Effect of Dietary Supplementation with a Natural Extract of Sclerocarya birrea on Glycemic Metabolism in Subjects with Prediabetes: A Randomized Double-Blind Placebo-Controlled Study
A randomized, double-blind, placebo-controlled study was conducted with the primary objective of assessing the effect of a natural extract of Sclerocarya birrea on glucose metabolism in subjects with prediabetes. The duration of the study was 90 days. Thirty-three subjects assigned to the experiment...
| Autores: | , , , , , , , , |
|---|---|
| Formato: | artículo |
| Fecha de publicación: | 2021 |
| País: | España |
| Recursos: | Universidad Católica San Antonio de Murcia (UCAM) |
| Repositorio: | RIUCAM. Repositorio Institucional de la Universidad Católica San Antonio de Murcia |
| OAI Identifier: | oai:repositorio.ucam.edu:10952/8005 |
| Acesso em linha: | http://hdl.handle.net/10952/8005 |
| Access Level: | acceso abierto |
| Palavra-chave: | Sclerocarya birrea Nutraceutical product Clinical trial Lipid profile Insulin resistance Glucose metabolism Prediabetes |
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Effect of Dietary Supplementation with a Natural Extract of Sclerocarya birrea on Glycemic Metabolism in Subjects with Prediabetes: A Randomized Double-Blind Placebo-Controlled StudyVictoria Montesinos, DesiréeSánchez Macarro, MaravillasGabaldón, José AntonioAbellán Ruiz, María SaludQuerol Calderón, MaríaLuque Rubia, Antonio J.Bernal Morell, EnriqueÁvila Gandía, VicenteLópez Román, Francisco JavierSclerocarya birreaNutraceutical productClinical trialLipid profileInsulin resistanceGlucose metabolismPrediabetesA randomized, double-blind, placebo-controlled study was conducted with the primary objective of assessing the effect of a natural extract of Sclerocarya birrea on glucose metabolism in subjects with prediabetes. The duration of the study was 90 days. Thirty-three subjects assigned to the experimental group (daily ingestion of 100 mg of the nutraceutical product) and 34 assigned to the placebo group completed the study. There were 36 men and 31 women with a mean age of 32.3 ± 14.1 years. In the area under the curve (AUC) of the oral glucose tolerance test (OGTT), statistically significant decreases in the experimental group at 40 and 90 days as compared with baseline were found, whereas significant changes in the placebo group were not observed. Within-group differences were statistically significant in favor of the experimental group for glucose peak at OGTT, serum insulin, insulin resistance markers, and flow-mediated dilation. Changes in lipid and anthropometric parameters were not observed, although there was a trend for lower cholesterol levels and a decrease in body weight in the experimental group. Decreases in systolic blood pressure were also higher among subjects in the experimental group. This exploratory study confirms the antidiabetic activity of Sclerocarya birrea in prediabetes. Further studies using better measurements of beta-cell function are needed to clarify the underlying mechanisms of the hypoglycemic effect of this natural compound.Ciencias de la Alimentación2021info:eu-repo/semantics/articlehttp://hdl.handle.net/10952/8005reponame:RIUCAM. Repositorio Institucional de la Universidad Católica San Antonio de Murciainstname:Universidad Católica San Antonio de Murcia (UCAM)Inglés2015.08.ID+I.0072info:eu-repo/semantics/openAccessoai:repositorio.ucam.edu:10952/80052026-06-07T18:35:21Z |
| dc.title.none.fl_str_mv |
Effect of Dietary Supplementation with a Natural Extract of Sclerocarya birrea on Glycemic Metabolism in Subjects with Prediabetes: A Randomized Double-Blind Placebo-Controlled Study |
| title |
Effect of Dietary Supplementation with a Natural Extract of Sclerocarya birrea on Glycemic Metabolism in Subjects with Prediabetes: A Randomized Double-Blind Placebo-Controlled Study |
| spellingShingle |
Effect of Dietary Supplementation with a Natural Extract of Sclerocarya birrea on Glycemic Metabolism in Subjects with Prediabetes: A Randomized Double-Blind Placebo-Controlled Study Victoria Montesinos, Desirée Sclerocarya birrea Nutraceutical product Clinical trial Lipid profile Insulin resistance Glucose metabolism Prediabetes |
| title_short |
Effect of Dietary Supplementation with a Natural Extract of Sclerocarya birrea on Glycemic Metabolism in Subjects with Prediabetes: A Randomized Double-Blind Placebo-Controlled Study |
| title_full |
Effect of Dietary Supplementation with a Natural Extract of Sclerocarya birrea on Glycemic Metabolism in Subjects with Prediabetes: A Randomized Double-Blind Placebo-Controlled Study |
| title_fullStr |
Effect of Dietary Supplementation with a Natural Extract of Sclerocarya birrea on Glycemic Metabolism in Subjects with Prediabetes: A Randomized Double-Blind Placebo-Controlled Study |
| title_full_unstemmed |
Effect of Dietary Supplementation with a Natural Extract of Sclerocarya birrea on Glycemic Metabolism in Subjects with Prediabetes: A Randomized Double-Blind Placebo-Controlled Study |
| title_sort |
Effect of Dietary Supplementation with a Natural Extract of Sclerocarya birrea on Glycemic Metabolism in Subjects with Prediabetes: A Randomized Double-Blind Placebo-Controlled Study |
| dc.creator.none.fl_str_mv |
Victoria Montesinos, Desirée Sánchez Macarro, Maravillas Gabaldón, José Antonio Abellán Ruiz, María Salud Querol Calderón, María Luque Rubia, Antonio J. Bernal Morell, Enrique Ávila Gandía, Vicente López Román, Francisco Javier |
| author |
Victoria Montesinos, Desirée |
| author_facet |
Victoria Montesinos, Desirée Sánchez Macarro, Maravillas Gabaldón, José Antonio Abellán Ruiz, María Salud Querol Calderón, María Luque Rubia, Antonio J. Bernal Morell, Enrique Ávila Gandía, Vicente López Román, Francisco Javier |
| author_role |
author |
| author2 |
Sánchez Macarro, Maravillas Gabaldón, José Antonio Abellán Ruiz, María Salud Querol Calderón, María Luque Rubia, Antonio J. Bernal Morell, Enrique Ávila Gandía, Vicente López Román, Francisco Javier |
| author2_role |
author author author author author author author author |
| dc.subject.none.fl_str_mv |
Sclerocarya birrea Nutraceutical product Clinical trial Lipid profile Insulin resistance Glucose metabolism Prediabetes |
| topic |
Sclerocarya birrea Nutraceutical product Clinical trial Lipid profile Insulin resistance Glucose metabolism Prediabetes |
| description |
A randomized, double-blind, placebo-controlled study was conducted with the primary objective of assessing the effect of a natural extract of Sclerocarya birrea on glucose metabolism in subjects with prediabetes. The duration of the study was 90 days. Thirty-three subjects assigned to the experimental group (daily ingestion of 100 mg of the nutraceutical product) and 34 assigned to the placebo group completed the study. There were 36 men and 31 women with a mean age of 32.3 ± 14.1 years. In the area under the curve (AUC) of the oral glucose tolerance test (OGTT), statistically significant decreases in the experimental group at 40 and 90 days as compared with baseline were found, whereas significant changes in the placebo group were not observed. Within-group differences were statistically significant in favor of the experimental group for glucose peak at OGTT, serum insulin, insulin resistance markers, and flow-mediated dilation. Changes in lipid and anthropometric parameters were not observed, although there was a trend for lower cholesterol levels and a decrease in body weight in the experimental group. Decreases in systolic blood pressure were also higher among subjects in the experimental group. This exploratory study confirms the antidiabetic activity of Sclerocarya birrea in prediabetes. Further studies using better measurements of beta-cell function are needed to clarify the underlying mechanisms of the hypoglycemic effect of this natural compound. |
| publishDate |
2021 |
| dc.date.none.fl_str_mv |
2021 |
| dc.type.none.fl_str_mv |
info:eu-repo/semantics/article |
| format |
article |
| dc.identifier.none.fl_str_mv |
http://hdl.handle.net/10952/8005 |
| url |
http://hdl.handle.net/10952/8005 |
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Inglés |
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Inglés |
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2015.08.ID+I.0072 |
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info:eu-repo/semantics/openAccess |
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openAccess |
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reponame:RIUCAM. Repositorio Institucional de la Universidad Católica San Antonio de Murcia instname:Universidad Católica San Antonio de Murcia (UCAM) |
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Universidad Católica San Antonio de Murcia (UCAM) |
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RIUCAM. Repositorio Institucional de la Universidad Católica San Antonio de Murcia |
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RIUCAM. Repositorio Institucional de la Universidad Católica San Antonio de Murcia |
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15.811543 |