Relationship between adiponectin, TNFa, and SHBG in prepubertal children with obesity
BackgroundSex hormone-binding globulin (SHBG) levels are low in adult subjects with obesity when compared to normal-weight individuals. Obesity is associated with higher tumor necrosis factor alpha (TNF alpha) plasma levels and lower adiponectin levels. Moreover, we have recently elucidated the mole...
| Autores: | , , , , , |
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| Formato: | artículo |
| Estado: | Versión publicada |
| Fecha de publicación: | 2021 |
| País: | España |
| Recursos: | Fundació Sant Joan de Déu |
| Repositorio: | r-FSJD. Repositorio Institucional de Producción Científica de la Fundació Sant Joan de Déu |
| OAI Identifier: | oai:fsjd.fundanetsuite.com:p19260 |
| Acesso em linha: | https://fsjd.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=19260 |
| Access Level: | acceso abierto |
| Palavra-chave: | Prepubertal children Obesity Sex hormone-binding globulin Cytokines |
| Resumo: | BackgroundSex hormone-binding globulin (SHBG) levels are low in adult subjects with obesity when compared to normal-weight individuals. Obesity is associated with higher tumor necrosis factor alpha (TNF alpha) plasma levels and lower adiponectin levels. Moreover, we have recently elucidated the molecular mechanisms by which TNF alpha and adiponectin regulate hepatic SHBG production.AimThe main objective of this study was to assess if the adult associations between TNF alpha, adiponectin, and SHBG are present in prepubertal children.MethodsWe determined several morphometric and biochemical parameters in normal-weight (n=15) and obese prepubertal (n=51) children, as well as quantified plasma SHBG, TNF alpha receptor 1 (TNF alpha-R1), and adiponectin levels.ResultsOur results showed that prepubertal children with obesity had decreased plasma SHBG levels compared to normal-weight controls (67 nmol/L vs 172 nmol/L). Importantly, SHBG plasma levels correlated significantly (P < 0.05) with TNF alpha (negatively, ssstd= - 0.31) and adiponectin (positively, ssstd= 0.58) suggesting an important role of these two cytokines in determining plasma SHBG levels in prepubertal children.ConclusionsOur results suggest that plasma adiponectin levels may play a more important role than TNF alpha in influencing plasma SHBG levels in our prepubertal population with obesity. |
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