Towards the Application of Purely Inorganic Icosahedral Boron Clusters in Emerging Nanomedicine

Traditionally, drugs were obtained by extraction from medicinal plants, but more recently also by organic synthesis. Today, medicinal chemistry continues to focus on organic compounds and the majority of commercially available drugs are organic molecules, which can incorporate nitrogen, oxygen, and...

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Detalles Bibliográficos
Autores: Teixidor, Francesc, Núñez Aguilera, Rosario, Viñas, Clara
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2023
País:España
Institución:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/336837
Acceso en línea:http://hdl.handle.net/10261/336837
https://api.elsevier.com/content/abstract/scopus_id/85161541331
Access Level:acceso abierto
Palabra clave:BNCT
COSAN
FESAN
PBFR
PET
SPECT
Antimicrobial
Bioimaging
Carboranes
Luminescence
Metallabis(dicarbollide)
Photodinamic therapy (PDT)
Proton therapy
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repository_id_str
spelling Towards the Application of Purely Inorganic Icosahedral Boron Clusters in Emerging NanomedicineTeixidor, FrancescNúñez Aguilera, RosarioViñas, ClaraBNCTCOSANFESANPBFRPETSPECTAntimicrobialBioimagingCarboranesLuminescenceMetallabis(dicarbollide)Photodinamic therapy (PDT)Proton therapyTraditionally, drugs were obtained by extraction from medicinal plants, but more recently also by organic synthesis. Today, medicinal chemistry continues to focus on organic compounds and the majority of commercially available drugs are organic molecules, which can incorporate nitrogen, oxygen, and halogens, as well as carbon and hydrogen. Aromatic organic compounds that play important roles in biochemistry find numerous applications ranging from drug delivery to nanotechnology or biomarkers. We achieved a major accomplishment by demonstrating experimentally/theoretically that boranes, carboranes, as well as metallabis(dicarbollides), exhibit global 3D aromaticity. Based on the stability-aromaticity relationship, as well as on the progress made in the synthesis of derivatized clusters, we have opened up new applications of boron icosahedral clusters as key components in the field of novel healthcare materials. In this brief review, we present the results obtained at the Laboratory of Inorganic Materials and Catalysis (LMI) of the Institut de Ciència de Materials de Barcelona (ICMAB-CSIC) with icosahedral boron clusters. These 3D geometric shape clusters, the semi-metallic nature of boron and the presence of exo-cluster hydrogen atoms that can interact with biomolecules through non-covalent hydrogen and dihydrogen bonds, play a key role in endowing these compounds with unique properties in largely unexplored (bio)materials.This work research was funded by the European Union’s Horizon 2020 grant number 768686, the Spanish Ministerio de Economía y Competitividad grant number PID2019-106832RB-I00 and, the Generalitat de Catalunya grant number 2017SGR1720.With funding from the Spanish government through the ‘Severo Ochoa Centre of Excellence’ accreditation (CEX2019-000917-S).Peer reviewedMultidisciplinary Digital Publishing InstituteEuropean CommissionMinisterio de Ciencia, Innovación y Universidades (España)Generalitat de CatalunyaAgencia Estatal de Investigación (España)Núñez Aguilera, [Rosario 0000-0003-4582-5148]Viñas, Clara [0000-0001-5000-0277]Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]202320232023info:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_6501Publisher's versioninfo:eu-repo/semantics/publishedVersionhttp://hdl.handle.net/10261/336837https://api.elsevier.com/content/abstract/scopus_id/85161541331reponame:DIGITAL.CSIC. Repositorio Institucional del CSICinstname:Consejo Superior de Investigaciones Científicas (CSIC)Inglés#PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE#info:eu-repo/grantAgreement/EC/H2020/768686info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/PID2019-106832RB-I00info:eu-repo/grantAgreement/AEI/Plan Estatal de investigación Científica y Técnica y de Innovación 2017-2020/CEX2019-000917-SMolecules (Basel, Switzerland)http://doi.org/10.3390/molecules28114449Síinfo:eu-repo/semantics/openAccessoai:digital.csic.es:10261/3368372026-05-22T06:33:51Z
dc.title.none.fl_str_mv Towards the Application of Purely Inorganic Icosahedral Boron Clusters in Emerging Nanomedicine
title Towards the Application of Purely Inorganic Icosahedral Boron Clusters in Emerging Nanomedicine
spellingShingle Towards the Application of Purely Inorganic Icosahedral Boron Clusters in Emerging Nanomedicine
Teixidor, Francesc
BNCT
COSAN
FESAN
PBFR
PET
SPECT
Antimicrobial
Bioimaging
Carboranes
Luminescence
Metallabis(dicarbollide)
Photodinamic therapy (PDT)
Proton therapy
title_short Towards the Application of Purely Inorganic Icosahedral Boron Clusters in Emerging Nanomedicine
title_full Towards the Application of Purely Inorganic Icosahedral Boron Clusters in Emerging Nanomedicine
title_fullStr Towards the Application of Purely Inorganic Icosahedral Boron Clusters in Emerging Nanomedicine
title_full_unstemmed Towards the Application of Purely Inorganic Icosahedral Boron Clusters in Emerging Nanomedicine
title_sort Towards the Application of Purely Inorganic Icosahedral Boron Clusters in Emerging Nanomedicine
dc.creator.none.fl_str_mv Teixidor, Francesc
Núñez Aguilera, Rosario
Viñas, Clara
author Teixidor, Francesc
author_facet Teixidor, Francesc
Núñez Aguilera, Rosario
Viñas, Clara
author_role author
author2 Núñez Aguilera, Rosario
Viñas, Clara
author2_role author
author
dc.contributor.none.fl_str_mv European Commission
Ministerio de Ciencia, Innovación y Universidades (España)
Generalitat de Catalunya
Agencia Estatal de Investigación (España)
Núñez Aguilera, [Rosario 0000-0003-4582-5148]
Viñas, Clara [0000-0001-5000-0277]
Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]
dc.subject.none.fl_str_mv BNCT
COSAN
FESAN
PBFR
PET
SPECT
Antimicrobial
Bioimaging
Carboranes
Luminescence
Metallabis(dicarbollide)
Photodinamic therapy (PDT)
Proton therapy
topic BNCT
COSAN
FESAN
PBFR
PET
SPECT
Antimicrobial
Bioimaging
Carboranes
Luminescence
Metallabis(dicarbollide)
Photodinamic therapy (PDT)
Proton therapy
description Traditionally, drugs were obtained by extraction from medicinal plants, but more recently also by organic synthesis. Today, medicinal chemistry continues to focus on organic compounds and the majority of commercially available drugs are organic molecules, which can incorporate nitrogen, oxygen, and halogens, as well as carbon and hydrogen. Aromatic organic compounds that play important roles in biochemistry find numerous applications ranging from drug delivery to nanotechnology or biomarkers. We achieved a major accomplishment by demonstrating experimentally/theoretically that boranes, carboranes, as well as metallabis(dicarbollides), exhibit global 3D aromaticity. Based on the stability-aromaticity relationship, as well as on the progress made in the synthesis of derivatized clusters, we have opened up new applications of boron icosahedral clusters as key components in the field of novel healthcare materials. In this brief review, we present the results obtained at the Laboratory of Inorganic Materials and Catalysis (LMI) of the Institut de Ciència de Materials de Barcelona (ICMAB-CSIC) with icosahedral boron clusters. These 3D geometric shape clusters, the semi-metallic nature of boron and the presence of exo-cluster hydrogen atoms that can interact with biomolecules through non-covalent hydrogen and dihydrogen bonds, play a key role in endowing these compounds with unique properties in largely unexplored (bio)materials.
publishDate 2023
dc.date.none.fl_str_mv 2023
2023
2023
dc.type.none.fl_str_mv info:eu-repo/semantics/article
http://purl.org/coar/resource_type/c_6501
Publisher's version
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10261/336837
https://api.elsevier.com/content/abstract/scopus_id/85161541331
url http://hdl.handle.net/10261/336837
https://api.elsevier.com/content/abstract/scopus_id/85161541331
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv #PLACEHOLDER_PARENT_METADATA_VALUE#
#PLACEHOLDER_PARENT_METADATA_VALUE#
#PLACEHOLDER_PARENT_METADATA_VALUE#
info:eu-repo/grantAgreement/EC/H2020/768686
info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/PID2019-106832RB-I00
info:eu-repo/grantAgreement/AEI/Plan Estatal de investigación Científica y Técnica y de Innovación 2017-2020/CEX2019-000917-S
Molecules (Basel, Switzerland)
http://doi.org/10.3390/molecules28114449
Sí
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Multidisciplinary Digital Publishing Institute
publisher.none.fl_str_mv Multidisciplinary Digital Publishing Institute
dc.source.none.fl_str_mv reponame:DIGITAL.CSIC. Repositorio Institucional del CSIC
instname:Consejo Superior de Investigaciones Científicas (CSIC)
instname_str Consejo Superior de Investigaciones Científicas (CSIC)
reponame_str DIGITAL.CSIC. Repositorio Institucional del CSIC
collection DIGITAL.CSIC. Repositorio Institucional del CSIC
repository.name.fl_str_mv
repository.mail.fl_str_mv
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