Increased Disease Burden in Irritable Bowel Syndrome With Comorbid Conditions and Psychiatric Diagnoses in a Multinational European Cohort

Patients with Irritable bowel syndrome (IBS) frequently suffer from comorbid psychiatric or somatic conditions, but the association with overall GI symptom severity and disease burden in IBS has not yet been established. This pan-European project, the DISCOvERIE project, aimed to characterize IBS pa...

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Detalles Bibliográficos
Autores: Midenfjord, Irina|||0000-0003-3168-1075, Khadija, Mahrukh, Sundelin, Elias|||0000-0001-6485-082X, Trindade, Inês A., Tornblom, Hans|||0000-0003-2117-9874, Santos, Javier|||0000-0002-4798-5033, Lobo Álvarez, Beatriz|||0000-0003-3391-7125, Mulder, Danique|||0000-0002-3927-4784, Vasquez, Alejandro Arias, Ruesing, Georgy, Reif, Andreas|||0000-0002-0992-634X, Aichholzer, Mareike|||0000-0002-1291-3304, Van Den Houte, Maaike, Van Oudenhove, Lukas|||0000-0002-6540-3113, Matteucci, Maria Chiara, Barbara, Giovanni|||0000-0001-9745-0726, Bosman, Michelle|||0000-0002-2040-2520, Jonkers, Daisy, Ramos-Quiroga, Josep Antoni|||0000-0003-1622-0350, Jekkel, Eva, Bitter, István|||0000-0002-9464-4709, Pop, Andrei-Vasile, Dumitrascu, Dan Lucian, Alonso Cotoner, Carmen|||0000-0002-3483-2919, Rodríguez-Urrutia, Amanda|||0000-0001-6882-205X, Simrén, Magnus
Tipo de recurso: artículo
Fecha de publicación:2025
País:España
Institución:Universitat Autònoma de Barcelona
Repositorio:Dipòsit Digital de Documents de la UAB
Idioma:inglés
OAI Identifier:oai:ddd.uab.cat:326294
Acceso en línea:https://ddd.uab.cat/record/326294
https://dx.doi.org/urn:doi:10.1002/ueg2.70157
Access Level:acceso abierto
Palabra clave:Anxiety
Chronic fatigue syndrome
Depression
Fibromyalgia
Gastrointestinal symptoms
IBS
Irritable bowel syndrome
Psychiatric diagnoses
Symptom burden
Symptom severity
Descripción
Sumario:Patients with Irritable bowel syndrome (IBS) frequently suffer from comorbid psychiatric or somatic conditions, but the association with overall GI symptom severity and disease burden in IBS has not yet been established. This pan-European project, the DISCOvERIE project, aimed to characterize IBS patients with and without comorbid psychiatric (anxiety, depression) and/or somatic (fibromyalgia, chronic fatigue syndrome) conditions, and to compare them with disease (psychiatric and/or somatic condition without IBS) and healthy controls to further elucidate the effect of comorbid conditions on the disease burden in IBS. Participants from nine different European centers were included: IBS patients (Rome IV criteria) with and without comorbid conditions, disease controls, and healthy controls. The presence of comorbidities was assessed through the Mini International Neuropsychiatric Interview (MINI) for anxiety or depression or through diagnostic criteria for fibromyalgia or chronic fatigue syndrome. Validated questionnaires on IBS (IBS-SSS), depressive (PHQ-9), anxiety (GAD-7) and somatic symptom severity (PHQ-12), fibromyalgia symptoms (FIQ) and fatigue (MFI) were completed. In total, 842 participants were recruited between March 2021 and January 2023, of which 607 had IBS, 161 were disease controls and 74 were healthy controls. IBS, anxiety, depression, somatic symptoms and fatigue were more severe in IBS patients with comorbidities compared with IBS patients without comorbidities. The severity of the abovementioned symptoms all increased gradually with increasing number of comorbidities (all p.

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