Coexistence of immune-mediated diseases in sarcoidosis. Frequency and clinical significance in 1737 patients
Objective: To analyze whether immune-mediated diseases (IMDs) occurs in sarcoidosis more commonly than expected in the general population, and how concomitant IMDs influence the clinical presentation of the disease. Methods: We searched for coexisting IMDs in patients included in the SARCOGEAS-cohor...
| Autores: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
|---|---|
| Tipo de recurso: | artículo |
| Fecha de publicación: | 2021 |
| País: | España |
| Institución: | Conselleria de Salut i Consum del Govern de les Illes Balears |
| Repositorio: | Docusalut |
| Idioma: | inglés |
| OAI Identifier: | oai:docusalut.com:20.500.13003/19505 |
| Acceso en línea: | https://hdl.handle.net/20.500.13003/19505 |
| Access Level: | acceso abierto |
| Palabra clave: | Autoimmune Diseases Male Sarcoidosis Female Humans Odds Ratio Cohort Studies Estudios de Cohortes Humanos Oportunidad Relativa Femenino Enfermedades Autoinmunes Masculino Autoimmune diseases Immunodeficiencies Sjogren syndrome Systemic sclerosis Antiphospholipid syndrome Primary biliary cholangitis Autoimmune hepatitis Cytopenias Arthritis |
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Coexistence of immune-mediated diseases in sarcoidosis. Frequency and clinical significance in 1737 patientsBrito-Zeron, PilarPerez-Alvarez, RobertoFeijoo-Masso, CarlosGracia-Tello, BorjaGonzalez-Garcia, AndresGomez-de-la-Torre, RicardoAlguacil, AnaLopez-Dupla, MiguelRobles, AngelGarcia-Morillo, SalvadorBonet, MarionaCruz-Caparros, GraciaFonseca-Aizpuru, EvaAkasbi, MiriamCallejas, Jose Luisde Miguel-Campo, BorjaPerez-de-Lis, MartaRamos-Casals, ManuelDe Escalante Yanguela, BegonaChara-Cervantes, JoelPerez-Conesa, M.Rascon, Francisco-JavierPallaresPerez-Guerrero, P.De la Red Bellvis, GloriaCalvo, E.Soler, CarlaPeral-Gutierrez, E.Gomez-Cerezo, J. F.Rodriguez-Fernandez, S.Pinilla, B.Toledo-Samaniego, N.Gato, A.Chamorro, Antonio J.Morcillo, C.Ojeda, I.Vives, M. J.de Miguel, BorjaPenades, M.De-Vicente, M.The SarcoGEAS-SEMI RegistryAutoimmune DiseasesMaleSarcoidosisFemaleHumansOdds RatioCohort StudiesEstudios de CohortesSarcoidosisHumanosOportunidad RelativaFemeninoEnfermedades AutoinmunesMasculinoSarcoidosisAutoimmune diseasesImmunodeficienciesSjogren syndromeSystemic sclerosisAntiphospholipid syndromePrimary biliary cholangitisAutoimmune hepatitisCytopeniasArthritisObjective: To analyze whether immune-mediated diseases (IMDs) occurs in sarcoidosis more commonly than expected in the general population, and how concomitant IMDs influence the clinical presentation of the disease. Methods: We searched for coexisting IMDs in patients included in the SARCOGEAS-cohort, a multicenter nationwide database of consecutive patients diagnosed according to the ATS/ESC/WASOG criteria. Comparisons were made considering the presence or absence of IMD clustering, and odds ratios (OR) and their 95% confidence intervals (CI) were calculated as the ratio of observed cases of every IMD in the sarcoidosis cohort to the observed cases in the general population. Results: Among 1737 patients with sarcoidosis, 283 (16%) patients presented at least one associated IMD. These patients were more commonly female (OR: 1.98, 95% CI: 1.49-2.62) and were diagnosed with sarcoidosis at an older age (49.6 vs. 47.5 years, P < 0.05). The frequency of IMDs in patients with sarcoidosis was nearly 2-fold higher than the frequency observed in the general population (OR: 1.64, 95% CI: 1.44-1.86). Significant associations were identified in 17 individual IMDs. In comparison with the general population, the IMDs with the strongest strength of association with sarcoidosis (OR > 5) were common variable immunodeficiency (CVID) (OR: 431.8), familial Mediterranean fever (OR 33.9), primary biliary cholangitis (OR: 16.57), haemolytic anemia (OR: 12.17), autoimmune hepatitis (OR: 9.01), antiphospholipid syndrome (OR: 8.70), immune thrombocytopenia (OR: 8.43), Sjogren syndrome (OR: 6.98), systemic sclerosis (OR: 5.71), ankylosing spondylitis (OR: 5.49), IgA deficiency (OR: 5.07) and psoriatic arthritis (OR: 5.06). Sex-adjusted ORs were considerably higher than crude ORs for eosinophilic digestive disease in women, and for immune thrombocytopenia, systemic sclerosis and autoimmune hepatitis in men Conclusion: We found coexisting IMDs in 1 out of 6 patients with sarcoidosis. The strongest associations were found for immunodeficiencies and some systemic, rheumatic, hepatic and hematological autoimmune diseases. (C) 2021 Published by Elsevier Masson SAS on behalf of Societe francaise de rhumatologie.Elsevier France-Editions Scientifiques Medicales Elsevier20212021-12-0120212021-12-01research articlehttp://purl.org/coar/resource_type/c_2df8fbb1info:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/20.500.13003/19505reponame:Docusalutinstname:Conselleria de Salut i Consum del Govern de les Illes BalearsInglésengopen accesshttp://purl.org/coar/access_right/c_abf2Attribution 4.0 Internationalhttp://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:docusalut.com:20.500.13003/195052026-06-22T12:44:07Z |
| dc.title.none.fl_str_mv |
Coexistence of immune-mediated diseases in sarcoidosis. Frequency and clinical significance in 1737 patients |
| title |
Coexistence of immune-mediated diseases in sarcoidosis. Frequency and clinical significance in 1737 patients |
| spellingShingle |
Coexistence of immune-mediated diseases in sarcoidosis. Frequency and clinical significance in 1737 patients Brito-Zeron, Pilar Autoimmune Diseases Male Sarcoidosis Female Humans Odds Ratio Cohort Studies Estudios de Cohortes Sarcoidosis Humanos Oportunidad Relativa Femenino Enfermedades Autoinmunes Masculino Sarcoidosis Autoimmune diseases Immunodeficiencies Sjogren syndrome Systemic sclerosis Antiphospholipid syndrome Primary biliary cholangitis Autoimmune hepatitis Cytopenias Arthritis |
| title_short |
Coexistence of immune-mediated diseases in sarcoidosis. Frequency and clinical significance in 1737 patients |
| title_full |
Coexistence of immune-mediated diseases in sarcoidosis. Frequency and clinical significance in 1737 patients |
| title_fullStr |
Coexistence of immune-mediated diseases in sarcoidosis. Frequency and clinical significance in 1737 patients |
| title_full_unstemmed |
Coexistence of immune-mediated diseases in sarcoidosis. Frequency and clinical significance in 1737 patients |
| title_sort |
Coexistence of immune-mediated diseases in sarcoidosis. Frequency and clinical significance in 1737 patients |
| dc.creator.none.fl_str_mv |
Brito-Zeron, Pilar Perez-Alvarez, Roberto Feijoo-Masso, Carlos Gracia-Tello, Borja Gonzalez-Garcia, Andres Gomez-de-la-Torre, Ricardo Alguacil, Ana Lopez-Dupla, Miguel Robles, Angel Garcia-Morillo, Salvador Bonet, Mariona Cruz-Caparros, Gracia Fonseca-Aizpuru, Eva Akasbi, Miriam Callejas, Jose Luis de Miguel-Campo, Borja Perez-de-Lis, Marta Ramos-Casals, Manuel De Escalante Yanguela, Begona Chara-Cervantes, Joel Perez-Conesa, M. Rascon, Francisco-Javier Pallares Perez-Guerrero, P. De la Red Bellvis, Gloria Calvo, E. Soler, Carla Peral-Gutierrez, E. Gomez-Cerezo, J. F. Rodriguez-Fernandez, S. Pinilla, B. Toledo-Samaniego, N. Gato, A. Chamorro, Antonio J. Morcillo, C. Ojeda, I. Vives, M. J. de Miguel, Borja Penades, M. De-Vicente, M. The SarcoGEAS-SEMI Registry |
| author |
Brito-Zeron, Pilar |
| author_facet |
Brito-Zeron, Pilar Perez-Alvarez, Roberto Feijoo-Masso, Carlos Gracia-Tello, Borja Gonzalez-Garcia, Andres Gomez-de-la-Torre, Ricardo Alguacil, Ana Lopez-Dupla, Miguel Robles, Angel Garcia-Morillo, Salvador Bonet, Mariona Cruz-Caparros, Gracia Fonseca-Aizpuru, Eva Akasbi, Miriam Callejas, Jose Luis de Miguel-Campo, Borja Perez-de-Lis, Marta Ramos-Casals, Manuel De Escalante Yanguela, Begona Chara-Cervantes, Joel Perez-Conesa, M. Rascon, Francisco-Javier Pallares Perez-Guerrero, P. De la Red Bellvis, Gloria Calvo, E. Soler, Carla Peral-Gutierrez, E. Gomez-Cerezo, J. F. Rodriguez-Fernandez, S. Pinilla, B. Toledo-Samaniego, N. Gato, A. Chamorro, Antonio J. Morcillo, C. Ojeda, I. Vives, M. J. de Miguel, Borja Penades, M. De-Vicente, M. The SarcoGEAS-SEMI Registry |
| author_role |
author |
| author2 |
Perez-Alvarez, Roberto Feijoo-Masso, Carlos Gracia-Tello, Borja Gonzalez-Garcia, Andres Gomez-de-la-Torre, Ricardo Alguacil, Ana Lopez-Dupla, Miguel Robles, Angel Garcia-Morillo, Salvador Bonet, Mariona Cruz-Caparros, Gracia Fonseca-Aizpuru, Eva Akasbi, Miriam Callejas, Jose Luis de Miguel-Campo, Borja Perez-de-Lis, Marta Ramos-Casals, Manuel De Escalante Yanguela, Begona Chara-Cervantes, Joel Perez-Conesa, M. Rascon, Francisco-Javier Pallares Perez-Guerrero, P. De la Red Bellvis, Gloria Calvo, E. Soler, Carla Peral-Gutierrez, E. Gomez-Cerezo, J. F. Rodriguez-Fernandez, S. Pinilla, B. Toledo-Samaniego, N. Gato, A. Chamorro, Antonio J. Morcillo, C. Ojeda, I. Vives, M. J. de Miguel, Borja Penades, M. De-Vicente, M. The SarcoGEAS-SEMI Registry |
| author2_role |
author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author |
| dc.contributor.none.fl_str_mv |
|
| dc.subject.none.fl_str_mv |
Autoimmune Diseases Male Sarcoidosis Female Humans Odds Ratio Cohort Studies Estudios de Cohortes Sarcoidosis Humanos Oportunidad Relativa Femenino Enfermedades Autoinmunes Masculino Sarcoidosis Autoimmune diseases Immunodeficiencies Sjogren syndrome Systemic sclerosis Antiphospholipid syndrome Primary biliary cholangitis Autoimmune hepatitis Cytopenias Arthritis |
| topic |
Autoimmune Diseases Male Sarcoidosis Female Humans Odds Ratio Cohort Studies Estudios de Cohortes Sarcoidosis Humanos Oportunidad Relativa Femenino Enfermedades Autoinmunes Masculino Sarcoidosis Autoimmune diseases Immunodeficiencies Sjogren syndrome Systemic sclerosis Antiphospholipid syndrome Primary biliary cholangitis Autoimmune hepatitis Cytopenias Arthritis |
| description |
Objective: To analyze whether immune-mediated diseases (IMDs) occurs in sarcoidosis more commonly than expected in the general population, and how concomitant IMDs influence the clinical presentation of the disease. Methods: We searched for coexisting IMDs in patients included in the SARCOGEAS-cohort, a multicenter nationwide database of consecutive patients diagnosed according to the ATS/ESC/WASOG criteria. Comparisons were made considering the presence or absence of IMD clustering, and odds ratios (OR) and their 95% confidence intervals (CI) were calculated as the ratio of observed cases of every IMD in the sarcoidosis cohort to the observed cases in the general population. Results: Among 1737 patients with sarcoidosis, 283 (16%) patients presented at least one associated IMD. These patients were more commonly female (OR: 1.98, 95% CI: 1.49-2.62) and were diagnosed with sarcoidosis at an older age (49.6 vs. 47.5 years, P < 0.05). The frequency of IMDs in patients with sarcoidosis was nearly 2-fold higher than the frequency observed in the general population (OR: 1.64, 95% CI: 1.44-1.86). Significant associations were identified in 17 individual IMDs. In comparison with the general population, the IMDs with the strongest strength of association with sarcoidosis (OR > 5) were common variable immunodeficiency (CVID) (OR: 431.8), familial Mediterranean fever (OR 33.9), primary biliary cholangitis (OR: 16.57), haemolytic anemia (OR: 12.17), autoimmune hepatitis (OR: 9.01), antiphospholipid syndrome (OR: 8.70), immune thrombocytopenia (OR: 8.43), Sjogren syndrome (OR: 6.98), systemic sclerosis (OR: 5.71), ankylosing spondylitis (OR: 5.49), IgA deficiency (OR: 5.07) and psoriatic arthritis (OR: 5.06). Sex-adjusted ORs were considerably higher than crude ORs for eosinophilic digestive disease in women, and for immune thrombocytopenia, systemic sclerosis and autoimmune hepatitis in men Conclusion: We found coexisting IMDs in 1 out of 6 patients with sarcoidosis. The strongest associations were found for immunodeficiencies and some systemic, rheumatic, hepatic and hematological autoimmune diseases. (C) 2021 Published by Elsevier Masson SAS on behalf of Societe francaise de rhumatologie. |
| publishDate |
2021 |
| dc.date.none.fl_str_mv |
2021 2021-12-01 2021 2021-12-01 |
| dc.type.none.fl_str_mv |
research article http://purl.org/coar/resource_type/c_2df8fbb1 |
| dc.type.openaire.fl_str_mv |
info:eu-repo/semantics/article |
| format |
article |
| dc.identifier.none.fl_str_mv |
https://hdl.handle.net/20.500.13003/19505 |
| url |
https://hdl.handle.net/20.500.13003/19505 |
| dc.language.none.fl_str_mv |
Inglés eng |
| language_invalid_str_mv |
Inglés |
| language |
eng |
| dc.rights.none.fl_str_mv |
open access http://purl.org/coar/access_right/c_abf2 Attribution 4.0 International http://creativecommons.org/licenses/by/4.0/ |
| dc.rights.openaire.fl_str_mv |
info:eu-repo/semantics/openAccess |
| rights_invalid_str_mv |
open access http://purl.org/coar/access_right/c_abf2 Attribution 4.0 International http://creativecommons.org/licenses/by/4.0/ |
| eu_rights_str_mv |
openAccess |
| dc.format.none.fl_str_mv |
application/pdf |
| dc.publisher.none.fl_str_mv |
Elsevier France-Editions Scientifiques Medicales Elsevier |
| publisher.none.fl_str_mv |
Elsevier France-Editions Scientifiques Medicales Elsevier |
| dc.source.none.fl_str_mv |
reponame:Docusalut instname:Conselleria de Salut i Consum del Govern de les Illes Balears |
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Conselleria de Salut i Consum del Govern de les Illes Balears |
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Docusalut |
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Docusalut |
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1869419622427525120 |
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15,811543 |