Cytokine and antibody responses to Plasmodium falciparum in naïve individuals during a first malaria episode: effect of age and malaria exposure.
Age- and exposure-dependent immune responses during a malaria episode may be key to understanding the role of these factors in the acquisition of immunity to malaria. Plasma/serum samples collected from naïve Mozambican children (n = 48), European adults (naïve travelers, n = 22; expatriates with fe...
| Autores: | , , , , , , , , , , , , , , , , , |
|---|---|
| Formato: | artículo |
| Estado: | Versión publicada |
| Fecha de publicación: | 2013 |
| País: | España |
| Recursos: | Universidad de Barcelona |
| Repositorio: | Dipòsit Digital de la UB |
| OAI Identifier: | oai:diposit.ub.edu:2445/121775 |
| Acesso em linha: | https://hdl.handle.net/2445/121775 |
| Access Level: | acceso abierto |
| Palavra-chave: | Citoquines Malària Plasmodium falciparum Cytokines Malaria |
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Cytokine and antibody responses to Plasmodium falciparum in naïve individuals during a first malaria episode: effect of age and malaria exposure.Moncunill Piñas, GemmaMayor Aparicio, Alfredo GabrielJiménez, AlfonsNhabomba, Augusto J.Puyol, LauraManaca, Maria NéliaBarrios, DianaCisteró, PauGuinovart, CaterinaAguilar, RuthBardají, AzucenaPinazo, Maria-JesusAngov, EvelinaDutta, SheetijChitnis, Chetan E.Muñoz, JoséGascón i Brustenga, JoaquimDobaño, Carlota, 1969-CitoquinesMalàriaPlasmodium falciparumCytokinesMalariaPlasmodium falciparumAge- and exposure-dependent immune responses during a malaria episode may be key to understanding the role of these factors in the acquisition of immunity to malaria. Plasma/serum samples collected from naïve Mozambican children (n = 48), European adults (naïve travelers, n = 22; expatriates with few prior malaria exposures, n = 15) and Mozambican adults with long-life malaria exposure (n = 99) during and after a malaria episode were analyzed for IgG against merozoite proteins by Luminex and against infected erythrocytes by flow cytometry. Cytokines and chemokines were analyzed in plasmas/sera by suspension array technology. No differences were detected between children and adults with a primary infection, with the exception of higher IgG levels against 3D7 MSP-142 (P = 0.030) and a P. falciparum isolate (P = 0.002), as well as higher IL-12 (P = 0.020) in children compared to other groups. Compared to malaria-exposed adults, children, travelers and expatriates had higher concentrations of IFN-γ (P≤0.0090), IL-2 (P≤0.0379) and IL-8 (P≤0.0233). Children also had higher IL-12 (P = 0.0001), IL-4 (P = 0.003), IL-1β (P = 0.024) and TNF (P = 0.006) levels compared to malaria-exposed adults. Although IL-12 was elevated in children, overall the data do not support a role of age in immune responses to a first malaria episode. A TH1/pro-inflammatory response was the hallmark of non-immune subjects.Public Library of Science (PLoS)2013info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://hdl.handle.net/2445/121775Articles publicats en revistes (Medicina)reponame:Dipòsit Digital de la UBinstname:Universidad de BarcelonaInglésReproducció del document publicat a: https://doi.org/10.1371/journal.pone.0055756PLoS One, 2013https://doi.org/10.1371/journal.pone.0055756cc-by (c) Moncunill, Gemma et al., 2013http://creativecommons.org/licenses/by/3.0/esinfo:eu-repo/semantics/openAccessoai:diposit.ub.edu:2445/1217752026-05-27T06:46:51Z |
| dc.title.none.fl_str_mv |
Cytokine and antibody responses to Plasmodium falciparum in naïve individuals during a first malaria episode: effect of age and malaria exposure. |
| title |
Cytokine and antibody responses to Plasmodium falciparum in naïve individuals during a first malaria episode: effect of age and malaria exposure. |
| spellingShingle |
Cytokine and antibody responses to Plasmodium falciparum in naïve individuals during a first malaria episode: effect of age and malaria exposure. Moncunill Piñas, Gemma Citoquines Malària Plasmodium falciparum Cytokines Malaria Plasmodium falciparum |
| title_short |
Cytokine and antibody responses to Plasmodium falciparum in naïve individuals during a first malaria episode: effect of age and malaria exposure. |
| title_full |
Cytokine and antibody responses to Plasmodium falciparum in naïve individuals during a first malaria episode: effect of age and malaria exposure. |
| title_fullStr |
Cytokine and antibody responses to Plasmodium falciparum in naïve individuals during a first malaria episode: effect of age and malaria exposure. |
| title_full_unstemmed |
Cytokine and antibody responses to Plasmodium falciparum in naïve individuals during a first malaria episode: effect of age and malaria exposure. |
| title_sort |
Cytokine and antibody responses to Plasmodium falciparum in naïve individuals during a first malaria episode: effect of age and malaria exposure. |
| dc.creator.none.fl_str_mv |
Moncunill Piñas, Gemma Mayor Aparicio, Alfredo Gabriel Jiménez, Alfons Nhabomba, Augusto J. Puyol, Laura Manaca, Maria Nélia Barrios, Diana Cisteró, Pau Guinovart, Caterina Aguilar, Ruth Bardají, Azucena Pinazo, Maria-Jesus Angov, Evelina Dutta, Sheetij Chitnis, Chetan E. Muñoz, José Gascón i Brustenga, Joaquim Dobaño, Carlota, 1969- |
| author |
Moncunill Piñas, Gemma |
| author_facet |
Moncunill Piñas, Gemma Mayor Aparicio, Alfredo Gabriel Jiménez, Alfons Nhabomba, Augusto J. Puyol, Laura Manaca, Maria Nélia Barrios, Diana Cisteró, Pau Guinovart, Caterina Aguilar, Ruth Bardají, Azucena Pinazo, Maria-Jesus Angov, Evelina Dutta, Sheetij Chitnis, Chetan E. Muñoz, José Gascón i Brustenga, Joaquim Dobaño, Carlota, 1969- |
| author_role |
author |
| author2 |
Mayor Aparicio, Alfredo Gabriel Jiménez, Alfons Nhabomba, Augusto J. Puyol, Laura Manaca, Maria Nélia Barrios, Diana Cisteró, Pau Guinovart, Caterina Aguilar, Ruth Bardají, Azucena Pinazo, Maria-Jesus Angov, Evelina Dutta, Sheetij Chitnis, Chetan E. Muñoz, José Gascón i Brustenga, Joaquim Dobaño, Carlota, 1969- |
| author2_role |
author author author author author author author author author author author author author author author author author |
| dc.subject.none.fl_str_mv |
Citoquines Malària Plasmodium falciparum Cytokines Malaria Plasmodium falciparum |
| topic |
Citoquines Malària Plasmodium falciparum Cytokines Malaria Plasmodium falciparum |
| description |
Age- and exposure-dependent immune responses during a malaria episode may be key to understanding the role of these factors in the acquisition of immunity to malaria. Plasma/serum samples collected from naïve Mozambican children (n = 48), European adults (naïve travelers, n = 22; expatriates with few prior malaria exposures, n = 15) and Mozambican adults with long-life malaria exposure (n = 99) during and after a malaria episode were analyzed for IgG against merozoite proteins by Luminex and against infected erythrocytes by flow cytometry. Cytokines and chemokines were analyzed in plasmas/sera by suspension array technology. No differences were detected between children and adults with a primary infection, with the exception of higher IgG levels against 3D7 MSP-142 (P = 0.030) and a P. falciparum isolate (P = 0.002), as well as higher IL-12 (P = 0.020) in children compared to other groups. Compared to malaria-exposed adults, children, travelers and expatriates had higher concentrations of IFN-γ (P≤0.0090), IL-2 (P≤0.0379) and IL-8 (P≤0.0233). Children also had higher IL-12 (P = 0.0001), IL-4 (P = 0.003), IL-1β (P = 0.024) and TNF (P = 0.006) levels compared to malaria-exposed adults. Although IL-12 was elevated in children, overall the data do not support a role of age in immune responses to a first malaria episode. A TH1/pro-inflammatory response was the hallmark of non-immune subjects. |
| publishDate |
2013 |
| dc.date.none.fl_str_mv |
2013 |
| dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
| format |
article |
| status_str |
publishedVersion |
| dc.identifier.none.fl_str_mv |
https://hdl.handle.net/2445/121775 |
| url |
https://hdl.handle.net/2445/121775 |
| dc.language.none.fl_str_mv |
Inglés |
| language_invalid_str_mv |
Inglés |
| dc.relation.none.fl_str_mv |
Reproducció del document publicat a: https://doi.org/10.1371/journal.pone.0055756 PLoS One, 2013 https://doi.org/10.1371/journal.pone.0055756 |
| dc.rights.none.fl_str_mv |
cc-by (c) Moncunill, Gemma et al., 2013 http://creativecommons.org/licenses/by/3.0/es info:eu-repo/semantics/openAccess |
| rights_invalid_str_mv |
cc-by (c) Moncunill, Gemma et al., 2013 http://creativecommons.org/licenses/by/3.0/es |
| eu_rights_str_mv |
openAccess |
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application/pdf |
| dc.publisher.none.fl_str_mv |
Public Library of Science (PLoS) |
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Public Library of Science (PLoS) |
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Articles publicats en revistes (Medicina) reponame:Dipòsit Digital de la UB instname:Universidad de Barcelona |
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Universidad de Barcelona |
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Dipòsit Digital de la UB |
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Dipòsit Digital de la UB |
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15.301603 |