Role and predictive value of red blood cells in breast cancer metastasis

Breast cancer is the most common cancer diagnosed in women around the world. Around 30% of the patients will eventually develop metastasis, which is responsible for 90 % of cancerrelated deaths. In order to find new biomarkers and therapy targets for these patients, it is important to study the meta...

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Detalhes bibliográficos
Autor: Yáñez Gómez, Celso
Formato: tesis doctoral
Fecha de publicación:2024
País:España
Recursos:Universidad de Santiago de Compostela (USC)
Repositorio:Minerva. Repositorio Institucional de la Universidad de Santiago de Compostela
Idioma:inglés
OAI Identifier:oai:minerva.usc.gal:10347/37670
Acesso em linha:https://hdl.handle.net/10347/37670
Access Level:acceso abierto
Palavra-chave:Breast Cancer (BC)
metastasis
bloodstream
liquid biopsy
red blood cells
320101 Oncología
240701 Cultivo celular
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spelling Role and predictive value of red blood cells in breast cancer metastasisYáñez Gómez, CelsoBreast Cancer (BC)metastasisbloodstreamliquid biopsyred blood cells320101 Oncología240701 Cultivo celularBreast cancer is the most common cancer diagnosed in women around the world. Around 30% of the patients will eventually develop metastasis, which is responsible for 90 % of cancerrelated deaths. In order to find new biomarkers and therapy targets for these patients, it is important to study the metastatic process and the cells that take part in it. This thesis focused on the study of red blood cells, one of the most overlooked interplayer in cancer and metastasis. The results shown that RBCs from metastatic breast cancer patients were capable of interacting, and more importantly, modifying breast cancer cells, increasing their aggressiveness. Moreover, this thesis provided evidence of the RBCs potential to be used as predictive biomarkers of the presence of metastasis.Costa Nogueira, ClotildeLópez López, RafaelUniversidade de Santiago de Compostela. Escola de Doutoramento Internacional (EDIUS)20242024-01-0120242024-01-01doctoral thesishttp://purl.org/coar/resource_type/c_db06info:eu-repo/semantics/doctoralThesisapplication/pdfhttps://hdl.handle.net/10347/37670reponame:Minerva. Repositorio Institucional de la Universidad de Santiago de Compostelainstname:Universidad de Santiago de Compostela (USC)Inglésengopen accesshttp://purl.org/coar/access_right/c_abf2Attribution-NonCommercial-NoDerivatives 4.0 Internationalhttp://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/openAccessoai:minerva.usc.gal:10347/376702026-06-15T12:47:27Z
dc.title.none.fl_str_mv Role and predictive value of red blood cells in breast cancer metastasis
title Role and predictive value of red blood cells in breast cancer metastasis
spellingShingle Role and predictive value of red blood cells in breast cancer metastasis
Yáñez Gómez, Celso
Breast Cancer (BC)
metastasis
bloodstream
liquid biopsy
red blood cells
320101 Oncología
240701 Cultivo celular
title_short Role and predictive value of red blood cells in breast cancer metastasis
title_full Role and predictive value of red blood cells in breast cancer metastasis
title_fullStr Role and predictive value of red blood cells in breast cancer metastasis
title_full_unstemmed Role and predictive value of red blood cells in breast cancer metastasis
title_sort Role and predictive value of red blood cells in breast cancer metastasis
dc.creator.none.fl_str_mv Yáñez Gómez, Celso
author Yáñez Gómez, Celso
author_facet Yáñez Gómez, Celso
author_role author
dc.contributor.none.fl_str_mv Costa Nogueira, Clotilde
López López, Rafael
Universidade de Santiago de Compostela. Escola de Doutoramento Internacional (EDIUS)
dc.subject.none.fl_str_mv Breast Cancer (BC)
metastasis
bloodstream
liquid biopsy
red blood cells
320101 Oncología
240701 Cultivo celular
topic Breast Cancer (BC)
metastasis
bloodstream
liquid biopsy
red blood cells
320101 Oncología
240701 Cultivo celular
description Breast cancer is the most common cancer diagnosed in women around the world. Around 30% of the patients will eventually develop metastasis, which is responsible for 90 % of cancerrelated deaths. In order to find new biomarkers and therapy targets for these patients, it is important to study the metastatic process and the cells that take part in it. This thesis focused on the study of red blood cells, one of the most overlooked interplayer in cancer and metastasis. The results shown that RBCs from metastatic breast cancer patients were capable of interacting, and more importantly, modifying breast cancer cells, increasing their aggressiveness. Moreover, this thesis provided evidence of the RBCs potential to be used as predictive biomarkers of the presence of metastasis.
publishDate 2024
dc.date.none.fl_str_mv 2024
2024-01-01
2024
2024-01-01
dc.type.none.fl_str_mv doctoral thesis
http://purl.org/coar/resource_type/c_db06
dc.type.openaire.fl_str_mv info:eu-repo/semantics/doctoralThesis
format doctoralThesis
dc.identifier.none.fl_str_mv https://hdl.handle.net/10347/37670
url https://hdl.handle.net/10347/37670
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution-NonCommercial-NoDerivatives 4.0 International
http://creativecommons.org/licenses/by-nc-nd/4.0/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution-NonCommercial-NoDerivatives 4.0 International
http://creativecommons.org/licenses/by-nc-nd/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:Minerva. Repositorio Institucional de la Universidad de Santiago de Compostela
instname:Universidad de Santiago de Compostela (USC)
instname_str Universidad de Santiago de Compostela (USC)
reponame_str Minerva. Repositorio Institucional de la Universidad de Santiago de Compostela
collection Minerva. Repositorio Institucional de la Universidad de Santiago de Compostela
repository.name.fl_str_mv
repository.mail.fl_str_mv
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