Coexistence of immune-mediated diseases in sarcoidosis. Frequency and clinical significance in 1737 patients

Objective: To analyze whether immune-mediated diseases (IMDs) occurs in sarcoidosis more commonly than expected in the general population, and how concomitant IMDs influence the clinical presentation of the disease. Methods: We searched for coexisting IMDs in patients included in the SARCOGEAS-cohor...

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Detalles Bibliográficos
Autores: Brito-Zeron, Pilar, Perez-Alvarez, Roberto, Feijoo-Masso, Carlos, Gracia-Tello, Borja, Gonzalez-Garcia, Andres, Gomez-de-la-Torre, Ricardo, Alguacil, Ana, Lopez-Dupla, Miguel, Robles, Angel, Garcia-Morillo, Salvador, Bonet, Mariona, Cruz-Caparros, Gracia, Fonseca-Aizpuru, Eva, Akasbi, Miriam, Callejas, Jose Luis, de Miguel-Campo, Borja, Perez-de-Lis, Marta, Ramos-Casals, Manuel, De Escalante Yanguela, Begona, Chara-Cervantes, Joel, Perez-Conesa, M., Rascon, Francisco-Javier, Pallares, Perez-Guerrero, P., De la Red Bellvis, Gloria, Calvo, E., Soler, Carla, Peral-Gutierrez, E., Gomez-Cerezo, J. F., Rodriguez-Fernandez, S., Pinilla, B., Toledo-Samaniego, N., Gato, A., Chamorro, Antonio J., Morcillo, C., Ojeda, I., Vives, M. J., de Miguel, Borja, Penades, M., De-Vicente, M., The SarcoGEAS-SEMI Registry
Tipo de recurso: artículo
Fecha de publicación:2021
País:España
Institución:Conselleria de Salut i Consum del Govern de les Illes Balears
Repositorio:Docusalut
Idioma:inglés
OAI Identifier:oai:docusalut.com:20.500.13003/19505
Acceso en línea:https://hdl.handle.net/20.500.13003/19505
Access Level:acceso abierto
Palabra clave:Autoimmune Diseases
Male
Sarcoidosis
Female
Humans
Odds Ratio
Cohort Studies
Estudios de Cohortes
Humanos
Oportunidad Relativa
Femenino
Enfermedades Autoinmunes
Masculino
Autoimmune diseases
Immunodeficiencies
Sjogren syndrome
Systemic sclerosis
Antiphospholipid syndrome
Primary biliary cholangitis
Autoimmune hepatitis
Cytopenias
Arthritis
Descripción
Sumario:Objective: To analyze whether immune-mediated diseases (IMDs) occurs in sarcoidosis more commonly than expected in the general population, and how concomitant IMDs influence the clinical presentation of the disease. Methods: We searched for coexisting IMDs in patients included in the SARCOGEAS-cohort, a multicenter nationwide database of consecutive patients diagnosed according to the ATS/ESC/WASOG criteria. Comparisons were made considering the presence or absence of IMD clustering, and odds ratios (OR) and their 95% confidence intervals (CI) were calculated as the ratio of observed cases of every IMD in the sarcoidosis cohort to the observed cases in the general population. Results: Among 1737 patients with sarcoidosis, 283 (16%) patients presented at least one associated IMD. These patients were more commonly female (OR: 1.98, 95% CI: 1.49-2.62) and were diagnosed with sarcoidosis at an older age (49.6 vs. 47.5 years, P < 0.05). The frequency of IMDs in patients with sarcoidosis was nearly 2-fold higher than the frequency observed in the general population (OR: 1.64, 95% CI: 1.44-1.86). Significant associations were identified in 17 individual IMDs. In comparison with the general population, the IMDs with the strongest strength of association with sarcoidosis (OR > 5) were common variable immunodeficiency (CVID) (OR: 431.8), familial Mediterranean fever (OR 33.9), primary biliary cholangitis (OR: 16.57), haemolytic anemia (OR: 12.17), autoimmune hepatitis (OR: 9.01), antiphospholipid syndrome (OR: 8.70), immune thrombocytopenia (OR: 8.43), Sjogren syndrome (OR: 6.98), systemic sclerosis (OR: 5.71), ankylosing spondylitis (OR: 5.49), IgA deficiency (OR: 5.07) and psoriatic arthritis (OR: 5.06). Sex-adjusted ORs were considerably higher than crude ORs for eosinophilic digestive disease in women, and for immune thrombocytopenia, systemic sclerosis and autoimmune hepatitis in men Conclusion: We found coexisting IMDs in 1 out of 6 patients with sarcoidosis. The strongest associations were found for immunodeficiencies and some systemic, rheumatic, hepatic and hematological autoimmune diseases. (C) 2021 Published by Elsevier Masson SAS on behalf of Societe francaise de rhumatologie.

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