Economic burden of moderate to severe irritable bowel syndrome with constipation in six European countries

Irritable bowel syndrome with predominant constipation (IBS-C) is a complex disorder with gastrointestinal and nervous system components. The study aim was to assess the economic burden of moderate to severe IBS-C in six European countries (France, Germany, Italy, Spain, Sweden and the UK). An obser...

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Autores: Tack, Jan|||0000-0002-3206-6704, Stanghellini, Vincenzo|||0000-0003-0559-4875, Mearin, Fermín, Yiannakou, Yan, Layer, Peter, Coffin, Benoit|||0000-0002-0606-4158, Simren, Magnus, Mackinnon, Jonathan, Wiseman, Gwen, Marciniak, Anne, Brotons, Carlos|||0000-0001-9388-6581
Tipo de recurso: artículo
Fecha de publicación:2019
País:España
Institución:Universitat Autònoma de Barcelona
Repositorio:Dipòsit Digital de Documents de la UAB
Idioma:inglés
OAI Identifier:oai:ddd.uab.cat:286565
Acceso en línea:https://ddd.uab.cat/record/286565
https://dx.doi.org/urn:doi:10.1186/s12876-019-0985-1
Access Level:acceso abierto
Palabra clave:Economic Analysis
Europe
Healthcare resource utilisation
IBS
IBS-C
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spelling Economic burden of moderate to severe irritable bowel syndrome with constipation in six European countriesTack, Jan|||0000-0002-3206-6704Stanghellini, Vincenzo|||0000-0003-0559-4875Mearin, FermínYiannakou, YanLayer, PeterCoffin, Benoit|||0000-0002-0606-4158Simren, MagnusMackinnon, JonathanWiseman, GwenMarciniak, AnneBrotons, Carlos|||0000-0001-9388-6581Economic AnalysisEuropeHealthcare resource utilisationIBSIBS-CIrritable bowel syndrome with predominant constipation (IBS-C) is a complex disorder with gastrointestinal and nervous system components. The study aim was to assess the economic burden of moderate to severe IBS-C in six European countries (France, Germany, Italy, Spain, Sweden and the UK). An observational, one year retrospective-prospective (6 months each) study of patients diagnosed in the last five years with IBS-C (Rome III criteria) and moderate to severe disease at inclusion (IBS Symptom Severity Scale score ≥ 175). The primary objective was to assess the direct cost to European healthcare systems. Five hundred twenty-five patients were included, 60% (range: 43.1-78.8%) suffered from severe IBS-C. During follow-up 11.1-24.0% of patients had a hospitalisation/emergency room (ER) visit, median stay range: 1.5-12.0 days and 41.1-90.4% took prescription drugs for IBS-C. 21.4-50.8% of employed patients took sick leave (mean: 11.6-64.1 days). The mean annual direct cost to the healthcare systems was €937.1- €2108.0. The total direct cost (combined costs to healthcare systems and patient) for IBS-C was €1421.7-€2487.1. IBS-C is not a life-threatening condition; however, it has large impact on healthcare systems and society. Direct and indirect costs for moderate to severe IBS-C were high with the largest direct cost driver being hospitalisations/ER visits.Universitat Autònoma de Barcelona 22019-01-0120192019-01-01Articlehttp://purl.org/coar/resource_type/c_6501VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfhttps://ddd.uab.cat/record/286565https://dx.doi.org/urn:doi:10.1186/s12876-019-0985-1reponame:Dipòsit Digital de Documents de la UABinstname:Universitat Autònoma de BarcelonaInglésengopen accesshttp://purl.org/coar/access_right/c_abf2Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.https://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:ddd.uab.cat:2865652026-06-06T12:50:31Z
dc.title.none.fl_str_mv Economic burden of moderate to severe irritable bowel syndrome with constipation in six European countries
title Economic burden of moderate to severe irritable bowel syndrome with constipation in six European countries
spellingShingle Economic burden of moderate to severe irritable bowel syndrome with constipation in six European countries
Tack, Jan|||0000-0002-3206-6704
Economic Analysis
Europe
Healthcare resource utilisation
IBS
IBS-C
title_short Economic burden of moderate to severe irritable bowel syndrome with constipation in six European countries
title_full Economic burden of moderate to severe irritable bowel syndrome with constipation in six European countries
title_fullStr Economic burden of moderate to severe irritable bowel syndrome with constipation in six European countries
title_full_unstemmed Economic burden of moderate to severe irritable bowel syndrome with constipation in six European countries
title_sort Economic burden of moderate to severe irritable bowel syndrome with constipation in six European countries
dc.creator.none.fl_str_mv Tack, Jan|||0000-0002-3206-6704
Stanghellini, Vincenzo|||0000-0003-0559-4875
Mearin, Fermín
Yiannakou, Yan
Layer, Peter
Coffin, Benoit|||0000-0002-0606-4158
Simren, Magnus
Mackinnon, Jonathan
Wiseman, Gwen
Marciniak, Anne
Brotons, Carlos|||0000-0001-9388-6581
author Tack, Jan|||0000-0002-3206-6704
author_facet Tack, Jan|||0000-0002-3206-6704
Stanghellini, Vincenzo|||0000-0003-0559-4875
Mearin, Fermín
Yiannakou, Yan
Layer, Peter
Coffin, Benoit|||0000-0002-0606-4158
Simren, Magnus
Mackinnon, Jonathan
Wiseman, Gwen
Marciniak, Anne
Brotons, Carlos|||0000-0001-9388-6581
author_role author
author2 Stanghellini, Vincenzo|||0000-0003-0559-4875
Mearin, Fermín
Yiannakou, Yan
Layer, Peter
Coffin, Benoit|||0000-0002-0606-4158
Simren, Magnus
Mackinnon, Jonathan
Wiseman, Gwen
Marciniak, Anne
Brotons, Carlos|||0000-0001-9388-6581
author2_role author
author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Universitat Autònoma de Barcelona
dc.subject.none.fl_str_mv Economic Analysis
Europe
Healthcare resource utilisation
IBS
IBS-C
topic Economic Analysis
Europe
Healthcare resource utilisation
IBS
IBS-C
description Irritable bowel syndrome with predominant constipation (IBS-C) is a complex disorder with gastrointestinal and nervous system components. The study aim was to assess the economic burden of moderate to severe IBS-C in six European countries (France, Germany, Italy, Spain, Sweden and the UK). An observational, one year retrospective-prospective (6 months each) study of patients diagnosed in the last five years with IBS-C (Rome III criteria) and moderate to severe disease at inclusion (IBS Symptom Severity Scale score ≥ 175). The primary objective was to assess the direct cost to European healthcare systems. Five hundred twenty-five patients were included, 60% (range: 43.1-78.8%) suffered from severe IBS-C. During follow-up 11.1-24.0% of patients had a hospitalisation/emergency room (ER) visit, median stay range: 1.5-12.0 days and 41.1-90.4% took prescription drugs for IBS-C. 21.4-50.8% of employed patients took sick leave (mean: 11.6-64.1 days). The mean annual direct cost to the healthcare systems was €937.1- €2108.0. The total direct cost (combined costs to healthcare systems and patient) for IBS-C was €1421.7-€2487.1. IBS-C is not a life-threatening condition; however, it has large impact on healthcare systems and society. Direct and indirect costs for moderate to severe IBS-C were high with the largest direct cost driver being hospitalisations/ER visits.
publishDate 2019
dc.date.none.fl_str_mv 2
2019-01-01
2019
2019-01-01
dc.type.none.fl_str_mv Article
http://purl.org/coar/resource_type/c_6501
VoR
http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://ddd.uab.cat/record/286565
https://dx.doi.org/urn:doi:10.1186/s12876-019-0985-1
url https://ddd.uab.cat/record/286565
https://dx.doi.org/urn:doi:10.1186/s12876-019-0985-1
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
https://creativecommons.org/licenses/by/4.0/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
https://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:Dipòsit Digital de Documents de la UAB
instname:Universitat Autònoma de Barcelona
instname_str Universitat Autònoma de Barcelona
reponame_str Dipòsit Digital de Documents de la UAB
collection Dipòsit Digital de Documents de la UAB
repository.name.fl_str_mv
repository.mail.fl_str_mv
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