Skin microdialysis
Skin microdialysis (SMD) is a versatile sampling technique that can be used to recover soluble endogenous and exogenous molecules from the extracellular compartment of human skin. Due to its minimally invasive character, SMD can be applied in both clinical and preclinical settings. Despite being ava...
| Autores: | , , , , , , , , , , , |
|---|---|
| Tipo de recurso: | artículo |
| Fecha de publicación: | 2019 |
| País: | España |
| Institución: | Universitat Autònoma de Barcelona |
| Repositorio: | Dipòsit Digital de Documents de la UAB |
| Idioma: | inglés |
| OAI Identifier: | oai:ddd.uab.cat:226430 |
| Acceso en línea: | https://ddd.uab.cat/record/226430 https://dx.doi.org/urn:doi:10.1186/s13601-019-0262-y |
| Access Level: | acceso abierto |
| Palabra clave: | Microdialysis Cutaneous Inflammation Interstitial Dermal |
| id |
ES_cd8de5019fbd79e68d6920cbff85eb33 |
|---|---|
| oai_identifier_str |
oai:ddd.uab.cat:226430 |
| network_acronym_str |
ES |
| network_name_str |
España |
| repository_id_str |
|
| spelling |
Skin microdialysismethods, applications and future opportunities-an EAACI position paperBaumann, Katrine Y.Church, Martin K.Clough, Geraldine F.Quist, Sven RoySchmelz, MartinSkov, Per Stahl|||0000-0002-2481-4549Anderson, Chris D.Tannert, Line KringGiménez-Arnau, Ana M|||0000-0001-5434-7753Frischbutter, StefanScheffel, JörgMaurer, Marcus|||0000-0002-4121-481XMicrodialysisCutaneousInflammationInterstitialDermalSkin microdialysis (SMD) is a versatile sampling technique that can be used to recover soluble endogenous and exogenous molecules from the extracellular compartment of human skin. Due to its minimally invasive character, SMD can be applied in both clinical and preclinical settings. Despite being available since the 1990s, the technique has still not reached its full potential use as a tool to explore pathophysiological mechanisms of allergic and inflammatory reactions in the skin. Therefore, an EAACI Task Force on SMD was formed to disseminate knowledge about the technique and its many applications. This position paper from the task force provides an overview of the current use of SMD in the investigation of the pathogenesis of chronic inflammatory skin diseases, such as atopic dermatitis, chronic urticaria, psoriasis, and in studies of cutaneous events during type 1 hypersensitivity reactions. Furthermore, this paper covers drug hypersensitivity, UVB-induced- and neurogenic inflammation, and drug penetration investigated by SMD. The aim of this paper is to encourage the use of SMD and to make the technique easily accessible by providing an overview of methodology and applications, supported by standardized operating procedures for SMD in vivo and ex vivo. 22019-01-0120192019-01-01Article de revisióhttp://purl.org/coar/resource_type/c_dcae04bcVoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfhttps://ddd.uab.cat/record/226430https://dx.doi.org/urn:doi:10.1186/s13601-019-0262-yreponame:Dipòsit Digital de Documents de la UABinstname:Universitat Autònoma de BarcelonaInglésengopen accesshttp://purl.org/coar/access_right/c_abf2Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.https://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:ddd.uab.cat:2264302026-06-06T12:50:31Z |
| dc.title.none.fl_str_mv |
Skin microdialysis methods, applications and future opportunities-an EAACI position paper |
| title |
Skin microdialysis |
| spellingShingle |
Skin microdialysis Baumann, Katrine Y. Microdialysis Cutaneous Inflammation Interstitial Dermal |
| title_short |
Skin microdialysis |
| title_full |
Skin microdialysis |
| title_fullStr |
Skin microdialysis |
| title_full_unstemmed |
Skin microdialysis |
| title_sort |
Skin microdialysis |
| dc.creator.none.fl_str_mv |
Baumann, Katrine Y. Church, Martin K. Clough, Geraldine F. Quist, Sven Roy Schmelz, Martin Skov, Per Stahl|||0000-0002-2481-4549 Anderson, Chris D. Tannert, Line Kring Giménez-Arnau, Ana M|||0000-0001-5434-7753 Frischbutter, Stefan Scheffel, Jörg Maurer, Marcus|||0000-0002-4121-481X |
| author |
Baumann, Katrine Y. |
| author_facet |
Baumann, Katrine Y. Church, Martin K. Clough, Geraldine F. Quist, Sven Roy Schmelz, Martin Skov, Per Stahl|||0000-0002-2481-4549 Anderson, Chris D. Tannert, Line Kring Giménez-Arnau, Ana M|||0000-0001-5434-7753 Frischbutter, Stefan Scheffel, Jörg Maurer, Marcus|||0000-0002-4121-481X |
| author_role |
author |
| author2 |
Church, Martin K. Clough, Geraldine F. Quist, Sven Roy Schmelz, Martin Skov, Per Stahl|||0000-0002-2481-4549 Anderson, Chris D. Tannert, Line Kring Giménez-Arnau, Ana M|||0000-0001-5434-7753 Frischbutter, Stefan Scheffel, Jörg Maurer, Marcus|||0000-0002-4121-481X |
| author2_role |
author author author author author author author author author author author |
| dc.subject.none.fl_str_mv |
Microdialysis Cutaneous Inflammation Interstitial Dermal |
| topic |
Microdialysis Cutaneous Inflammation Interstitial Dermal |
| description |
Skin microdialysis (SMD) is a versatile sampling technique that can be used to recover soluble endogenous and exogenous molecules from the extracellular compartment of human skin. Due to its minimally invasive character, SMD can be applied in both clinical and preclinical settings. Despite being available since the 1990s, the technique has still not reached its full potential use as a tool to explore pathophysiological mechanisms of allergic and inflammatory reactions in the skin. Therefore, an EAACI Task Force on SMD was formed to disseminate knowledge about the technique and its many applications. This position paper from the task force provides an overview of the current use of SMD in the investigation of the pathogenesis of chronic inflammatory skin diseases, such as atopic dermatitis, chronic urticaria, psoriasis, and in studies of cutaneous events during type 1 hypersensitivity reactions. Furthermore, this paper covers drug hypersensitivity, UVB-induced- and neurogenic inflammation, and drug penetration investigated by SMD. The aim of this paper is to encourage the use of SMD and to make the technique easily accessible by providing an overview of methodology and applications, supported by standardized operating procedures for SMD in vivo and ex vivo. |
| publishDate |
2019 |
| dc.date.none.fl_str_mv |
2 2019-01-01 2019 2019-01-01 |
| dc.type.none.fl_str_mv |
Article de revisió http://purl.org/coar/resource_type/c_dcae04bc VoR http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| dc.type.openaire.fl_str_mv |
info:eu-repo/semantics/article |
| format |
article |
| dc.identifier.none.fl_str_mv |
https://ddd.uab.cat/record/226430 https://dx.doi.org/urn:doi:10.1186/s13601-019-0262-y |
| url |
https://ddd.uab.cat/record/226430 https://dx.doi.org/urn:doi:10.1186/s13601-019-0262-y |
| dc.language.none.fl_str_mv |
Inglés eng |
| language_invalid_str_mv |
Inglés |
| language |
eng |
| dc.rights.none.fl_str_mv |
open access http://purl.org/coar/access_right/c_abf2 https://creativecommons.org/licenses/by/4.0/ |
| dc.rights.openaire.fl_str_mv |
info:eu-repo/semantics/openAccess |
| rights_invalid_str_mv |
open access http://purl.org/coar/access_right/c_abf2 https://creativecommons.org/licenses/by/4.0/ |
| eu_rights_str_mv |
openAccess |
| dc.format.none.fl_str_mv |
application/pdf |
| dc.source.none.fl_str_mv |
reponame:Dipòsit Digital de Documents de la UAB instname:Universitat Autònoma de Barcelona |
| instname_str |
Universitat Autònoma de Barcelona |
| reponame_str |
Dipòsit Digital de Documents de la UAB |
| collection |
Dipòsit Digital de Documents de la UAB |
| repository.name.fl_str_mv |
|
| repository.mail.fl_str_mv |
|
| _version_ |
1869419865102614528 |
| score |
15,812429 |