The role of clonal communication and heterogeneity in breast cancer

[Background] Cancer is a rapidly evolving, multifactorial disease that accumulates numerous genetic and epigenetic alterations. This results in molecular and phenotypic heterogeneity within the tumor, the complexity of which is further amplified through specific interactions between cancer cells. We...

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Detalles Bibliográficos
Autores: Martín-Pardillos, Ana, Valls Chiva, Ángeles, Bande Vargas, Gemma, Hurtado Blanco, Pablo, Piñeiro Cid, Roberto, Guijarro, Pedro J., Hümmer, Stefan, Bejar Serrano, Eva, Rodriguez-Casanova, Aitor, Díaz-Lagares, Ángel, Castellví, Josep, Miravet-Verde, Samuel, Serrano, Luis, Lluch-Senar, María, Sebastián, Víctor, Bribián, Ana, López-Mascaraque, Laura, López-López, Rafael, Ramón y Cajal, Santiago
Tipo de recurso: artículo
Fecha de publicación:2019
País:España
Institución:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/185584
Acceso en línea:http://hdl.handle.net/10261/185584
Access Level:acceso abierto
Palabra clave:Tumor
Breast
Cancer
Metastasis
Heterogeneity
Clone
Communication
Cooperation
MDA-MB-231
Descripción
Sumario:[Background] Cancer is a rapidly evolving, multifactorial disease that accumulates numerous genetic and epigenetic alterations. This results in molecular and phenotypic heterogeneity within the tumor, the complexity of which is further amplified through specific interactions between cancer cells. We aimed to dissect the molecular mechanisms underlying the cooperation between different clones.

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