TMAO and Gut Microbial-Derived Metabolites TML and γBB Are Not Associated with Thrombotic Risk in Patients with Venous Thromboembolism

Background: The present work evaluates the association between circulating concentrations of Trimethylamine-N-oxide (TMAO), gamma butyrobetaine (gamma BB), and trimetyllisine (TML) in controls and patients with venous thromboembolism (VTE) with coagulation parameters. Methods: The study involved 54...

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Autores: Canyelles, Marina, Plaza, Melania, Rotllan, Noemi, Llobet i Lorente, Ma. Dolors, Julve, Josep, Mojal, Sergi, Diaz Ricart, M. Isabel, Soria, José Manuel, Escolà Gil, Joan Carles, Tondo i Colomer, Mireia, Blanco Vaca, Francisco, Souto Andrés, Juan Carlos
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2023
País:España
Institución:Universidad de Barcelona
Repositorio:Dipòsit Digital de la UB
OAI Identifier:oai:diposit.ub.edu:2445/209285
Acceso en línea:https://hdl.handle.net/2445/209285
Access Level:acceso abierto
Palabra clave:Tromboembolisme
Espectroscòpia
Thromboembolism
Spectrum analysis
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spelling TMAO and Gut Microbial-Derived Metabolites TML and γBB Are Not Associated with Thrombotic Risk in Patients with Venous ThromboembolismCanyelles, MarinaPlaza, MelaniaRotllan, NoemiLlobet i Lorente, Ma. DolorsJulve, JosepMojal, SergiDiaz Ricart, M. IsabelSoria, José ManuelEscolà Gil, Joan CarlesTondo i Colomer, MireiaBlanco Vaca, FranciscoSouto Andrés, Juan CarlosTromboembolismeEspectroscòpiaThromboembolismSpectrum analysisBackground: The present work evaluates the association between circulating concentrations of Trimethylamine-N-oxide (TMAO), gamma butyrobetaine (gamma BB), and trimetyllisine (TML) in controls and patients with venous thromboembolism (VTE) with coagulation parameters. Methods: The study involved 54 VTE patients and 57 controls. Platelet function, platelet hyperreactivity, platelet adhesiveness, thrombosis-associated parameters, and thrombin generation parameters were studied. Plasma TMAO, gamma BB, and TML determination was performed using an ultra-high-performance liquid chromatography system coupled with mass spectrometry. Results: No differences were found for TMAO, gamma BB, or TML concentrations between controls and VTE patients. In thrombin generation tests, TMAO, gamma BB, and TML showed a positive correlation with lag time and time to peak. TMAO, gamma BB, and TML negatively correlated with peak height. No significant differences were observed regarding TMAO, gamma BB, and TML concentrations between the two blood withdrawals, nor when the control and VTE patients were analyzed separately. No correlation was observed between these gut metabolites and platelet function parameters. Conclusions: No differences were found regarding TMAO, gamma BB, and TML concentrations between the control and VTE groups. Some correlations were found; however, they were mild or went in the opposite direction of what would be expected if TMAO and its derivatives were related to VTE risk.MDPI20232023info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://hdl.handle.net/2445/209285Articles publicats en revistes (IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer)reponame:Dipòsit Digital de la UBinstname:Universidad de BarcelonaInglésReproducció del document publicat a: https://doi.org/10.3390/jcm11051425Journal Of Clinical Medicine, 2022, vol. 11, num. 5,https://doi.org/10.3390/jcm11051425cc by (c) Canyelles, Marina et al, 2022http://creativecommons.org/licenses/by/3.0/es/info:eu-repo/semantics/openAccessoai:diposit.ub.edu:2445/2092852026-05-27T06:46:51Z
dc.title.none.fl_str_mv TMAO and Gut Microbial-Derived Metabolites TML and γBB Are Not Associated with Thrombotic Risk in Patients with Venous Thromboembolism
title TMAO and Gut Microbial-Derived Metabolites TML and γBB Are Not Associated with Thrombotic Risk in Patients with Venous Thromboembolism
spellingShingle TMAO and Gut Microbial-Derived Metabolites TML and γBB Are Not Associated with Thrombotic Risk in Patients with Venous Thromboembolism
Canyelles, Marina
Tromboembolisme
Espectroscòpia
Thromboembolism
Spectrum analysis
title_short TMAO and Gut Microbial-Derived Metabolites TML and γBB Are Not Associated with Thrombotic Risk in Patients with Venous Thromboembolism
title_full TMAO and Gut Microbial-Derived Metabolites TML and γBB Are Not Associated with Thrombotic Risk in Patients with Venous Thromboembolism
title_fullStr TMAO and Gut Microbial-Derived Metabolites TML and γBB Are Not Associated with Thrombotic Risk in Patients with Venous Thromboembolism
title_full_unstemmed TMAO and Gut Microbial-Derived Metabolites TML and γBB Are Not Associated with Thrombotic Risk in Patients with Venous Thromboembolism
title_sort TMAO and Gut Microbial-Derived Metabolites TML and γBB Are Not Associated with Thrombotic Risk in Patients with Venous Thromboembolism
dc.creator.none.fl_str_mv Canyelles, Marina
Plaza, Melania
Rotllan, Noemi
Llobet i Lorente, Ma. Dolors
Julve, Josep
Mojal, Sergi
Diaz Ricart, M. Isabel
Soria, José Manuel
Escolà Gil, Joan Carles
Tondo i Colomer, Mireia
Blanco Vaca, Francisco
Souto Andrés, Juan Carlos
author Canyelles, Marina
author_facet Canyelles, Marina
Plaza, Melania
Rotllan, Noemi
Llobet i Lorente, Ma. Dolors
Julve, Josep
Mojal, Sergi
Diaz Ricart, M. Isabel
Soria, José Manuel
Escolà Gil, Joan Carles
Tondo i Colomer, Mireia
Blanco Vaca, Francisco
Souto Andrés, Juan Carlos
author_role author
author2 Plaza, Melania
Rotllan, Noemi
Llobet i Lorente, Ma. Dolors
Julve, Josep
Mojal, Sergi
Diaz Ricart, M. Isabel
Soria, José Manuel
Escolà Gil, Joan Carles
Tondo i Colomer, Mireia
Blanco Vaca, Francisco
Souto Andrés, Juan Carlos
author2_role author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Tromboembolisme
Espectroscòpia
Thromboembolism
Spectrum analysis
topic Tromboembolisme
Espectroscòpia
Thromboembolism
Spectrum analysis
description Background: The present work evaluates the association between circulating concentrations of Trimethylamine-N-oxide (TMAO), gamma butyrobetaine (gamma BB), and trimetyllisine (TML) in controls and patients with venous thromboembolism (VTE) with coagulation parameters. Methods: The study involved 54 VTE patients and 57 controls. Platelet function, platelet hyperreactivity, platelet adhesiveness, thrombosis-associated parameters, and thrombin generation parameters were studied. Plasma TMAO, gamma BB, and TML determination was performed using an ultra-high-performance liquid chromatography system coupled with mass spectrometry. Results: No differences were found for TMAO, gamma BB, or TML concentrations between controls and VTE patients. In thrombin generation tests, TMAO, gamma BB, and TML showed a positive correlation with lag time and time to peak. TMAO, gamma BB, and TML negatively correlated with peak height. No significant differences were observed regarding TMAO, gamma BB, and TML concentrations between the two blood withdrawals, nor when the control and VTE patients were analyzed separately. No correlation was observed between these gut metabolites and platelet function parameters. Conclusions: No differences were found regarding TMAO, gamma BB, and TML concentrations between the control and VTE groups. Some correlations were found; however, they were mild or went in the opposite direction of what would be expected if TMAO and its derivatives were related to VTE risk.
publishDate 2023
dc.date.none.fl_str_mv 2023
2023
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/209285
url https://hdl.handle.net/2445/209285
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Reproducció del document publicat a: https://doi.org/10.3390/jcm11051425
Journal Of Clinical Medicine, 2022, vol. 11, num. 5,
https://doi.org/10.3390/jcm11051425
dc.rights.none.fl_str_mv cc by (c) Canyelles, Marina et al, 2022
http://creativecommons.org/licenses/by/3.0/es/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv cc by (c) Canyelles, Marina et al, 2022
http://creativecommons.org/licenses/by/3.0/es/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv Articles publicats en revistes (IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer)
reponame:Dipòsit Digital de la UB
instname:Universidad de Barcelona
instname_str Universidad de Barcelona
reponame_str Dipòsit Digital de la UB
collection Dipòsit Digital de la UB
repository.name.fl_str_mv
repository.mail.fl_str_mv
_version_ 1869419827567788032
score 15,301603

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