Incidence and clearance of anal high-risk human papillomavirus in HIV-positive men who have sex with men: Estimates and risk factors
Background: To estimate incidence and clearance of high-risk human papillomavirus (HR-HPV), and their risk factors, in men who have sex with men (MSM) recently infected by HIV in Spain; 2007-2013. Methods: Multicenter cohort. HR-HPV infection was determined and genotyped with linear array. Two-state...
| Autores: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
|---|---|
| Tipo de recurso: | artículo |
| Fecha de publicación: | 2016 |
| País: | España |
| Institución: | Universidad Autónoma de Madrid |
| Repositorio: | Biblos-e Archivo. Repositorio Institucional de la UAM |
| Idioma: | inglés |
| OAI Identifier: | oai:repositorio.uam.es:10486/714935 |
| Acceso en línea: | http://hdl.handle.net/10486/714935 https://dx.doi.org/10.1097/QAD.0000000000000874 |
| Access Level: | acceso abierto |
| Palabra clave: | clearance HIV human papillomavirus incidence men who have sex with men Medicina |
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Incidence and clearance of anal high-risk human papillomavirus in HIV-positive men who have sex with men: Estimates and risk factorsGeskus, Ronald B.González Blázquez, CristinaTorres, MontserratDel Romero, JorgeViciana, PompeyoMasiá, MarBlanco, Jose RamónIribarren, Gustavo MauricioDe Sanjosé, SilviaHernández-Novoa, BeatrizOrtiz, MartaDel Amo, JuliaPena, AlejandroGarcia, FedericoOcampo, AntonioDa Silva, Alfredo RodriguezMiralles, CeliaGonzalez-Carrero, JoaquinMadrid, NadiaBenito, AmparoSanz, ItziarVera, MarRodriguez, CarmenPuerta, TeresaCarrio, Juan CarlosRaposo, MontserratTrastoy, MonicaFontillon, MariaRobledano, CatalinaGutierrez, FelixPadilla, SergioAndrada, EncarnaCervero, MiguelPerez, LauraPortilla, JoaquinPortilla, IreneVonwichmann, Miguel AngelIribarren, Jose AntonioCamino, XabierSendagorta Cudós, Elena MaríaHerranz Pinto, Pedro FranciscoRodriguez, PatriciaGomez, Juan LuisRosado, DacilRodriguez-Arenas, M. AngelesAlejos, BelenSobrino-Vegas, PazclearanceHIVhuman papillomavirusincidencemen who have sex with menMedicinaBackground: To estimate incidence and clearance of high-risk human papillomavirus (HR-HPV), and their risk factors, in men who have sex with men (MSM) recently infected by HIV in Spain; 2007-2013. Methods: Multicenter cohort. HR-HPV infection was determined and genotyped with linear array. Two-state Markov models and Poisson regression were used. Results: We analysed 1570 HR-HPV measurements of 612 MSM over 13 608 person-months (p-m) of follow-up. Median (mean) number of measurements was 2 (2.6), median time interval between measurements was 1.1 years (interquartile range: 0.89-1.4). Incidence ranged from 9.0 [95% confidence interval (CI) 6.8-11.8] per 1000 p-m for HPV59 to 15.9 (11.7-21.8) per 1000 p-m for HPV51. HPV16 and HPV18 had slightly above average incidence: 11.9/1000 p-m and 12.8/1000 p-m. HPV16 showed the lowest clearance for both 'prevalent positive' (15.7/1000 p-m; 95% CI 12.0-20.5) and 'incident positive' infections (22.1/1000 p-m; 95% CI 11.8-41.1). More sexual partners increased HR-HPV incidence, although it was not statistically significant. Age had a strong effect on clearance (P-value < 0.001) due to the elevated rate in MSM under age 25; the effect of HIV-RNA viral load was more gradual, with clearance rate decreasing at higher HIV-RNA viral load (P-value 0.008). Conclusion: No large variation in incidence by HR-HPV type was seen. The most common incident types were HPV51, HPV52, HPV31, HPV18 and HPV16. No major variation in clearance by type was observed, with the exception of HPV16 which had the highest persistence and potentially, the strongest oncogenic capacity. Those aged below 25 or with low HIV-RNA- viral load had the highest clearanceThis work was supported by grants from the Fondo de Investigacio´n Sanitaria [PI06/0372, PS09/2181], Red de Investigacio´n en SIDA (RIS) [RD06/006/0026 and RD12/0017/0018 to C.G.] and CIBERESP [group 54A-CB06/02/1009]Lippincott, Williams & WilkinsDepartamento de EnfermeríaFacultad de Medicina20162016-01-02research articlehttp://purl.org/coar/resource_type/c_2df8fbb1VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10486/714935https://dx.doi.org/10.1097/QAD.0000000000000874reponame:Biblos-e Archivo. Repositorio Institucional de la UAMinstname:Universidad Autónoma de MadridInglésengopen accesshttp://purl.org/coar/access_right/c_abf2Attribution-NonCommercial-NoDerivatives 4.0 Internationalhttp://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/openAccessoai:repositorio.uam.es:10486/7149352026-06-23T12:46:27Z |
| dc.title.none.fl_str_mv |
Incidence and clearance of anal high-risk human papillomavirus in HIV-positive men who have sex with men: Estimates and risk factors |
| title |
Incidence and clearance of anal high-risk human papillomavirus in HIV-positive men who have sex with men: Estimates and risk factors |
| spellingShingle |
Incidence and clearance of anal high-risk human papillomavirus in HIV-positive men who have sex with men: Estimates and risk factors Geskus, Ronald B. clearance HIV human papillomavirus incidence men who have sex with men Medicina |
| title_short |
Incidence and clearance of anal high-risk human papillomavirus in HIV-positive men who have sex with men: Estimates and risk factors |
| title_full |
Incidence and clearance of anal high-risk human papillomavirus in HIV-positive men who have sex with men: Estimates and risk factors |
| title_fullStr |
Incidence and clearance of anal high-risk human papillomavirus in HIV-positive men who have sex with men: Estimates and risk factors |
| title_full_unstemmed |
Incidence and clearance of anal high-risk human papillomavirus in HIV-positive men who have sex with men: Estimates and risk factors |
| title_sort |
Incidence and clearance of anal high-risk human papillomavirus in HIV-positive men who have sex with men: Estimates and risk factors |
| dc.creator.none.fl_str_mv |
Geskus, Ronald B. González Blázquez, Cristina Torres, Montserrat Del Romero, Jorge Viciana, Pompeyo Masiá, Mar Blanco, Jose Ramón Iribarren, Gustavo Mauricio De Sanjosé, Silvia Hernández-Novoa, Beatriz Ortiz, Marta Del Amo, Julia Pena, Alejandro Garcia, Federico Ocampo, Antonio Da Silva, Alfredo Rodriguez Miralles, Celia Gonzalez-Carrero, Joaquin Madrid, Nadia Benito, Amparo Sanz, Itziar Vera, Mar Rodriguez, Carmen Puerta, Teresa Carrio, Juan Carlos Raposo, Montserrat Trastoy, Monica Fontillon, Maria Robledano, Catalina Gutierrez, Felix Padilla, Sergio Andrada, Encarna Cervero, Miguel Perez, Laura Portilla, Joaquin Portilla, Irene Vonwichmann, Miguel Angel Iribarren, Jose Antonio Camino, Xabier Sendagorta Cudós, Elena María Herranz Pinto, Pedro Francisco Rodriguez, Patricia Gomez, Juan Luis Rosado, Dacil Rodriguez-Arenas, M. Angeles Alejos, Belen Sobrino-Vegas, Paz |
| author |
Geskus, Ronald B. |
| author_facet |
Geskus, Ronald B. González Blázquez, Cristina Torres, Montserrat Del Romero, Jorge Viciana, Pompeyo Masiá, Mar Blanco, Jose Ramón Iribarren, Gustavo Mauricio De Sanjosé, Silvia Hernández-Novoa, Beatriz Ortiz, Marta Del Amo, Julia Pena, Alejandro Garcia, Federico Ocampo, Antonio Da Silva, Alfredo Rodriguez Miralles, Celia Gonzalez-Carrero, Joaquin Madrid, Nadia Benito, Amparo Sanz, Itziar Vera, Mar Rodriguez, Carmen Puerta, Teresa Carrio, Juan Carlos Raposo, Montserrat Trastoy, Monica Fontillon, Maria Robledano, Catalina Gutierrez, Felix Padilla, Sergio Andrada, Encarna Cervero, Miguel Perez, Laura Portilla, Joaquin Portilla, Irene Vonwichmann, Miguel Angel Iribarren, Jose Antonio Camino, Xabier Sendagorta Cudós, Elena María Herranz Pinto, Pedro Francisco Rodriguez, Patricia Gomez, Juan Luis Rosado, Dacil Rodriguez-Arenas, M. Angeles Alejos, Belen Sobrino-Vegas, Paz |
| author_role |
author |
| author2 |
González Blázquez, Cristina Torres, Montserrat Del Romero, Jorge Viciana, Pompeyo Masiá, Mar Blanco, Jose Ramón Iribarren, Gustavo Mauricio De Sanjosé, Silvia Hernández-Novoa, Beatriz Ortiz, Marta Del Amo, Julia Pena, Alejandro Garcia, Federico Ocampo, Antonio Da Silva, Alfredo Rodriguez Miralles, Celia Gonzalez-Carrero, Joaquin Madrid, Nadia Benito, Amparo Sanz, Itziar Vera, Mar Rodriguez, Carmen Puerta, Teresa Carrio, Juan Carlos Raposo, Montserrat Trastoy, Monica Fontillon, Maria Robledano, Catalina Gutierrez, Felix Padilla, Sergio Andrada, Encarna Cervero, Miguel Perez, Laura Portilla, Joaquin Portilla, Irene Vonwichmann, Miguel Angel Iribarren, Jose Antonio Camino, Xabier Sendagorta Cudós, Elena María Herranz Pinto, Pedro Francisco Rodriguez, Patricia Gomez, Juan Luis Rosado, Dacil Rodriguez-Arenas, M. Angeles Alejos, Belen Sobrino-Vegas, Paz |
| author2_role |
author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author |
| dc.contributor.none.fl_str_mv |
Departamento de Enfermería Facultad de Medicina |
| dc.subject.none.fl_str_mv |
clearance HIV human papillomavirus incidence men who have sex with men Medicina |
| topic |
clearance HIV human papillomavirus incidence men who have sex with men Medicina |
| description |
Background: To estimate incidence and clearance of high-risk human papillomavirus (HR-HPV), and their risk factors, in men who have sex with men (MSM) recently infected by HIV in Spain; 2007-2013. Methods: Multicenter cohort. HR-HPV infection was determined and genotyped with linear array. Two-state Markov models and Poisson regression were used. Results: We analysed 1570 HR-HPV measurements of 612 MSM over 13 608 person-months (p-m) of follow-up. Median (mean) number of measurements was 2 (2.6), median time interval between measurements was 1.1 years (interquartile range: 0.89-1.4). Incidence ranged from 9.0 [95% confidence interval (CI) 6.8-11.8] per 1000 p-m for HPV59 to 15.9 (11.7-21.8) per 1000 p-m for HPV51. HPV16 and HPV18 had slightly above average incidence: 11.9/1000 p-m and 12.8/1000 p-m. HPV16 showed the lowest clearance for both 'prevalent positive' (15.7/1000 p-m; 95% CI 12.0-20.5) and 'incident positive' infections (22.1/1000 p-m; 95% CI 11.8-41.1). More sexual partners increased HR-HPV incidence, although it was not statistically significant. Age had a strong effect on clearance (P-value < 0.001) due to the elevated rate in MSM under age 25; the effect of HIV-RNA viral load was more gradual, with clearance rate decreasing at higher HIV-RNA viral load (P-value 0.008). Conclusion: No large variation in incidence by HR-HPV type was seen. The most common incident types were HPV51, HPV52, HPV31, HPV18 and HPV16. No major variation in clearance by type was observed, with the exception of HPV16 which had the highest persistence and potentially, the strongest oncogenic capacity. Those aged below 25 or with low HIV-RNA- viral load had the highest clearance |
| publishDate |
2016 |
| dc.date.none.fl_str_mv |
2016 2016-01-02 |
| dc.type.none.fl_str_mv |
research article http://purl.org/coar/resource_type/c_2df8fbb1 VoR http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| dc.type.openaire.fl_str_mv |
info:eu-repo/semantics/article |
| format |
article |
| dc.identifier.none.fl_str_mv |
http://hdl.handle.net/10486/714935 https://dx.doi.org/10.1097/QAD.0000000000000874 |
| url |
http://hdl.handle.net/10486/714935 https://dx.doi.org/10.1097/QAD.0000000000000874 |
| dc.language.none.fl_str_mv |
Inglés eng |
| language_invalid_str_mv |
Inglés |
| language |
eng |
| dc.rights.none.fl_str_mv |
open access http://purl.org/coar/access_right/c_abf2 Attribution-NonCommercial-NoDerivatives 4.0 International http://creativecommons.org/licenses/by-nc-nd/4.0/ |
| dc.rights.openaire.fl_str_mv |
info:eu-repo/semantics/openAccess |
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open access http://purl.org/coar/access_right/c_abf2 Attribution-NonCommercial-NoDerivatives 4.0 International http://creativecommons.org/licenses/by-nc-nd/4.0/ |
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openAccess |
| dc.format.none.fl_str_mv |
application/pdf |
| dc.publisher.none.fl_str_mv |
Lippincott, Williams & Wilkins |
| publisher.none.fl_str_mv |
Lippincott, Williams & Wilkins |
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reponame:Biblos-e Archivo. Repositorio Institucional de la UAM instname:Universidad Autónoma de Madrid |
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Universidad Autónoma de Madrid |
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Biblos-e Archivo. Repositorio Institucional de la UAM |
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Biblos-e Archivo. Repositorio Institucional de la UAM |
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15,812429 |