Effects of golimumab and ustekinumab on circulating dendritic cell migratory capacity in inflammatory bowel disease
Inflammatory bowel disease (IBD) is a chronic condition which includes ulcerative colitis (UC) and Crohn’s disease (CD), the origins of which are not yet fully understood. Both conditions involve an exacerbated immune response in the intestinal tract, leading to tissue inflammation. Dendritic cells...
| Autores: | , , , , , , , |
|---|---|
| Tipo de documento: | artigo |
| Data de publicação: | 2023 |
| País: | España |
| Recursos: | Universidad Autónoma de Madrid |
| Repositório: | Biblos-e Archivo. Repositorio Institucional de la UAM |
| Idioma: | inglês |
| OAI Identifier: | oai:repositorio.uam.es:10486/709409 |
| Acesso em linha: | http://hdl.handle.net/10486/709409 https://dx.doi.org/10.3390/biomedicines11102831 |
| Access Level: | Acceso aberto |
| Palavra-chave: | dendritic cell golimumab ustekinumab inflammatory bowel disease ulcerative colitis Crohn’s disease Medicina |
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Effects of golimumab and ustekinumab on circulating dendritic cell migratory capacity in inflammatory bowel diseaseSoleto, IreneRamírez, CristinaGómez, CristinaBaldan-Martin, MontseOrejudo, MacarenaMercado, JorgeChaparro Sánchez, MaríaPérez Gisbert, Francisco Javierdendritic cellgolimumabustekinumabinflammatory bowel diseaseulcerative colitisCrohn’s diseaseMedicinaInflammatory bowel disease (IBD) is a chronic condition which includes ulcerative colitis (UC) and Crohn’s disease (CD), the origins of which are not yet fully understood. Both conditions involve an exacerbated immune response in the intestinal tract, leading to tissue inflammation. Dendritic cells (DCs) are antigen-presenting cells crucial for maintaining tolerance in the gastrointestinal mucosa. Previous research has indicated that DC recruitment to the intestinal mucosa is more pronounced in individuals with IBD, but the specific mechanisms governing this migration remain unclear. This study aimed to assess the expression of various homing markers and the migratory abilities of circulating DC subsets in response to intestinal chemotactic signals. Additionally, this study examined how golimumab and ustekinumab impact these characteristics in individuals with IBD compared to healthy controls. The findings revealed that a particular subset of DCs known as type 2 conventional DCs (cDC2) displayed a more pronounced migratory profile compared to other DC subsets. Furthermore, the study observed that golimumab and ustekinumab had varying effects on the migratory profile of cDC1 in individuals with CD and UC. While CCL2 did not exert a chemoattractant effect on DC subsets in this patient cohort, treatment with golimumab and ustekinumab enhanced their migratory capacity towards CCL2 and CCL25 while reducing their migration towards MadCam1. In conclusion, this study highlights that cDC2 exhibits a heightened migratory profile towards the gastrointestinal mucosa compared to other DC subsets. This finding could be explored further for the development of new diagnostic biomarkers or the identification of potential immunomodulatory targets in the context of IBDMDPIDepartamento de MedicinaFacultad de Medicina20232023-10-18research articlehttp://purl.org/coar/resource_type/c_2df8fbb1VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10486/709409https://dx.doi.org/10.3390/biomedicines11102831reponame:Biblos-e Archivo. Repositorio Institucional de la UAMinstname:Universidad Autónoma de MadridInglésengopen accesshttp://purl.org/coar/access_right/c_abf2info:eu-repo/semantics/openAccessoai:repositorio.uam.es:10486/7094092026-06-23T12:46:27Z |
| dc.title.none.fl_str_mv |
Effects of golimumab and ustekinumab on circulating dendritic cell migratory capacity in inflammatory bowel disease |
| title |
Effects of golimumab and ustekinumab on circulating dendritic cell migratory capacity in inflammatory bowel disease |
| spellingShingle |
Effects of golimumab and ustekinumab on circulating dendritic cell migratory capacity in inflammatory bowel disease Soleto, Irene dendritic cell golimumab ustekinumab inflammatory bowel disease ulcerative colitis Crohn’s disease Medicina |
| title_short |
Effects of golimumab and ustekinumab on circulating dendritic cell migratory capacity in inflammatory bowel disease |
| title_full |
Effects of golimumab and ustekinumab on circulating dendritic cell migratory capacity in inflammatory bowel disease |
| title_fullStr |
Effects of golimumab and ustekinumab on circulating dendritic cell migratory capacity in inflammatory bowel disease |
| title_full_unstemmed |
Effects of golimumab and ustekinumab on circulating dendritic cell migratory capacity in inflammatory bowel disease |
| title_sort |
Effects of golimumab and ustekinumab on circulating dendritic cell migratory capacity in inflammatory bowel disease |
| dc.creator.none.fl_str_mv |
Soleto, Irene Ramírez, Cristina Gómez, Cristina Baldan-Martin, Montse Orejudo, Macarena Mercado, Jorge Chaparro Sánchez, María Pérez Gisbert, Francisco Javier |
| author |
Soleto, Irene |
| author_facet |
Soleto, Irene Ramírez, Cristina Gómez, Cristina Baldan-Martin, Montse Orejudo, Macarena Mercado, Jorge Chaparro Sánchez, María Pérez Gisbert, Francisco Javier |
| author_role |
author |
| author2 |
Ramírez, Cristina Gómez, Cristina Baldan-Martin, Montse Orejudo, Macarena Mercado, Jorge Chaparro Sánchez, María Pérez Gisbert, Francisco Javier |
| author2_role |
author author author author author author author |
| dc.contributor.none.fl_str_mv |
Departamento de Medicina Facultad de Medicina |
| dc.subject.none.fl_str_mv |
dendritic cell golimumab ustekinumab inflammatory bowel disease ulcerative colitis Crohn’s disease Medicina |
| topic |
dendritic cell golimumab ustekinumab inflammatory bowel disease ulcerative colitis Crohn’s disease Medicina |
| description |
Inflammatory bowel disease (IBD) is a chronic condition which includes ulcerative colitis (UC) and Crohn’s disease (CD), the origins of which are not yet fully understood. Both conditions involve an exacerbated immune response in the intestinal tract, leading to tissue inflammation. Dendritic cells (DCs) are antigen-presenting cells crucial for maintaining tolerance in the gastrointestinal mucosa. Previous research has indicated that DC recruitment to the intestinal mucosa is more pronounced in individuals with IBD, but the specific mechanisms governing this migration remain unclear. This study aimed to assess the expression of various homing markers and the migratory abilities of circulating DC subsets in response to intestinal chemotactic signals. Additionally, this study examined how golimumab and ustekinumab impact these characteristics in individuals with IBD compared to healthy controls. The findings revealed that a particular subset of DCs known as type 2 conventional DCs (cDC2) displayed a more pronounced migratory profile compared to other DC subsets. Furthermore, the study observed that golimumab and ustekinumab had varying effects on the migratory profile of cDC1 in individuals with CD and UC. While CCL2 did not exert a chemoattractant effect on DC subsets in this patient cohort, treatment with golimumab and ustekinumab enhanced their migratory capacity towards CCL2 and CCL25 while reducing their migration towards MadCam1. In conclusion, this study highlights that cDC2 exhibits a heightened migratory profile towards the gastrointestinal mucosa compared to other DC subsets. This finding could be explored further for the development of new diagnostic biomarkers or the identification of potential immunomodulatory targets in the context of IBD |
| publishDate |
2023 |
| dc.date.none.fl_str_mv |
2023 2023-10-18 |
| dc.type.none.fl_str_mv |
research article http://purl.org/coar/resource_type/c_2df8fbb1 VoR http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| dc.type.openaire.fl_str_mv |
info:eu-repo/semantics/article |
| format |
article |
| dc.identifier.none.fl_str_mv |
http://hdl.handle.net/10486/709409 https://dx.doi.org/10.3390/biomedicines11102831 |
| url |
http://hdl.handle.net/10486/709409 https://dx.doi.org/10.3390/biomedicines11102831 |
| dc.language.none.fl_str_mv |
Inglés eng |
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Inglés |
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eng |
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open access http://purl.org/coar/access_right/c_abf2 |
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info:eu-repo/semantics/openAccess |
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open access http://purl.org/coar/access_right/c_abf2 |
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openAccess |
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application/pdf |
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MDPI |
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MDPI |
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reponame:Biblos-e Archivo. Repositorio Institucional de la UAM instname:Universidad Autónoma de Madrid |
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Universidad Autónoma de Madrid |
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