Drosophila dorsal closure: An orchestra of forces to zip shut the embryo

Dorsal closure, a late-embryogenesis process, consists in the sealing of an epidermal gap on the dorsal side of the Drosophila embryo. Because of its similarities with wound healing and neural tube closure in humans, it has been extensively studied in the last twenty years. The process requires the...

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Detalles Bibliográficos
Autores: Hayes, D. Peran, 1983-, Solon, Jérôme
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2017
País:España
Institución:Universitat Pompeu Fabra
Repositorio:Repositorio Digital de la UPF
OAI Identifier:oai:repositori.upf.edu:10230/34925
Acceso en línea:http://hdl.handle.net/10230/34925
http://dx.doi.org/10.1016/j.mod.2016.12.005
Access Level:acceso abierto
Palabra clave:Dorsal closure
Embryonic development
Embryo
Drosophila proteins
Drosophila melanogaster
Body patterning
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spelling Drosophila dorsal closure: An orchestra of forces to zip shut the embryoHayes, D. Peran, 1983-Solon, JérômeDorsal closureEmbryonic developmentEmbryoDrosophila proteinsDrosophila melanogasterBody patterningDorsal closure, a late-embryogenesis process, consists in the sealing of an epidermal gap on the dorsal side of the Drosophila embryo. Because of its similarities with wound healing and neural tube closure in humans, it has been extensively studied in the last twenty years. The process requires the coordination of several force generating mechanisms, that together will zip shut the epidermis. Recent works have provided a precise description of the cellular behavior at the origin of these forces and proposed quantitative models of the process. In this review, we will describe the different forces acting in dorsal closure. We will present our current knowledge on the mechanisms generating and regulating these forces and report on the different quantitative mathematical models proposed so far.The research in the Solon lab is granted by the Spanish Ministry of Economy and Competitiveness, Plan Nacional, BFU2010-16546 and 'Centro de Excelencia Severo Ochoa 2013-2017', SEV-2012-0208 and P.H. has received a fellowship from 'La Caixa' PhD program. We acknowledge the support of the CERCA Programme/Generalitat de Catalunya.Elsevier201820182017info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfapplication/pdfhttp://hdl.handle.net/10230/34925http://dx.doi.org/10.1016/j.mod.2016.12.005reponame:Repositorio Digital de la UPFinstname:Universitat Pompeu FabraInglésMechanisms of Development. 2017 Apr;144(Pt A):2-10info:eu-repo/grantAgreement/ES/3PN/BFU2010-16546© 2017 The Authors. Published by Elsevier Ireland Ltd. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).http://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/openAccessoai:repositori.upf.edu:10230/349252026-06-12T07:21:37Z
dc.title.none.fl_str_mv Drosophila dorsal closure: An orchestra of forces to zip shut the embryo
title Drosophila dorsal closure: An orchestra of forces to zip shut the embryo
spellingShingle Drosophila dorsal closure: An orchestra of forces to zip shut the embryo
Hayes, D. Peran, 1983-
Dorsal closure
Embryonic development
Embryo
Drosophila proteins
Drosophila melanogaster
Body patterning
title_short Drosophila dorsal closure: An orchestra of forces to zip shut the embryo
title_full Drosophila dorsal closure: An orchestra of forces to zip shut the embryo
title_fullStr Drosophila dorsal closure: An orchestra of forces to zip shut the embryo
title_full_unstemmed Drosophila dorsal closure: An orchestra of forces to zip shut the embryo
title_sort Drosophila dorsal closure: An orchestra of forces to zip shut the embryo
dc.creator.none.fl_str_mv Hayes, D. Peran, 1983-
Solon, Jérôme
author Hayes, D. Peran, 1983-
author_facet Hayes, D. Peran, 1983-
Solon, Jérôme
author_role author
author2 Solon, Jérôme
author2_role author
dc.subject.none.fl_str_mv Dorsal closure
Embryonic development
Embryo
Drosophila proteins
Drosophila melanogaster
Body patterning
topic Dorsal closure
Embryonic development
Embryo
Drosophila proteins
Drosophila melanogaster
Body patterning
description Dorsal closure, a late-embryogenesis process, consists in the sealing of an epidermal gap on the dorsal side of the Drosophila embryo. Because of its similarities with wound healing and neural tube closure in humans, it has been extensively studied in the last twenty years. The process requires the coordination of several force generating mechanisms, that together will zip shut the epidermis. Recent works have provided a precise description of the cellular behavior at the origin of these forces and proposed quantitative models of the process. In this review, we will describe the different forces acting in dorsal closure. We will present our current knowledge on the mechanisms generating and regulating these forces and report on the different quantitative mathematical models proposed so far.
publishDate 2017
dc.date.none.fl_str_mv 2017
2018
2018
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10230/34925
http://dx.doi.org/10.1016/j.mod.2016.12.005
url http://hdl.handle.net/10230/34925
http://dx.doi.org/10.1016/j.mod.2016.12.005
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Mechanisms of Development. 2017 Apr;144(Pt A):2-10
info:eu-repo/grantAgreement/ES/3PN/BFU2010-16546
dc.rights.none.fl_str_mv http://creativecommons.org/licenses/by-nc-nd/4.0/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv http://creativecommons.org/licenses/by-nc-nd/4.0/
eu_rights_str_mv openAccess
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dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:Repositorio Digital de la UPF
instname:Universitat Pompeu Fabra
instname_str Universitat Pompeu Fabra
reponame_str Repositorio Digital de la UPF
collection Repositorio Digital de la UPF
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repository.mail.fl_str_mv
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