Xerostomia and Salivary Flow in Patients Taking Antihypertensive Drugs

The aims of this systematic review are (1) to compare the prevalence of xerostomia and hyposalivation between patients taking antihypertensive drugs with a control group (CG), (2) to compare salivary flow rate between patients treated with a CG, and (3) to identify which antihypertensives produce xe...

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Detalles Bibliográficos
Autores: Ramírez Martínez-Acitores, Lucía, Hernández Ruiz de Azcárate, Fernando, Casañas, Elisabeth, Serrano Valle, Julia, Hernández Vallejo, Gonzalo, López-Pintor Muñoz, Rosa María
Tipo de recurso: artículo
Fecha de publicación:2020
País:España
Institución:Universidad Complutense de Madrid (UCM)
Repositorio:Docta Complutense
Idioma:inglés
OAI Identifier:oai:docta.ucm.es:20.500.14352/6619
Acceso en línea:https://hdl.handle.net/20.500.14352/6619
Access Level:acceso abierto
Palabra clave:Antihypertensives
Hypertension
Xerostomia
Hyposalivation
Salivary flow
Odontología (Medicina)
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spelling Xerostomia and Salivary Flow in Patients Taking Antihypertensive DrugsRamírez Martínez-Acitores, LucíaHernández Ruiz de Azcárate, FernandoCasañas, ElisabethSerrano Valle, JuliaHernández Vallejo, GonzaloLópez-Pintor Muñoz, Rosa MaríaAntihypertensivesHypertensionXerostomiaHyposalivationSalivary flowOdontología (Medicina)The aims of this systematic review are (1) to compare the prevalence of xerostomia and hyposalivation between patients taking antihypertensive drugs with a control group (CG), (2) to compare salivary flow rate between patients treated with a CG, and (3) to identify which antihypertensives produce xerostomia. This systematic review was carried out according to the preferred reporting items for systematic reviews and meta-analyses (PRISMA) guidelines. To evaluate methodological quality of the eligible studies Cochrane Collaboration tool for assessing the risk of bias for clinical trials and the modified Newcastle–Ottawa scale case-control studies were used. The databases were searched for studies up to November 19th 2019. The search strategy yielded 6201 results and 13 publications were finally included (five clinical trials and eight case-control studies). The results of the included studies did not provide evidence to state that patients taking antihypertensives suffer more xerostomia or hyposalivation than patients not taking them. With regard to salivary flow, only two clinical studies showed a significant decrease in salivary flow and even one showed a significant increase after treatment. The case–control studies showed great variability in salivary flow, but in this case most studies showed how salivary flow is lower in patients medicated with antihypertensive drugs. The great variability of antihypertensive drugs included, the types of studies and the outcomes collected made it impossible to study which antihypertensive drug produces more salivary alterations. The quality assessment showed how each of the studies was of low methodological quality. Therefore, future studies about this topic are necessary to confirm whether antihypertensive drugs produce salivary alterations.MDPIUniversidad Complutense de Madrid20202020-01-0120202020-01-01journal articlehttp://purl.org/coar/resource_type/c_6501info:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/20.500.14352/6619reponame:Docta Complutenseinstname:Universidad Complutense de Madrid (UCM)Inglésengopen accesshttp://purl.org/coar/access_right/c_abf2Atribución 3.0 Españahttps://creativecommons.org/licenses/by/3.0/es/info:eu-repo/semantics/openAccessoai:docta.ucm.es:20.500.14352/66192026-06-02T12:44:21Z
dc.title.none.fl_str_mv Xerostomia and Salivary Flow in Patients Taking Antihypertensive Drugs
title Xerostomia and Salivary Flow in Patients Taking Antihypertensive Drugs
spellingShingle Xerostomia and Salivary Flow in Patients Taking Antihypertensive Drugs
Ramírez Martínez-Acitores, Lucía
Antihypertensives
Hypertension
Xerostomia
Hyposalivation
Salivary flow
Odontología (Medicina)
title_short Xerostomia and Salivary Flow in Patients Taking Antihypertensive Drugs
title_full Xerostomia and Salivary Flow in Patients Taking Antihypertensive Drugs
title_fullStr Xerostomia and Salivary Flow in Patients Taking Antihypertensive Drugs
title_full_unstemmed Xerostomia and Salivary Flow in Patients Taking Antihypertensive Drugs
title_sort Xerostomia and Salivary Flow in Patients Taking Antihypertensive Drugs
dc.creator.none.fl_str_mv Ramírez Martínez-Acitores, Lucía
Hernández Ruiz de Azcárate, Fernando
Casañas, Elisabeth
Serrano Valle, Julia
Hernández Vallejo, Gonzalo
López-Pintor Muñoz, Rosa María
author Ramírez Martínez-Acitores, Lucía
author_facet Ramírez Martínez-Acitores, Lucía
Hernández Ruiz de Azcárate, Fernando
Casañas, Elisabeth
Serrano Valle, Julia
Hernández Vallejo, Gonzalo
López-Pintor Muñoz, Rosa María
author_role author
author2 Hernández Ruiz de Azcárate, Fernando
Casañas, Elisabeth
Serrano Valle, Julia
Hernández Vallejo, Gonzalo
López-Pintor Muñoz, Rosa María
author2_role author
author
author
author
author
dc.contributor.none.fl_str_mv Universidad Complutense de Madrid
dc.subject.none.fl_str_mv Antihypertensives
Hypertension
Xerostomia
Hyposalivation
Salivary flow
Odontología (Medicina)
topic Antihypertensives
Hypertension
Xerostomia
Hyposalivation
Salivary flow
Odontología (Medicina)
description The aims of this systematic review are (1) to compare the prevalence of xerostomia and hyposalivation between patients taking antihypertensive drugs with a control group (CG), (2) to compare salivary flow rate between patients treated with a CG, and (3) to identify which antihypertensives produce xerostomia. This systematic review was carried out according to the preferred reporting items for systematic reviews and meta-analyses (PRISMA) guidelines. To evaluate methodological quality of the eligible studies Cochrane Collaboration tool for assessing the risk of bias for clinical trials and the modified Newcastle–Ottawa scale case-control studies were used. The databases were searched for studies up to November 19th 2019. The search strategy yielded 6201 results and 13 publications were finally included (five clinical trials and eight case-control studies). The results of the included studies did not provide evidence to state that patients taking antihypertensives suffer more xerostomia or hyposalivation than patients not taking them. With regard to salivary flow, only two clinical studies showed a significant decrease in salivary flow and even one showed a significant increase after treatment. The case–control studies showed great variability in salivary flow, but in this case most studies showed how salivary flow is lower in patients medicated with antihypertensive drugs. The great variability of antihypertensive drugs included, the types of studies and the outcomes collected made it impossible to study which antihypertensive drug produces more salivary alterations. The quality assessment showed how each of the studies was of low methodological quality. Therefore, future studies about this topic are necessary to confirm whether antihypertensive drugs produce salivary alterations.
publishDate 2020
dc.date.none.fl_str_mv 2020
2020-01-01
2020
2020-01-01
dc.type.none.fl_str_mv journal article
http://purl.org/coar/resource_type/c_6501
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://hdl.handle.net/20.500.14352/6619
url https://hdl.handle.net/20.500.14352/6619
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
Atribución 3.0 España
https://creativecommons.org/licenses/by/3.0/es/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
Atribución 3.0 España
https://creativecommons.org/licenses/by/3.0/es/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv reponame:Docta Complutense
instname:Universidad Complutense de Madrid (UCM)
instname_str Universidad Complutense de Madrid (UCM)
reponame_str Docta Complutense
collection Docta Complutense
repository.name.fl_str_mv
repository.mail.fl_str_mv
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