_mv reponame:DIGITAL.CSIC. Repositorio Institucional del CSIC
instname:Consejo Superior de Investigaciones Científicas (CSIC)
instname_str Consejo Superior de Investigaciones Científicas (CSIC)
reponame_str DIGITAL.CSIC. Repositorio Institucional del CSIC
collection DIGITAL.CSIC. Repositorio Institucional del CSIC
repository.name.fl_str_mv
repository.mail.fl_str_mv
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