The role of clonal communication and heterogeneity in breast cancer

[Background] Cancer is a rapidly evolving, multifactorial disease that accumulates numerous genetic and epigenetic alterations. This results in molecular and phenotypic heterogeneity within the tumor, the complexity of which is further amplified through specific interactions between cancer cells. We...

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Bibliographic Details
Authors: Martín-Pardillos, Ana, Valls Chiva, Ángeles, Bande Vargas, Gemma, Hurtado Blanco, Pablo, Piñeiro Cid, Roberto, Guijarro, Pedro J., Hümmer, Stefan, Bejar Serrano, Eva, Rodriguez-Casanova, Aitor, Díaz-Lagares, Ángel, Castellví, Josep, Miravet-Verde, Samuel, Serrano, Luis, Lluch-Senar, María, Sebastián, Víctor, Bribián, Ana, López-Mascaraque, Laura, López-López, Rafael, Ramón y Cajal, Santiago
Format: article
Publication Date:2019
Country:España
Institution:Consejo Superior de Investigaciones Científicas (CSIC)
Repository:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/185584
Online Access:http://hdl.handle.net/10261/185584
Access Level:Open access
Keyword:Tumor
Breast
Cancer
Metastasis
Heterogeneity
Clone
Communication
Cooperation
MDA-MB-231
Description
Summary:[Background] Cancer is a rapidly evolving, multifactorial disease that accumulates numerous genetic and epigenetic alterations. This results in molecular and phenotypic heterogeneity within the tumor, the complexity of which is further amplified through specific interactions between cancer cells. We aimed to dissect the molecular mechanisms underlying the cooperation between different clones.

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