Dupilumab improves patient-reported outcomes in patients with chronic rhinosinusitis with nasal polyps and comorbid asthma

Chronic rhinosinusitis with nasal polyps (CRSwNP) is a common inflammatory condition affecting the upper airways, with chronic symptoms such as nasal congestion, partial (hyposmia) or total (anosmia) loss of smell, anterior/posterior rhinorrhea, and mild facial pain.1 As many as 66% of patients with...

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Detalles Bibliográficos
Autores: Bachert, Claus, Hellings, Peter W., Mullol i Miret, Joaquim, Naclerio, Robert M., Chao, Jingdong, Amin, Nikhil, Grabher, Annette, Swanson, Brian N., Hamilton, Jennifer D., Guillonneau, Sophie, Christine Taniou, Zhang, Donghui, Pirozzi, Gianluca, Graham, Neil M. H., Staudinger, Heribert, Mannent, Leda P., Khan, Asif
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2019
País:España
Institución:Universidad de Barcelona
Repositorio:Dipòsit Digital de la UB
OAI Identifier:oai:diposit.ub.edu:2445/151860
Acceso en línea:https://hdl.handle.net/2445/151860
Access Level:acceso abierto
Palabra clave:Asma
Sinusitis
Asthma
Descripción
Sumario:Chronic rhinosinusitis with nasal polyps (CRSwNP) is a common inflammatory condition affecting the upper airways, with chronic symptoms such as nasal congestion, partial (hyposmia) or total (anosmia) loss of smell, anterior/posterior rhinorrhea, and mild facial pain.1 As many as 66% of patients with CRSwNP have comorbid asthma and suffer from more severe nasal obstruction, higher levels of lower airway inflammation, and worse asthma control than those without CRS.2, 3 Thus, patients with CRSwNP and comorbid asthma have a high disease burden, seriously impacting health-related quality of life (HRQoL).2, 3 Markers of type 2-mediated inflammation and antibody production (eg, IL-5, IgE) are associated with both CRSwNP and asthma pathogenesis.2

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