Emergence of progressive mutations in SARS-CoV-2 from a hematologic patient with prolonged viral replication

We documented a hematologic patient with prolonged SARS-CoV-2 viral replication in whom emergence of viral mutations was documented after the consecutive use of antivirals and convalescent plasma. The virus detected in the last of 12 clinical samples (day 237) had accumulated 22 changes in amino aci...

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Detalles Bibliográficos
Autores: Garcia Vidal, Carolina, Iglesias, María, Puerta-Alcalde, Pedro, Mas, Vicente, Cuesta Chasco, Genoveva, García Pouton, Nicole, Varona, Sarai, Pozo, Francisco, Vázquez Morón, Sonia, Marcos, Ma. Angeles, Soriano Viladomiu, Alex, Casas Flecha, Inmaculada, HEMATOCOVID19-Researchers Group
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2022
País:España
Institución:Universidad de Barcelona
Repositorio:Dipòsit Digital de la UB
OAI Identifier:oai:diposit.ub.edu:2445/197930
Acceso en línea:https://hdl.handle.net/2445/197930
Access Level:acceso abierto
Palabra clave:COVID-19
SARS-CoV-2
Medicaments antivírics
Hematologia
Immunosupressió
Mutació (Biologia)
Antiviral agents
Hematology
Immunosuppression
Mutation (Biology)
Descripción
Sumario:We documented a hematologic patient with prolonged SARS-CoV-2 viral replication in whom emergence of viral mutations was documented after the consecutive use of antivirals and convalescent plasma. The virus detected in the last of 12 clinical samples (day 237) had accumulated 22 changes in amino acids and 29 in nucleotides. Some of these changes, such as the E484Q, were mutations of concern as defined by WHO. This finding represents an enormous epidemiological threat and poses a major clinical challenge. Combined antiviral strategies, as well as specific strategies related to the diagnostic approach of prolonged infections for this specific population, may be needed.

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