Role and predictive value of red blood cells in breast cancer metastasis
Breast cancer is the most common cancer diagnosed in women around the world. Around 30% of the patients will eventually develop metastasis, which is responsible for 90 % of cancerrelated deaths. In order to find new biomarkers and therapy targets for these patients, it is important to study the meta...
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| Tipo de recurso: | tesis doctoral |
| Fecha de publicación: | 2024 |
| País: | España |
| Institución: | Universidad de Santiago de Compostela (USC) |
| Repositorio: | Minerva. Repositorio Institucional de la Universidad de Santiago de Compostela |
| Idioma: | inglés |
| OAI Identifier: | oai:minerva.usc.gal:10347/37670 |
| Acceso en línea: | https://hdl.handle.net/10347/37670 |
| Access Level: | acceso abierto |
| Palabra clave: | Breast Cancer (BC) metastasis bloodstream liquid biopsy red blood cells 320101 Oncología 240701 Cultivo celular |
| Sumario: | Breast cancer is the most common cancer diagnosed in women around the world. Around 30% of the patients will eventually develop metastasis, which is responsible for 90 % of cancerrelated deaths. In order to find new biomarkers and therapy targets for these patients, it is important to study the metastatic process and the cells that take part in it. This thesis focused on the study of red blood cells, one of the most overlooked interplayer in cancer and metastasis. The results shown that RBCs from metastatic breast cancer patients were capable of interacting, and more importantly, modifying breast cancer cells, increasing their aggressiveness. Moreover, this thesis provided evidence of the RBCs potential to be used as predictive biomarkers of the presence of metastasis. |
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