The Lorentz force on ions in membrane channels of neurons as a mechanism for transcranial static magnetic stimulation

Transcranial static magnetic stimulation is a novel noninvasive method of reduction of the cortical excitability in certain neurological diseases that makes use of static magnetic fields generated by permanent magnets. By contrast, ordinary transcranial magnetic stimulation makes use of pulsed magne...

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Authors: Freire Rosales, Manuel José, Bernal Méndez, Joaquín, Pérez Izquierdo, Alberto Tomás
Format: article
Status:Versión aceptada para publicación
Publication Date:2020
Country:España
Institution:Universidad de Sevilla (US)
Repository:idUS. Depósito de Investigación de la Universidad de Sevilla
OAI Identifier:oai:idus.us.es:11441/147985
Online Access:https://hdl.handle.net/11441/147985
https://doi.org/10.1080/15368378.2020.1793172
Access Level:Open access
Keyword:Brain stimulation
Transcranial static magnetic stimulation
Static magnetic field
Transcranial Static Magnetic Stimulation
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spelling The Lorentz force on ions in membrane channels of neurons as a mechanism for transcranial static magnetic stimulationFreire Rosales, Manuel JoséBernal Méndez, JoaquínPérez Izquierdo, Alberto TomásBrain stimulationTranscranial static magnetic stimulationStatic magnetic fieldTranscranial Static Magnetic StimulationTranscranial static magnetic stimulation is a novel noninvasive method of reduction of the cortical excitability in certain neurological diseases that makes use of static magnetic fields generated by permanent magnets. By contrast, ordinary transcranial magnetic stimulation makes use of pulsed magnetic fields generated by strong currents. Whereas the physical principle underlying ordinary transcranial magnetic stimulation is well known, that is, the Faraday´s law, the physical mechanism that explains the interaction between neurons and static magnetic fields in transcranial static magnetic stimulation remains unclear. In the present work, it is discussed the possibility that this mechanism might be the Lorentz force exerted on the ions flowing along the membrane channels of neurons. The overall effect of the static magnetic field would be to introduce an additional friction between the ions and the walls of the membrane channels, thus reducing its conductance. Calculations performed by using a Hodgkin–Huxley model demonstrate that even a slight reduction of the conductance of the membrane channels can lead to the suppression of the action potential, thus inhibiting neuronal activity.Taylor & FrancisFísica Aplicada IIIElectrónica y Electromagnetismo2020info:eu-repo/semantics/articleinfo:eu-repo/semantics/acceptedVersionapplication/pdfapplication/pdfhttps://hdl.handle.net/11441/147985https://doi.org/10.1080/15368378.2020.1793172reponame:idUS. Depósito de Investigación de la Universidad de Sevillainstname:Universidad de Sevilla (US)InglésElectromagnetic Biology and Medicine, 39 (4), 310-315.https://www.tandfonline.com/doi/abs/10.1080/15368378.2020.1793172?journalCode=iebm20info:eu-repo/semantics/openAccessoai:idus.us.es:11441/1479852026-06-17T12:51:07Z
dc.title.none.fl_str_mv The Lorentz force on ions in membrane channels of neurons as a mechanism for transcranial static magnetic stimulation
title The Lorentz force on ions in membrane channels of neurons as a mechanism for transcranial static magnetic stimulation
spellingShingle The Lorentz force on ions in membrane channels of neurons as a mechanism for transcranial static magnetic stimulation
Freire Rosales, Manuel José
Brain stimulation
Transcranial static magnetic stimulation
Static magnetic field
Transcranial Static Magnetic Stimulation
title_short The Lorentz force on ions in membrane channels of neurons as a mechanism for transcranial static magnetic stimulation
title_full The Lorentz force on ions in membrane channels of neurons as a mechanism for transcranial static magnetic stimulation
title_fullStr The Lorentz force on ions in membrane channels of neurons as a mechanism for transcranial static magnetic stimulation
title_full_unstemmed The Lorentz force on ions in membrane channels of neurons as a mechanism for transcranial static magnetic stimulation
title_sort The Lorentz force on ions in membrane channels of neurons as a mechanism for transcranial static magnetic stimulation
dc.creator.none.fl_str_mv Freire Rosales, Manuel José
Bernal Méndez, Joaquín
Pérez Izquierdo, Alberto Tomás
author Freire Rosales, Manuel José
author_facet Freire Rosales, Manuel José
Bernal Méndez, Joaquín
Pérez Izquierdo, Alberto Tomás
author_role author
author2 Bernal Méndez, Joaquín
Pérez Izquierdo, Alberto Tomás
author2_role author
author
dc.contributor.none.fl_str_mv Física Aplicada III
Electrónica y Electromagnetismo
dc.subject.none.fl_str_mv Brain stimulation
Transcranial static magnetic stimulation
Static magnetic field
Transcranial Static Magnetic Stimulation
topic Brain stimulation
Transcranial static magnetic stimulation
Static magnetic field
Transcranial Static Magnetic Stimulation
description Transcranial static magnetic stimulation is a novel noninvasive method of reduction of the cortical excitability in certain neurological diseases that makes use of static magnetic fields generated by permanent magnets. By contrast, ordinary transcranial magnetic stimulation makes use of pulsed magnetic fields generated by strong currents. Whereas the physical principle underlying ordinary transcranial magnetic stimulation is well known, that is, the Faraday´s law, the physical mechanism that explains the interaction between neurons and static magnetic fields in transcranial static magnetic stimulation remains unclear. In the present work, it is discussed the possibility that this mechanism might be the Lorentz force exerted on the ions flowing along the membrane channels of neurons. The overall effect of the static magnetic field would be to introduce an additional friction between the ions and the walls of the membrane channels, thus reducing its conductance. Calculations performed by using a Hodgkin–Huxley model demonstrate that even a slight reduction of the conductance of the membrane channels can lead to the suppression of the action potential, thus inhibiting neuronal activity.
publishDate 2020
dc.date.none.fl_str_mv 2020
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/acceptedVersion
format article
status_str acceptedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/11441/147985
https://doi.org/10.1080/15368378.2020.1793172
url https://hdl.handle.net/11441/147985
https://doi.org/10.1080/15368378.2020.1793172
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Electromagnetic Biology and Medicine, 39 (4), 310-315.
https://www.tandfonline.com/doi/abs/10.1080/15368378.2020.1793172?journalCode=iebm20
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Taylor & Francis
publisher.none.fl_str_mv Taylor & Francis
dc.source.none.fl_str_mv reponame:idUS. Depósito de Investigación de la Universidad de Sevilla
instname:Universidad de Sevilla (US)
instname_str Universidad de Sevilla (US)
reponame_str idUS. Depósito de Investigación de la Universidad de Sevilla
collection idUS. Depósito de Investigación de la Universidad de Sevilla
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,300724

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