Incidence and clearance of anal high-risk human papillomavirus in HIV-positive men who have sex with men: Estimates and risk factors

Background: To estimate incidence and clearance of high-risk human papillomavirus (HR-HPV), and their risk factors, in men who have sex with men (MSM) recently infected by HIV in Spain; 2007-2013. Methods: Multicenter cohort. HR-HPV infection was determined and genotyped with linear array. Two-state...

Descripción completa

Detalles Bibliográficos
Autores: Geskus, Ronald B., González Blázquez, Cristina, Torres, Montserrat, Del Romero, Jorge, Viciana, Pompeyo, Masiá, Mar, Blanco, Jose Ramón, Iribarren, Gustavo Mauricio, De Sanjosé, Silvia, Hernández-Novoa, Beatriz, Ortiz, Marta, Del Amo, Julia, Pena, Alejandro, Garcia, Federico, Ocampo, Antonio, Da Silva, Alfredo Rodriguez, Miralles, Celia, Gonzalez-Carrero, Joaquin, Madrid, Nadia, Benito, Amparo, Sanz, Itziar, Vera, Mar, Rodriguez, Carmen, Puerta, Teresa, Carrio, Juan Carlos, Raposo, Montserrat, Trastoy, Monica, Fontillon, Maria, Robledano, Catalina, Gutierrez, Felix, Padilla, Sergio, Andrada, Encarna, Cervero, Miguel, Perez, Laura, Portilla, Joaquin, Portilla, Irene, Vonwichmann, Miguel Angel, Iribarren, Jose Antonio, Camino, Xabier, Sendagorta Cudós, Elena María, Herranz Pinto, Pedro Francisco, Rodriguez, Patricia, Gomez, Juan Luis, Rosado, Dacil, Rodriguez-Arenas, M. Angeles, Alejos, Belen, Sobrino-Vegas, Paz
Tipo de recurso: artículo
Fecha de publicación:2016
País:España
Institución:Universidad Autónoma de Madrid
Repositorio:Biblos-e Archivo. Repositorio Institucional de la UAM
Idioma:inglés
OAI Identifier:oai:repositorio.uam.es:10486/714935
Acceso en línea:http://hdl.handle.net/10486/714935
https://dx.doi.org/10.1097/QAD.0000000000000874
Access Level:acceso abierto
Palabra clave:clearance
HIV
human papillomavirus
incidence
men who have sex with men
Medicina
Descripción
Sumario:Background: To estimate incidence and clearance of high-risk human papillomavirus (HR-HPV), and their risk factors, in men who have sex with men (MSM) recently infected by HIV in Spain; 2007-2013. Methods: Multicenter cohort. HR-HPV infection was determined and genotyped with linear array. Two-state Markov models and Poisson regression were used. Results: We analysed 1570 HR-HPV measurements of 612 MSM over 13 608 person-months (p-m) of follow-up. Median (mean) number of measurements was 2 (2.6), median time interval between measurements was 1.1 years (interquartile range: 0.89-1.4). Incidence ranged from 9.0 [95% confidence interval (CI) 6.8-11.8] per 1000 p-m for HPV59 to 15.9 (11.7-21.8) per 1000 p-m for HPV51. HPV16 and HPV18 had slightly above average incidence: 11.9/1000 p-m and 12.8/1000 p-m. HPV16 showed the lowest clearance for both 'prevalent positive' (15.7/1000 p-m; 95% CI 12.0-20.5) and 'incident positive' infections (22.1/1000 p-m; 95% CI 11.8-41.1). More sexual partners increased HR-HPV incidence, although it was not statistically significant. Age had a strong effect on clearance (P-value < 0.001) due to the elevated rate in MSM under age 25; the effect of HIV-RNA viral load was more gradual, with clearance rate decreasing at higher HIV-RNA viral load (P-value 0.008). Conclusion: No large variation in incidence by HR-HPV type was seen. The most common incident types were HPV51, HPV52, HPV31, HPV18 and HPV16. No major variation in clearance by type was observed, with the exception of HPV16 which had the highest persistence and potentially, the strongest oncogenic capacity. Those aged below 25 or with low HIV-RNA- viral load had the highest clearance

Similares en LA Referencia