Emergence of progressive mutations in SARS-CoV-2 from a hematologic patient with prolonged viral replication

We documented a hematologic patient with prolonged SARS-CoV-2 viral replication in whom emergence of viral mutations was documented after the consecutive use of antivirals and convalescent plasma. The virus detected in the last of 12 clinical samples (day 237) had accumulated 22 changes in amino aci...

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Autores: Garcia Vidal, Carolina, Iglesias, María, Puerta-Alcalde, Pedro, Mas, Vicente, Cuesta Chasco, Genoveva, García Pouton, Nicole, Varona, Sarai, Pozo, Francisco, Vázquez Morón, Sonia, Marcos, Ma. Angeles, Soriano Viladomiu, Alex, Casas Flecha, Inmaculada, HEMATOCOVID19-Researchers Group
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2022
País:España
Institución:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositorio:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:2445/197930
Acceso en línea:https://hdl.handle.net/2445/197930
Access Level:acceso abierto
Palabra clave:COVID-19
SARS-CoV-2
Medicaments antivírics
Hematologia
Immunosupressió
Mutació (Biologia)
Antiviral agents
Hematology
Immunosuppression
Mutation (Biology)
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spelling Emergence of progressive mutations in SARS-CoV-2 from a hematologic patient with prolonged viral replicationGarcia Vidal, CarolinaIglesias, MaríaPuerta-Alcalde, PedroMas, VicenteCuesta Chasco, GenovevaGarcía Pouton, NicoleVarona, SaraiPozo, FranciscoVázquez Morón, SoniaMarcos, Ma. AngelesSoriano Viladomiu, AlexCasas Flecha, InmaculadaHEMATOCOVID19-Researchers GroupCOVID-19SARS-CoV-2Medicaments antivíricsHematologiaImmunosupressióMutació (Biologia)COVID-19SARS-CoV-2Antiviral agentsHematologyImmunosuppressionMutation (Biology)We documented a hematologic patient with prolonged SARS-CoV-2 viral replication in whom emergence of viral mutations was documented after the consecutive use of antivirals and convalescent plasma. The virus detected in the last of 12 clinical samples (day 237) had accumulated 22 changes in amino acids and 29 in nucleotides. Some of these changes, such as the E484Q, were mutations of concern as defined by WHO. This finding represents an enormous epidemiological threat and poses a major clinical challenge. Combined antiviral strategies, as well as specific strategies related to the diagnostic approach of prolonged infections for this specific population, may be needed.Frontiers Media2023202320222023info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion15 p.application/pdfhttps://hdl.handle.net/2445/197930Articles publicats en revistes (Fonaments Clínics)reponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésReproducció del document publicat a: https://doi.org/10.3389/fmicb.2022.826883Frontiers in Microbiology, 2022, vol. 13, p. 826883https://doi.org/10.3389/fmicb.2022.826883cc-by (c) Garcia Vidal, Carolina et al., 2022https://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:recercat.cat:2445/1979302026-05-29T05:05:01Z
dc.title.none.fl_str_mv Emergence of progressive mutations in SARS-CoV-2 from a hematologic patient with prolonged viral replication
title Emergence of progressive mutations in SARS-CoV-2 from a hematologic patient with prolonged viral replication
spellingShingle Emergence of progressive mutations in SARS-CoV-2 from a hematologic patient with prolonged viral replication
Garcia Vidal, Carolina
COVID-19
SARS-CoV-2
Medicaments antivírics
Hematologia
Immunosupressió
Mutació (Biologia)
COVID-19
SARS-CoV-2
Antiviral agents
Hematology
Immunosuppression
Mutation (Biology)
title_short Emergence of progressive mutations in SARS-CoV-2 from a hematologic patient with prolonged viral replication
title_full Emergence of progressive mutations in SARS-CoV-2 from a hematologic patient with prolonged viral replication
title_fullStr Emergence of progressive mutations in SARS-CoV-2 from a hematologic patient with prolonged viral replication
title_full_unstemmed Emergence of progressive mutations in SARS-CoV-2 from a hematologic patient with prolonged viral replication
title_sort Emergence of progressive mutations in SARS-CoV-2 from a hematologic patient with prolonged viral replication
dc.creator.none.fl_str_mv Garcia Vidal, Carolina
Iglesias, María
Puerta-Alcalde, Pedro
Mas, Vicente
Cuesta Chasco, Genoveva
García Pouton, Nicole
Varona, Sarai
Pozo, Francisco
Vázquez Morón, Sonia
Marcos, Ma. Angeles
Soriano Viladomiu, Alex
Casas Flecha, Inmaculada
HEMATOCOVID19-Researchers Group
author Garcia Vidal, Carolina
author_facet Garcia Vidal, Carolina
Iglesias, María
Puerta-Alcalde, Pedro
Mas, Vicente
Cuesta Chasco, Genoveva
García Pouton, Nicole
Varona, Sarai
Pozo, Francisco
Vázquez Morón, Sonia
Marcos, Ma. Angeles
Soriano Viladomiu, Alex
Casas Flecha, Inmaculada
HEMATOCOVID19-Researchers Group
author_role author
author2 Iglesias, María
Puerta-Alcalde, Pedro
Mas, Vicente
Cuesta Chasco, Genoveva
García Pouton, Nicole
Varona, Sarai
Pozo, Francisco
Vázquez Morón, Sonia
Marcos, Ma. Angeles
Soriano Viladomiu, Alex
Casas Flecha, Inmaculada
HEMATOCOVID19-Researchers Group
author2_role author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv COVID-19
SARS-CoV-2
Medicaments antivírics
Hematologia
Immunosupressió
Mutació (Biologia)
COVID-19
SARS-CoV-2
Antiviral agents
Hematology
Immunosuppression
Mutation (Biology)
topic COVID-19
SARS-CoV-2
Medicaments antivírics
Hematologia
Immunosupressió
Mutació (Biologia)
COVID-19
SARS-CoV-2
Antiviral agents
Hematology
Immunosuppression
Mutation (Biology)
description We documented a hematologic patient with prolonged SARS-CoV-2 viral replication in whom emergence of viral mutations was documented after the consecutive use of antivirals and convalescent plasma. The virus detected in the last of 12 clinical samples (day 237) had accumulated 22 changes in amino acids and 29 in nucleotides. Some of these changes, such as the E484Q, were mutations of concern as defined by WHO. This finding represents an enormous epidemiological threat and poses a major clinical challenge. Combined antiviral strategies, as well as specific strategies related to the diagnostic approach of prolonged infections for this specific population, may be needed.
publishDate 2022
dc.date.none.fl_str_mv 2022
2023
2023
2023
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/197930
url https://hdl.handle.net/2445/197930
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Reproducció del document publicat a: https://doi.org/10.3389/fmicb.2022.826883
Frontiers in Microbiology, 2022, vol. 13, p. 826883
https://doi.org/10.3389/fmicb.2022.826883
dc.rights.none.fl_str_mv cc-by (c) Garcia Vidal, Carolina et al., 2022
https://creativecommons.org/licenses/by/4.0/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv cc-by (c) Garcia Vidal, Carolina et al., 2022
https://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 15 p.
application/pdf
dc.publisher.none.fl_str_mv Frontiers Media
publisher.none.fl_str_mv Frontiers Media
dc.source.none.fl_str_mv Articles publicats en revistes (Fonaments Clínics)
reponame:Recercat. Dipósit de la Recerca de Catalunya
instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
instname_str Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
reponame_str Recercat. Dipósit de la Recerca de Catalunya
collection Recercat. Dipósit de la Recerca de Catalunya
repository.name.fl_str_mv
repository.mail.fl_str_mv
_version_ 1869419985570365440
score 15.811543

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