Metabolically Active, Fully Hydrolysable Polymersomes

The synthesis and aqueous self-assembly of a new class of amphiphilic aliphatic polyesters are presented. These AB block polyesters comprise polycaprolactone (hydrophobe) and an alternating polyester from succinic acid and an ether-substituted epoxide (hydrophile). They self-assemble into biodegrada...

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Autores: Zhu, Yunqing, Poma, Alessandro, Rizzello, Loris, Gouveia, Virginia M., Ruiz‐Perez, Lorena, Battaglia, Giuseppe, Williams, Charlotte K.
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2019
País:España
Institución:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositorio:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:2445/216542
Acceso en línea:https://hdl.handle.net/2445/216542
Access Level:acceso abierto
Palabra clave:Agents tensioactius
Polièsters
Química
Surface active agents
Polyesters
Chemistry
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spelling Metabolically Active, Fully Hydrolysable PolymersomesZhu, YunqingPoma, AlessandroRizzello, LorisGouveia, Virginia M.Ruiz‐Perez, LorenaBattaglia, GiuseppeWilliams, Charlotte K.Agents tensioactiusPolièstersQuímicaSurface active agentsPolyestersChemistryThe synthesis and aqueous self-assembly of a new class of amphiphilic aliphatic polyesters are presented. These AB block polyesters comprise polycaprolactone (hydrophobe) and an alternating polyester from succinic acid and an ether-substituted epoxide (hydrophile). They self-assemble into biodegradable polymersomes capable of entering cells. Their degradation products are bioactive, giving rise to differentiated cellular responses inducing stromal cell proliferation and macrophage apoptosis. Both effects emerge only when the copolymers enter cells as polymersomes and their magnitudes are size dependent.Wiley-VCH2024202420192024info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion6 p.application/pdfhttps://hdl.handle.net/2445/216542Articles publicats en revistes (Física Aplicada)reponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésReproducció del document publicat a: https://doi.org/https://doi.org/10.1002/anie.201814320Angewandte Chemie-International Edition, 2019, vol. 58, num.14, p. 4581-4586https://doi.org/https://doi.org/10.1002/anie.201814320cc-by (c) Zhu, Yunqing, et al., 2019http://creativecommons.org/licenses/by/3.0/es/info:eu-repo/semantics/openAccessoai:recercat.cat:2445/2165422026-05-29T05:05:01Z
dc.title.none.fl_str_mv Metabolically Active, Fully Hydrolysable Polymersomes
title Metabolically Active, Fully Hydrolysable Polymersomes
spellingShingle Metabolically Active, Fully Hydrolysable Polymersomes
Zhu, Yunqing
Agents tensioactius
Polièsters
Química
Surface active agents
Polyesters
Chemistry
title_short Metabolically Active, Fully Hydrolysable Polymersomes
title_full Metabolically Active, Fully Hydrolysable Polymersomes
title_fullStr Metabolically Active, Fully Hydrolysable Polymersomes
title_full_unstemmed Metabolically Active, Fully Hydrolysable Polymersomes
title_sort Metabolically Active, Fully Hydrolysable Polymersomes
dc.creator.none.fl_str_mv Zhu, Yunqing
Poma, Alessandro
Rizzello, Loris
Gouveia, Virginia M.
Ruiz‐Perez, Lorena
Battaglia, Giuseppe
Williams, Charlotte K.
author Zhu, Yunqing
author_facet Zhu, Yunqing
Poma, Alessandro
Rizzello, Loris
Gouveia, Virginia M.
Ruiz‐Perez, Lorena
Battaglia, Giuseppe
Williams, Charlotte K.
author_role author
author2 Poma, Alessandro
Rizzello, Loris
Gouveia, Virginia M.
Ruiz‐Perez, Lorena
Battaglia, Giuseppe
Williams, Charlotte K.
author2_role author
author
author
author
author
author
dc.subject.none.fl_str_mv Agents tensioactius
Polièsters
Química
Surface active agents
Polyesters
Chemistry
topic Agents tensioactius
Polièsters
Química
Surface active agents
Polyesters
Chemistry
description The synthesis and aqueous self-assembly of a new class of amphiphilic aliphatic polyesters are presented. These AB block polyesters comprise polycaprolactone (hydrophobe) and an alternating polyester from succinic acid and an ether-substituted epoxide (hydrophile). They self-assemble into biodegradable polymersomes capable of entering cells. Their degradation products are bioactive, giving rise to differentiated cellular responses inducing stromal cell proliferation and macrophage apoptosis. Both effects emerge only when the copolymers enter cells as polymersomes and their magnitudes are size dependent.
publishDate 2019
dc.date.none.fl_str_mv 2019
2024
2024
2024
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/216542
url https://hdl.handle.net/2445/216542
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Reproducció del document publicat a: https://doi.org/https://doi.org/10.1002/anie.201814320
Angewandte Chemie-International Edition, 2019, vol. 58, num.14, p. 4581-4586
https://doi.org/https://doi.org/10.1002/anie.201814320
dc.rights.none.fl_str_mv cc-by (c) Zhu, Yunqing, et al., 2019
http://creativecommons.org/licenses/by/3.0/es/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv cc-by (c) Zhu, Yunqing, et al., 2019
http://creativecommons.org/licenses/by/3.0/es/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 6 p.
application/pdf
dc.publisher.none.fl_str_mv Wiley-VCH
publisher.none.fl_str_mv Wiley-VCH
dc.source.none.fl_str_mv Articles publicats en revistes (Física Aplicada)
reponame:Recercat. Dipósit de la Recerca de Catalunya
instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
instname_str Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
reponame_str Recercat. Dipósit de la Recerca de Catalunya
collection Recercat. Dipósit de la Recerca de Catalunya
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15.812429

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