TMAO and Gut Microbial-Derived Metabolites TML and γBB Are Not Associated with Thrombotic Risk in Patients with Venous Thromboembolism

Background: The present work evaluates the association between circulating concentrations of Trimethylamine-N-oxide (TMAO), gamma butyrobetaine (γBB), and trimetyllisine (TML) in controls and patients with venous thromboembolism (VTE) with coagulation parameters. Methods: The study involved 54 VTE p...

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Detalles Bibliográficos
Autores: Canyelles, Marina|||0000-0002-0278-5337, Plaza, Melania|||0000-0002-1471-3672, Rotllan, Noemi|||0000-0002-0587-8045, Llobet, Dolors, Julve i Gil, Josep|||0000-0002-6531-2246, Mojal, Sergi|||0000-0003-0523-3869, Diaz-Ricart, Maribel|||0000-0003-1122-0052, Soria Fernández, José Manuel|||0000-0002-6226-4293, Escolà-Gil, Joan Carles|||0000-0001-9021-2485, Tondo Colomer, Mireia|||0000-0002-0301-9984, Blanco Vaca, Francisco|||0000-0001-7380-5385, Souto, Juan Carlos|||0000-0003-2092-5142
Tipo de recurso: artículo
Fecha de publicación:2022
País:España
Institución:Universitat Autònoma de Barcelona
Repositorio:Dipòsit Digital de Documents de la UAB
Idioma:inglés
OAI Identifier:oai:ddd.uab.cat:258937
Acceso en línea:https://ddd.uab.cat/record/258937
https://dx.doi.org/urn:doi:10.3390/jcm11051425
Access Level:acceso abierto
Palabra clave:Trimethylamine N-oxide
TMAO
γBB
TML
Liquid chromatography-mass spectrometry
Venous thromboembolism
Descripción
Sumario:Background: The present work evaluates the association between circulating concentrations of Trimethylamine-N-oxide (TMAO), gamma butyrobetaine (γBB), and trimetyllisine (TML) in controls and patients with venous thromboembolism (VTE) with coagulation parameters. Methods: The study involved 54 VTE patients and 57 controls. Platelet function, platelet hyperreactivity, platelet adhesiveness, thrombosis-associated parameters, and thrombin generation parameters were studied. Plasma TMAO, γBB, and TML determination was performed using an ultra-high-performance liquid chromatography system coupled with mass spectrometry. Results: No differences were found for TMAO, γBB, or TML concentrations between controls and VTE patients. In thrombin generation tests, TMAO, γBB, and TML showed a positive correlation with lag time and time to peak. TMAO, γBB, and TML negatively correlated with peak height. No significant differences were observed regarding TMAO, γBB, and TML concentrations between the two blood withdrawals, nor when the control and VTE patients were analyzed separately. No correlation was observed between these gut metabolites and platelet function parameters. Conclusions: No differences were found regarding TMAO, γBB, and TML concentrations between the control and VTE groups. Some correlations were found; however, they were mild or went in the opposite direction of what would be expected if TMAO and its derivatives were related to VTE risk.

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