Low-energy nano-emulsification approach as a simple strategy to prepare positively charged ethylcellulose nanoparticles

Positively charged ethylcelulose nanoparticles have been obtained from alkylamidoammonium/Span 80 based nano-emulsion templates. Oil-in-water polymeric nano-emulsions form in a broad range of oil-to-surfactant ratios and water contents above 75 wt% by a low-energy method at 25 °C. Nano-emulsions wit...

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Autores: Leitner, S., Solans, Conxita, García-Celma, M. J., Calderó, Gabriela
Tipo de recurso: artículo
Estado:Versión aceptada para publicación
Fecha de publicación:2019
País:España
Institución:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/200998
Acceso en línea:http://hdl.handle.net/10261/200998
Access Level:acceso abierto
Palabra clave:Cationic nano-emulsion
Cationic nanoparticles
Ethylcellulose nanoparticles
Low-energy emulsifiaction
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spelling Low-energy nano-emulsification approach as a simple strategy to prepare positively charged ethylcellulose nanoparticlesLeitner, S.Solans, ConxitaGarcía-Celma, M. J.Calderó, GabrielaCationic nano-emulsionCationic nanoparticlesEthylcellulose nanoparticlesLow-energy emulsifiactionPositively charged ethylcelulose nanoparticles have been obtained from alkylamidoammonium/Span 80 based nano-emulsion templates. Oil-in-water polymeric nano-emulsions form in a broad range of oil-to-surfactant ratios and water contents above 75 wt% by a low-energy method at 25 °C. Nano-emulsions with a water content of 90 wt% showed droplet sizes typically below 300 nm and high positive zeta potential values (∼55 mV). If oleylamine is added to the system, smaller droplet sizes and higher zeta potential values (∼66 mV) are obtained, but the stability of the nano-emulsions decreases. Although these nano-emulsions are destabilized by creaming, the period of stability is large enough to allow nanoparticle preparation by solvent evaporation. Polymeric nanoparticles obtained show a globular core-shell-like morphology, with mean diameters of around 250 nm. The surface charge of the nanoparticles is similar to that of the nano-emulsion template and remains positive after 24 h dialysis, suggesting slow desorption kinetics of the alkylamidoammonium from the nanoparticle surface. These results indicate that the proposed nano-emulsion approach is a good strategy for the preparation of positively charged nanoparticles from nonionic ethylcellulose polymers. © 2018 Elsevier LtdFinancial support from MINECO (grant CTQ2011-29336-C03-01 ) and Generalitat de Catalunya (grant 2009SGR-961 ) is acknowledged. CIBER-BBN is an initiative funded by the VI National R&D&i Plan 2008-2011, Iniciativa Ingenio 2010, Consolider Program, CIBER Actions and financed by the Instituto de Salud Carlos III with assistance from the European Regional Development Fund . S.L. is grateful to CIBER-BBN for a research scholarship. The DLS and Zeta potential analyses have been performed at the Nanostructured Liquid Characterization Unit, located at the Institute of Advanced Chemistry of Catalonia (IQAC), belonging to the Spanish National Research Council (CSIC) and affiliated to the NANBIOSIS ICTS of the CIBER-BBN. Prof. M.L. García of the Dept. of Physical-Chemistry at the Univ. of Barcelona is gratefully acknowledged for facilitating the use of TurbiscanLab® Expert. GPC analysis has been carried out at the Unitat de Tècniques Separatives i Síntesi de Pèptids of the CCiT-UB (University of Barcelona). Colorcon and Bonderalia S.A./Quimivita S.A. are gratefully acknowledged for the gift of ethylcellulose and ricinoleamidopropyltrimonium methosulfate respectively. Appendix APeer reviewedElsevierMinisterio de Economía y Competitividad (España)Calderó, Gabriela [0000-0003-4827-7722]Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]202020202019info:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_6501Postprintinfo:eu-repo/semantics/acceptedVersionhttp://hdl.handle.net/10261/200998reponame:DIGITAL.CSIC. Repositorio Institucional del CSICinstname:Consejo Superior de Investigaciones Científicas (CSIC)InglésSíinfo:eu-repo/semantics/openAccessoai:digital.csic.es:10261/2009982026-05-22T06:33:51Z
dc.title.none.fl_str_mv Low-energy nano-emulsification approach as a simple strategy to prepare positively charged ethylcellulose nanoparticles
title Low-energy nano-emulsification approach as a simple strategy to prepare positively charged ethylcellulose nanoparticles
spellingShingle Low-energy nano-emulsification approach as a simple strategy to prepare positively charged ethylcellulose nanoparticles
Leitner, S.
Cationic nano-emulsion
Cationic nanoparticles
Ethylcellulose nanoparticles
Low-energy emulsifiaction
title_short Low-energy nano-emulsification approach as a simple strategy to prepare positively charged ethylcellulose nanoparticles
title_full Low-energy nano-emulsification approach as a simple strategy to prepare positively charged ethylcellulose nanoparticles
title_fullStr Low-energy nano-emulsification approach as a simple strategy to prepare positively charged ethylcellulose nanoparticles
title_full_unstemmed Low-energy nano-emulsification approach as a simple strategy to prepare positively charged ethylcellulose nanoparticles
title_sort Low-energy nano-emulsification approach as a simple strategy to prepare positively charged ethylcellulose nanoparticles
dc.creator.none.fl_str_mv Leitner, S.
Solans, Conxita
García-Celma, M. J.
Calderó, Gabriela
author Leitner, S.
author_facet Leitner, S.
Solans, Conxita
García-Celma, M. J.
Calderó, Gabriela
author_role author
author2 Solans, Conxita
García-Celma, M. J.
Calderó, Gabriela
author2_role author
author
author
dc.contributor.none.fl_str_mv Ministerio de Economía y Competitividad (España)
Calderó, Gabriela [0000-0003-4827-7722]
Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]
dc.subject.none.fl_str_mv Cationic nano-emulsion
Cationic nanoparticles
Ethylcellulose nanoparticles
Low-energy emulsifiaction
topic Cationic nano-emulsion
Cationic nanoparticles
Ethylcellulose nanoparticles
Low-energy emulsifiaction
description Positively charged ethylcelulose nanoparticles have been obtained from alkylamidoammonium/Span 80 based nano-emulsion templates. Oil-in-water polymeric nano-emulsions form in a broad range of oil-to-surfactant ratios and water contents above 75 wt% by a low-energy method at 25 °C. Nano-emulsions with a water content of 90 wt% showed droplet sizes typically below 300 nm and high positive zeta potential values (∼55 mV). If oleylamine is added to the system, smaller droplet sizes and higher zeta potential values (∼66 mV) are obtained, but the stability of the nano-emulsions decreases. Although these nano-emulsions are destabilized by creaming, the period of stability is large enough to allow nanoparticle preparation by solvent evaporation. Polymeric nanoparticles obtained show a globular core-shell-like morphology, with mean diameters of around 250 nm. The surface charge of the nanoparticles is similar to that of the nano-emulsion template and remains positive after 24 h dialysis, suggesting slow desorption kinetics of the alkylamidoammonium from the nanoparticle surface. These results indicate that the proposed nano-emulsion approach is a good strategy for the preparation of positively charged nanoparticles from nonionic ethylcellulose polymers. © 2018 Elsevier Ltd
publishDate 2019
dc.date.none.fl_str_mv 2019
2020
2020
dc.type.none.fl_str_mv info:eu-repo/semantics/article
http://purl.org/coar/resource_type/c_6501
Postprint
info:eu-repo/semantics/acceptedVersion
format article
status_str acceptedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10261/200998
url http://hdl.handle.net/10261/200998
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Sí
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:DIGITAL.CSIC. Repositorio Institucional del CSIC
instname:Consejo Superior de Investigaciones Científicas (CSIC)
instname_str Consejo Superior de Investigaciones Científicas (CSIC)
reponame_str DIGITAL.CSIC. Repositorio Institucional del CSIC
collection DIGITAL.CSIC. Repositorio Institucional del CSIC
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,81155

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