Real-life experience with 4 years of golimumab persistence in ulcerative colitis patients

Golimumab has demonstrated its long-term efficacy and safety in ulcerative colitis in clinical trials, but no data of long-term persistence has been published from real world. To estimate long-term persistence of golimumab, as well as factors associated with longer persistence, in patients with ulce...

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Detalles Bibliográficos
Autores: Iborra, Marisa|||0000-0001-7360-7581, García-Morales, Natalia|||0000-0003-0130-3778, Rubio Iturria, Saioa, Bertoletti, Federico, Calvo, Marta, Taxonera, Carlos|||0000-0001-9166-7350, Bosca-Watts, Marta Maia|||0000-0001-7495-8797, Sierra Ausín, Mónica|||0000-0003-3342-8209, Manceñido, Noemí|||0000-0002-8089-9858, Beltrán, Belén|||0000-0002-7063-6376, Nantes Castillejo, Óscar|||0000-0002-3587-1039, García-Planella, Esther|||0000-0002-4325-0697, Vera-Mendoza, Isabel, Alba, Cristina, Martí-Aguado, David, Ballester, M.P., Cano-Sanz, Noelia, Pajares-Villarroya, Ramón, Cerrillo, Elena, Cañada, Antonio, Nos, Pilar|||0000-0002-6619-1511
Tipo de recurso: artículo
Fecha de publicación:2020
País:España
Institución:Universitat Autònoma de Barcelona
Repositorio:Dipòsit Digital de Documents de la UAB
Idioma:inglés
OAI Identifier:oai:ddd.uab.cat:283898
Acceso en línea:https://ddd.uab.cat/record/283898
https://dx.doi.org/urn:doi:10.1038/s41598-020-73577-0
Access Level:acceso abierto
Palabra clave:Crohn's disease
Inflammatory bowel disease
Ulcerative colitis
Descripción
Sumario:Golimumab has demonstrated its long-term efficacy and safety in ulcerative colitis in clinical trials, but no data of long-term persistence has been published from real world. To estimate long-term persistence of golimumab, as well as factors associated with longer persistence, in patients with ulcerative colitis in real life. Observational multicentre study including adult patients with ulcerative colitis treated with golimumab and with at least twelve months of follow-up. We included 190 patients, 105 (55.26%) naive to anti-TNF, with mean disease duration of 9.32 ± 8.09 years. Probability of persistence was 63%, 46%, 39% and 27% at 1, 2, 3 and 4 years, respectively. Persistence was lower in patients with primary failure to previous anti-TNF. Eighty-two (43.16%) patients needed dose intensification during follow-up, with a mean time until intensification of 8.03 ± 8.64 months. Dose intensification and lower disease duration predicted higher persistence with golimumab (p = 0.037 and p = 0.008, respectively). During a follow-up of 17.25 ± 15.83 months, 32 (16.5%) patients needed hospitalisation and 11 (6%) underwent colectomy. No unexpected adverse events were reported. Golimumab has demonstrated good persistence and safety profile for long treatment in ulcerative colitis patients.

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