Temperature modulates systemic and central actions of thyroid hormones on BAT thermogenesis

Thyroid hormones (THs) play a major role regulating energy balance and brown adipose tissue (BAT) thermogenesis, as well as body temperature, as shown in hyperthyroid patients. However, the current landscape of preclinical thyroid hormone models is complex. For example, while rats become catabolic a...

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Bibliographic Details
Authors: Rial Pensado, Eva, Rivas Limeres, Verónica, Grijota Martínez, Carmen, Rodríguez Díaz, Amanda, Capelli, Vallentina, Barca Mayo, Olga, Nogueiras Pozo, Rubén, Mittag, Jens, Diéguez González, Carlos, López Pérez, Miguel A.
Format: article
Publication Date:2022
Country:España
Institution:Universidad de Santiago de Compostela (USC)
Repository:Minerva. Repositorio Institucional de la Universidad de Santiago de Compostela
Language:English
OAI Identifier:oai:minerva.usc.gal:10347/38692
Online Access:https://hdl.handle.net/10347/38692
Access Level:Open access
Keyword:Thyroid hormones
Temperature
Thermogenesis
Brown Adippose Tissue
Hypothalamus
AMPK
241104 Fisiología endocrina
241109 Regulación de la temperatura humana
Description
Summary:Thyroid hormones (THs) play a major role regulating energy balance and brown adipose tissue (BAT) thermogenesis, as well as body temperature, as shown in hyperthyroid patients. However, the current landscape of preclinical thyroid hormone models is complex. For example, while rats become catabolic after TH administration, mice gain weight; so, these differences in species need to be analyzed in detail and specially whether temperature could be a factor. Here, we aimed to investigate the effect of environmental temperature on those actions. Rats were subcutaneously treated with L-thyroxine (T4) or stereotaxically within the ventromedial nucleus of the hypothalamus (VMH) with triiodothyronine (T3) and housed at 23°C, 4°C or 30°C; energy balance, BAT thermogenesis and AMP-activated protein kinase (AMPK) in the VMH were analyzed. Our data showed that the effect of both systemic T4 of central T3 on energy balance and BAT thermogenesis was dependent upon environmental temperature. This evidence is of interest in the design of experimental settings highlighting the species-specific metabolic actions of THs, and in understanding its physiological role in the adaptation to temperature.

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