The effect of aneuploidy on embryonic development in Drosophila melanogaster
We have investigated the embryonic mortality and lethal effective phase of zygotes generated from crosses of deletion and translocation heterozygotes. The results show that (1) zygotes heterozygous for large deletions derived from the male gamete hatch as larvae or die late in embryogenesis; (2) the...
| Autores: | , , |
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| Tipo de recurso: | artículo |
| Fecha de publicación: | 1983 |
| País: | España |
| Institución: | Consejo Superior de Investigaciones Científicas (CSIC) |
| Repositorio: | DIGITAL.CSIC. Repositorio Institucional del CSIC |
| OAI Identifier: | oai:digital.csic.es:10261/47699 |
| Acceso en línea: | http://hdl.handle.net/10261/47699 |
| Access Level: | acceso embargado |
| Palabra clave: | Drosophila Melanogaster Embryo Zygote |
| Sumario: | We have investigated the embryonic mortality and lethal effective phase of zygotes generated from crosses of deletion and translocation heterozygotes. The results show that (1) zygotes heterozygous for large deletions derived from the male gamete hatch as larvae or die late in embryogenesis; (2) there is significant mortality in eggs derived from some heterozygous deletion females and (3) embryos homozygous for some large deletions, and most small ones, die late in embryogenesis after completion of segmentation and cuticular differentiation. This conclusion applies to deletions up to 12% of the genome. Deletions for particular chromosome regions (genes) may show characteristic phenotypes. Aneuploid zygotes resulting from segregation of translocations generally show late embryonic mortality. The results indicate that maternal gene products released in the oocyte are sufficient and, in part, necessary for normal segmentation and cuticular differentiation during embryogenesis. The implications of these findings on studies of phase and tissue specificity of gene action are discussed. |
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