Microbubble generation in a co-flow device operated in a new regime

A new regime of operation of PDMS-based flow-focusing microfluidic devices is presented. We show that monodisperse microbubbles with diameters below one-tenth of the channel width (here w = 50µm) can be produced in low viscosity liquids thanks to a strong pressure gradient in the entrance region of...

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Detalles Bibliográficos
Autores: Castro Hernández, Elena De, Hoeve, Wim Van, Lohse, Detlef, Gordillo Arias de Saavedra, José Manuel
Tipo de recurso: artículo
Estado:Versión aceptada para publicación
Fecha de publicación:2011
País:España
Institución:Universidad de Sevilla (US)
Repositorio:idUS. Depósito de Investigación de la Universidad de Sevilla
OAI Identifier:oai:idus.us.es:11441/158943
Acceso en línea:https://hdl.handle.net/11441/158943
https://doi.org/10.1039/c0lc00731e
Access Level:acceso abierto
Palabra clave:Flow rate
Article
Gas flow
Microbubble
Pressure gradient
Priority journal
Viscosity
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spelling Microbubble generation in a co-flow device operated in a new regimeCastro Hernández, Elena DeHoeve, Wim VanLohse, DetlefGordillo Arias de Saavedra, José ManuelFlow rateArticleGas flowMicrobubblePressure gradientPriority journalViscosityA new regime of operation of PDMS-based flow-focusing microfluidic devices is presented. We show that monodisperse microbubbles with diameters below one-tenth of the channel width (here w = 50µm) can be produced in low viscosity liquids thanks to a strong pressure gradient in the entrance region of the channel. In this new regime bubbles are generated at the tip of a long and stable gas ligament whose diameter, which can be varied by tuning appropriately the gas and liquid flow rates, is substantially smaller than the channel width. Through this procedure the volume of the bubbles formed at the tip of the gas ligament can be varied by more than two orders of magnitude. The experimental results for the bubble diameter db as function of the control parameters are accounted for by a scaling theory, which predicts db/w ∝ (µg/µℓ)1/12 (Qg/Qℓ )5/12 , where µg and µℓ indicate, respectively, the gas and liquid viscosities and Qg and Qℓ are the gas and liquid flow rates. As a particularly important application of our results we produce monodisperse bubbles with the appropriate diameter for therapeutical applications (db ≃5µm) and a production rate exceeding 105 Hz.Ministerio de Educación DPI2008-06624-C03-01Junta de Andalucía P08-TEP-03997Royal Society of ChemistryIngeniería Aeroespacial y Mecánica de FluidosTEP-103: Mecánica de fluidosMinisterio de Educación. EspañaJunta de Andalucía2011info:eu-repo/semantics/articleinfo:eu-repo/semantics/acceptedVersionapplication/pdfapplication/pdfhttps://hdl.handle.net/11441/158943https://doi.org/10.1039/c0lc00731ereponame:idUS. Depósito de Investigación de la Universidad de Sevillainstname:Universidad de Sevilla (US)InglésLab on a Chip, 11 (12), 2023-2029.DPI2008-06624-C03-01P08-TEP-03997https://pubs.rsc.org/en/content/articlelanding/2011/lc/c0lc00731einfo:eu-repo/semantics/openAccessoai:idus.us.es:11441/1589432026-06-17T12:51:07Z
dc.title.none.fl_str_mv Microbubble generation in a co-flow device operated in a new regime
title Microbubble generation in a co-flow device operated in a new regime
spellingShingle Microbubble generation in a co-flow device operated in a new regime
Castro Hernández, Elena De
Flow rate
Article
Gas flow
Microbubble
Pressure gradient
Priority journal
Viscosity
title_short Microbubble generation in a co-flow device operated in a new regime
title_full Microbubble generation in a co-flow device operated in a new regime
title_fullStr Microbubble generation in a co-flow device operated in a new regime
title_full_unstemmed Microbubble generation in a co-flow device operated in a new regime
title_sort Microbubble generation in a co-flow device operated in a new regime
dc.creator.none.fl_str_mv Castro Hernández, Elena De
Hoeve, Wim Van
Lohse, Detlef
Gordillo Arias de Saavedra, José Manuel
author Castro Hernández, Elena De
author_facet Castro Hernández, Elena De
Hoeve, Wim Van
Lohse, Detlef
Gordillo Arias de Saavedra, José Manuel
author_role author
author2 Hoeve, Wim Van
Lohse, Detlef
Gordillo Arias de Saavedra, José Manuel
author2_role author
author
author
dc.contributor.none.fl_str_mv Ingeniería Aeroespacial y Mecánica de Fluidos
TEP-103: Mecánica de fluidos
Ministerio de Educación. España
Junta de Andalucía
dc.subject.none.fl_str_mv Flow rate
Article
Gas flow
Microbubble
Pressure gradient
Priority journal
Viscosity
topic Flow rate
Article
Gas flow
Microbubble
Pressure gradient
Priority journal
Viscosity
description A new regime of operation of PDMS-based flow-focusing microfluidic devices is presented. We show that monodisperse microbubbles with diameters below one-tenth of the channel width (here w = 50µm) can be produced in low viscosity liquids thanks to a strong pressure gradient in the entrance region of the channel. In this new regime bubbles are generated at the tip of a long and stable gas ligament whose diameter, which can be varied by tuning appropriately the gas and liquid flow rates, is substantially smaller than the channel width. Through this procedure the volume of the bubbles formed at the tip of the gas ligament can be varied by more than two orders of magnitude. The experimental results for the bubble diameter db as function of the control parameters are accounted for by a scaling theory, which predicts db/w ∝ (µg/µℓ)1/12 (Qg/Qℓ )5/12 , where µg and µℓ indicate, respectively, the gas and liquid viscosities and Qg and Qℓ are the gas and liquid flow rates. As a particularly important application of our results we produce monodisperse bubbles with the appropriate diameter for therapeutical applications (db ≃5µm) and a production rate exceeding 105 Hz.
publishDate 2011
dc.date.none.fl_str_mv 2011
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/acceptedVersion
format article
status_str acceptedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/11441/158943
https://doi.org/10.1039/c0lc00731e
url https://hdl.handle.net/11441/158943
https://doi.org/10.1039/c0lc00731e
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Lab on a Chip, 11 (12), 2023-2029.
DPI2008-06624-C03-01
P08-TEP-03997
https://pubs.rsc.org/en/content/articlelanding/2011/lc/c0lc00731e
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Royal Society of Chemistry
publisher.none.fl_str_mv Royal Society of Chemistry
dc.source.none.fl_str_mv reponame:idUS. Depósito de Investigación de la Universidad de Sevilla
instname:Universidad de Sevilla (US)
instname_str Universidad de Sevilla (US)
reponame_str idUS. Depósito de Investigación de la Universidad de Sevilla
collection idUS. Depósito de Investigación de la Universidad de Sevilla
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15.301603

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