Cytokine and antibody responses to Plasmodium falciparum in naïve individuals during a first malaria episode: effect of age and malaria exposure.

Age- and exposure-dependent immune responses during a malaria episode may be key to understanding the role of these factors in the acquisition of immunity to malaria. Plasma/serum samples collected from naïve Mozambican children (n = 48), European adults (naïve travelers, n = 22; expatriates with fe...

Descripción completa

Detalles Bibliográficos
Autores: Moncunill Piñas, Gemma, Mayor Aparicio, Alfredo Gabriel, Jiménez, Alfons, Nhabomba, Augusto J., Puyol, Laura, Manaca, Maria Nélia, Barrios, Diana, Cisteró, Pau, Guinovart, Caterina, Aguilar, Ruth, Bardají, Azucena, Pinazo, Maria-Jesus, Angov, Evelina, Dutta, Sheetij, Chitnis, Chetan E., Muñoz, José, Gascón i Brustenga, Joaquim, Dobaño, Carlota, 1969-
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2013
País:España
Institución:Universidad de Barcelona
Repositorio:Dipòsit Digital de la UB
OAI Identifier:oai:diposit.ub.edu:2445/121775
Acceso en línea:https://hdl.handle.net/2445/121775
Access Level:acceso abierto
Palabra clave:Citoquines
Malària
Plasmodium falciparum
Cytokines
Malaria
Descripción
Sumario:Age- and exposure-dependent immune responses during a malaria episode may be key to understanding the role of these factors in the acquisition of immunity to malaria. Plasma/serum samples collected from naïve Mozambican children (n = 48), European adults (naïve travelers, n = 22; expatriates with few prior malaria exposures, n = 15) and Mozambican adults with long-life malaria exposure (n = 99) during and after a malaria episode were analyzed for IgG against merozoite proteins by Luminex and against infected erythrocytes by flow cytometry. Cytokines and chemokines were analyzed in plasmas/sera by suspension array technology. No differences were detected between children and adults with a primary infection, with the exception of higher IgG levels against 3D7 MSP-142 (P = 0.030) and a P. falciparum isolate (P = 0.002), as well as higher IL-12 (P = 0.020) in children compared to other groups. Compared to malaria-exposed adults, children, travelers and expatriates had higher concentrations of IFN-γ (P≤0.0090), IL-2 (P≤0.0379) and IL-8 (P≤0.0233). Children also had higher IL-12 (P = 0.0001), IL-4 (P = 0.003), IL-1β (P = 0.024) and TNF (P = 0.006) levels compared to malaria-exposed adults. Although IL-12 was elevated in children, overall the data do not support a role of age in immune responses to a first malaria episode. A TH1/pro-inflammatory response was the hallmark of non-immune subjects.

Similares en LA Referencia