Purging behavior modulates the relationships of hormonal and behavioral parameters in women with eating disorders

Background/Aims: There is ample consensus that there is a neurophysiological basis for eating disorders (ED). Traits of personality translate into behavioral traits, purging being a well-defined transversal example. The direct implication of steroid hormones on ED has seldom been studied, despite th...

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Detalles Bibliográficos
Autores: Grasa Martínez, Maria del Mar|||0000-0001-6362-0504, Villarreal, Laura|||0000-0002-4040-3280, Granero, Roser|||0000-0001-6308-3198, Vilà, Ruth|||0000-0003-3768-1105, Penelo Werner, Eva|||0000-0001-6796-7660, Agüera, Zaida|||0000-0003-4453-4939, Jiménez Murcia, Susana|||0000-0002-3596-8033, Romero, María del Mar|||0000-0001-6274-5743, Menchón Magriñá, José Manuel|||0000-0002-6231-6524, Remesar, Xavier|||0000-0002-9707-7287, Fernández Aranda, Fernando|||0000-0002-2968-9898, Alemany, Marià|||0000-0002-9783-8293
Tipo de recurso: artículo
Fecha de publicación:2013
País:España
Institución:Universitat Autònoma de Barcelona
Repositorio:Dipòsit Digital de Documents de la UAB
Idioma:inglés
OAI Identifier:oai:ddd.uab.cat:319651
Acceso en línea:https://ddd.uab.cat/record/319651
https://dx.doi.org/urn:doi:10.1159/000350473
Access Level:acceso abierto
Palabra clave:Androgens
Anorexia
Bulimia
Corticosteroid-binding globulin
Eating disorders
Estrogens
Glucocorticoids
Sex hormone-binding globulin
Descripción
Sumario:Background/Aims: There is ample consensus that there is a neurophysiological basis for eating disorders (ED). Traits of personality translate into behavioral traits, purging being a well-defined transversal example. The direct implication of steroid hormones on ED has seldom been studied, despite their effects on behavior. Methods: After psychological in- terview analysis, 57 ED female patients (31 purgative and 26 nonpurgative) and 17 female controls were studied. Met- abolic parameters and analysis of androgen, estrogen and glucocorticoid hormones were determined in parallel to the psychopathological profile (EDI2 and SCL-90-R) and anth- ropometric measurements. Results: Psychometric tests showed clear differences between ED and controls, but there were few hormonal-metabolic significant differences. In purgative ED there were repeated (significant) positive correla- tions with corticosteroid-binding globulin (CBG) and nega- tive correlations with sex hormone-binding globulin (SHBG) versus eating and general psychopathology. In nonpurging ED there were positive correlations for deoxycortisol, free fat- ty acids and albumin and negative for aspartate aminotrans- ferase and psychopathological traits. Conclusion: The data suggest that CBG/corticosteroids and sexual hormones/ SHBG are involved in purging behavior and its psychopathol- ogy and severity scores. Correlations of selected psychomet- ric data and the CBG/SHBG levels in purging may eventually result in clinical markers. This approach may provide addi- tional clues for understanding the pathogenesis of ED.

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