Dupilumab improves patient-reported outcomes in patients with chronic rhinosinusitis with nasal polyps and comorbid asthma

Chronic rhinosinusitis with nasal polyps (CRSwNP) is a common inflammatory condition affecting the upper airways, with chronic symptoms such as nasal congestion, partial (hyposmia) or total (anosmia) loss of smell, anterior/posterior rhinorrhea, and mild facial pain.1 As many as 66% of patients with...

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Bibliographic Details
Authors: Bachert, Claus, Hellings, Peter W., Mullol i Miret, Joaquim, Naclerio, Robert M., Chao, Jingdong, Amin, Nikhil, Grabher, Annette, Swanson, Brian N., Hamilton, Jennifer D., Guillonneau, Sophie, Christine Taniou, Zhang, Donghui, Pirozzi, Gianluca, Graham, Neil M. H., Staudinger, Heribert, Mannent, Leda P., Khan, Asif
Format: article
Status:Published version
Publication Date:2019
Country:España
Institution:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repository:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:2445/151860
Online Access:https://hdl.handle.net/2445/151860
Access Level:Open access
Keyword:Asma
Sinusitis
Asthma
Description
Summary:Chronic rhinosinusitis with nasal polyps (CRSwNP) is a common inflammatory condition affecting the upper airways, with chronic symptoms such as nasal congestion, partial (hyposmia) or total (anosmia) loss of smell, anterior/posterior rhinorrhea, and mild facial pain.1 As many as 66% of patients with CRSwNP have comorbid asthma and suffer from more severe nasal obstruction, higher levels of lower airway inflammation, and worse asthma control than those without CRS.2, 3 Thus, patients with CRSwNP and comorbid asthma have a high disease burden, seriously impacting health-related quality of life (HRQoL).2, 3 Markers of type 2-mediated inflammation and antibody production (eg, IL-5, IgE) are associated with both CRSwNP and asthma pathogenesis.2

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