Airway Complications after Lung Transplantation—A Contemporary Series of 400 Bronchial Anastomoses from a Single Center

(1)Objective: To determine whether recent advances in lung transplantation (LT) have reduced the incidence and changed the risk factors for airway complications (AC). (2) Methods: Retrospective analysis of patients receiving a lung transplant between January 2007 and January 2019. An AC was defined...

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Autores: Muñoz Fos, Anna, Moreno, Paula, González, Francisco Javier, Ruiz, Eloisa, Vaquero, Jose Manuel, Baamonde, Carlos, Cerezo, Francisco, Algar, Javier, Ramos Izquierdo, Ricard, Salvatierra, Ángel, Alvarez, Antonio
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2023
País:España
Institución:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositorio:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:2445/200920
Acceso en línea:https://hdl.handle.net/2445/200920
Access Level:acceso abierto
Palabra clave:Trasplantament d'òrgans
Pulmó
Complicacions quirúrgiques
Transplantation of organs
Lung
Complications of surgery
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spelling Airway Complications after Lung Transplantation—A Contemporary Series of 400 Bronchial Anastomoses from a Single CenterMuñoz Fos, AnnaMoreno, PaulaGonzález, Francisco JavierRuiz, EloisaVaquero, Jose ManuelBaamonde, CarlosCerezo, FranciscoAlgar, JavierRamos Izquierdo, RicardSalvatierra, ÁngelAlvarez, AntonioTrasplantament d'òrgansPulmóComplicacions quirúrgiquesTransplantation of organsLungComplications of surgery(1)Objective: To determine whether recent advances in lung transplantation (LT) have reduced the incidence and changed the risk factors for airway complications (AC). (2) Methods: Retrospective analysis of patients receiving a lung transplant between January 2007 and January 2019. An AC was defined as a bronchoscopic abnormality in the airway, either requiring or not requiring an endoscopic or surgical intervention. Both univariable and multivariable analyses were performed to identify risk factors for AC. (3) Results: 285 lung transplants (170 single and 115 bilateral lung transplants) were analysed, comprising 400 anastomoses at risk. A total of 50 anastomoses resulted in AC (12%). There were 14 anastomotic and 11 non-anastomotic stenoses, 4 dehiscences, and 3 malacias. Independent predictors for AC were: gender male (OR: 4.18; p = 0.002), cardiac comorbidities (OR: 2.74; p = 0.009), prolonged postoperative mechanical ventilation (OR: 2.5; p = 0.02), PaO2/FiO2 < 300 mmHg at 24 h post-LT (OR: 2.48; p = 0.01), graft infection (OR: 2.16; p = 0.05), and post-LT isolation of Aspergillus spp. (OR: 2.63; p = 0.03). (4) Conclusions: In spite of advances in lung transplantation practice, the risk factors, incidence, and lethality of AC after LT remains unchanged. Graft dysfunction, an infected environment, and the need of prolonged mechanical ventilation remain an Achilles heel for AC.MDPI AG2023202320232023info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion10 p.application/pdfhttps://hdl.handle.net/2445/200920Articles publicats en revistes (Patologia i Terapèutica Experimental)reponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésReproducció del document publicat a: https://doi.org/10.3390/jcm12093061Journal of Clinical Medicine, 2023, vol. 12, num. 9, p. 3061https://doi.org/10.3390/jcm12093061cc by (c) Muñoz Fos, Anna et al., 2023http://creativecommons.org/licenses/by/3.0/es/info:eu-repo/semantics/openAccessoai:recercat.cat:2445/2009202026-05-29T05:05:01Z
dc.title.none.fl_str_mv Airway Complications after Lung Transplantation—A Contemporary Series of 400 Bronchial Anastomoses from a Single Center
title Airway Complications after Lung Transplantation—A Contemporary Series of 400 Bronchial Anastomoses from a Single Center
spellingShingle Airway Complications after Lung Transplantation—A Contemporary Series of 400 Bronchial Anastomoses from a Single Center
Muñoz Fos, Anna
Trasplantament d'òrgans
Pulmó
Complicacions quirúrgiques
Transplantation of organs
Lung
Complications of surgery
title_short Airway Complications after Lung Transplantation—A Contemporary Series of 400 Bronchial Anastomoses from a Single Center
title_full Airway Complications after Lung Transplantation—A Contemporary Series of 400 Bronchial Anastomoses from a Single Center
title_fullStr Airway Complications after Lung Transplantation—A Contemporary Series of 400 Bronchial Anastomoses from a Single Center
title_full_unstemmed Airway Complications after Lung Transplantation—A Contemporary Series of 400 Bronchial Anastomoses from a Single Center
title_sort Airway Complications after Lung Transplantation—A Contemporary Series of 400 Bronchial Anastomoses from a Single Center
dc.creator.none.fl_str_mv Muñoz Fos, Anna
Moreno, Paula
González, Francisco Javier
Ruiz, Eloisa
Vaquero, Jose Manuel
Baamonde, Carlos
Cerezo, Francisco
Algar, Javier
Ramos Izquierdo, Ricard
Salvatierra, Ángel
Alvarez, Antonio
author Muñoz Fos, Anna
author_facet Muñoz Fos, Anna
Moreno, Paula
González, Francisco Javier
Ruiz, Eloisa
Vaquero, Jose Manuel
Baamonde, Carlos
Cerezo, Francisco
Algar, Javier
Ramos Izquierdo, Ricard
Salvatierra, Ángel
Alvarez, Antonio
author_role author
author2 Moreno, Paula
González, Francisco Javier
Ruiz, Eloisa
Vaquero, Jose Manuel
Baamonde, Carlos
Cerezo, Francisco
Algar, Javier
Ramos Izquierdo, Ricard
Salvatierra, Ángel
Alvarez, Antonio
author2_role author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Trasplantament d'òrgans
Pulmó
Complicacions quirúrgiques
Transplantation of organs
Lung
Complications of surgery
topic Trasplantament d'òrgans
Pulmó
Complicacions quirúrgiques
Transplantation of organs
Lung
Complications of surgery
description (1)Objective: To determine whether recent advances in lung transplantation (LT) have reduced the incidence and changed the risk factors for airway complications (AC). (2) Methods: Retrospective analysis of patients receiving a lung transplant between January 2007 and January 2019. An AC was defined as a bronchoscopic abnormality in the airway, either requiring or not requiring an endoscopic or surgical intervention. Both univariable and multivariable analyses were performed to identify risk factors for AC. (3) Results: 285 lung transplants (170 single and 115 bilateral lung transplants) were analysed, comprising 400 anastomoses at risk. A total of 50 anastomoses resulted in AC (12%). There were 14 anastomotic and 11 non-anastomotic stenoses, 4 dehiscences, and 3 malacias. Independent predictors for AC were: gender male (OR: 4.18; p = 0.002), cardiac comorbidities (OR: 2.74; p = 0.009), prolonged postoperative mechanical ventilation (OR: 2.5; p = 0.02), PaO2/FiO2 < 300 mmHg at 24 h post-LT (OR: 2.48; p = 0.01), graft infection (OR: 2.16; p = 0.05), and post-LT isolation of Aspergillus spp. (OR: 2.63; p = 0.03). (4) Conclusions: In spite of advances in lung transplantation practice, the risk factors, incidence, and lethality of AC after LT remains unchanged. Graft dysfunction, an infected environment, and the need of prolonged mechanical ventilation remain an Achilles heel for AC.
publishDate 2023
dc.date.none.fl_str_mv 2023
2023
2023
2023
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/200920
url https://hdl.handle.net/2445/200920
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Reproducció del document publicat a: https://doi.org/10.3390/jcm12093061
Journal of Clinical Medicine, 2023, vol. 12, num. 9, p. 3061
https://doi.org/10.3390/jcm12093061
dc.rights.none.fl_str_mv cc by (c) Muñoz Fos, Anna et al., 2023
http://creativecommons.org/licenses/by/3.0/es/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv cc by (c) Muñoz Fos, Anna et al., 2023
http://creativecommons.org/licenses/by/3.0/es/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 10 p.
application/pdf
dc.publisher.none.fl_str_mv MDPI AG
publisher.none.fl_str_mv MDPI AG
dc.source.none.fl_str_mv Articles publicats en revistes (Patologia i Terapèutica Experimental)
reponame:Recercat. Dipósit de la Recerca de Catalunya
instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
instname_str Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
reponame_str Recercat. Dipósit de la Recerca de Catalunya
collection Recercat. Dipósit de la Recerca de Catalunya
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,812429

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