Oxidation of unactivated C-H bonds catalyzed by manganese complexes: control over site-selectivity and enantioselectivity
The oxidation of aliphatic C-H bonds is a very powerful reaction because it allows the functionalization of inert C-H bonds, converting them into a suitable sites for further chemical elaboration. It also represents one of the most challenging reactions in modern synthetic organic chemistry because...
| Autor: | |
|---|---|
| Tipo de recurso: | tesis doctoral |
| Estado: | Versión publicada |
| Fecha de publicación: | 2018 |
| País: | España |
| Institución: | CBUC, CESCA |
| Repositorio: | TDR. Tesis Doctorales en Red |
| OAI Identifier: | oai:www.tdx.cat:10803/664865 |
| Acceso en línea: | http://hdl.handle.net/10803/664865 |
| Access Level: | acceso abierto |
| Palabra clave: | C-H oxidation Oxidació de CH Oxidación de CH Manganeses complexes Complexos de manganès Complejos de manganeso Bioinspired models Models bioinspirats Modelos bioinspirados Metal catalysts Catalitzadors de metalls Catalizadores de metales 546 |
| Sumario: | The oxidation of aliphatic C-H bonds is a very powerful reaction because it allows the functionalization of inert C-H bonds, converting them into a suitable sites for further chemical elaboration. It also represents one of the most challenging reactions in modern synthetic organic chemistry because the multitude of aliphatic C-H bonds in a molecule makes site selective oxidation particularly difficult. Moreover, the introduction of chirality represents an unmet but very appealing challenge, because the asymmetric oxidation of hydrocarbons produces chiral compounds of high value in organic synthesis from readily available starting materials. Until now, examples of enantioselective oxidation of nonactivated aliphatic C-H bonds remain exclusive to enzymes. This thesis has been devoted to the development of new catalytic systems capable to oxidize nonactivated aliphatic C-H bonds in a site-selective and enantioselective manner. In particularly, chemo- and enantioselective aliphatic C-H oxidation reactions, especially focused in amide containing substrates have been developed. |
|---|