The polygenic basis of relapse after a first episode of schizophrenia

Segura À.-G.; Prohens L.; Gassó P.; Rodríguez N.; Garcia-Rizo C.; Moreno-Izco L.; Andreu-Bernabeu Á.; Zorrilla I.; Mane A.; Rodriguez-Jimenez R.; Roldán A.; Sarró S.; Ibáñez Á.; Usall J.; Sáiz P.A.; Cuesta M.J.; Parellada M.; González-Pinto A.; Berrocoso E.; Bernardo M.; Mas S.; Mezquida G.; Arbelo N.; De Matteis M.; Galvañ J.; Duque Guerra A.; Arias i Queralt L.; Perez-Bacigalupe M.; Gonzalez-Ortega I.; Toll A.; Casanovas F.; Sanchez-Pastor L.; Valtueña M.; Pomarol-Clotet E.; García-León M.Á.; Butjosa A.; Rubio-Abadal E.; Ribeiro M.; López-Ilundain J.M.; Saiz-Ruiz J.; León-Quismondo L.; Rivero O.; Ruiz P.; Echevarría R.S.; García-Portilla M.P.

The polygenic basis of relapse after a first episode of schizophrenia

Little is known about genetic predisposition to relapse. Previous studies have linked cognitive and psychopathological (mainly schizophrenia and bipolar disorder) polygenic risk scores (PRS) with clinical manifestations of the disease. This study aims to explore the potential role of PRS from major...

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Authors:	Segura À.-G., Prohens L., Gassó P., Rodríguez N., Garcia-Rizo C., Moreno-Izco L., Andreu-Bernabeu Á., Zorrilla I., Mane A., Rodriguez-Jimenez R., Roldán A., Sarró S., Ibáñez Á., Usall J., Sáiz P.A., Cuesta M.J., Parellada M., González-Pinto A., Berrocoso E., Bernardo M., Mas S., Mezquida G., Arbelo N., De Matteis M., Galvañ J., Duque Guerra A., Arias i Queralt L., Perez-Bacigalupe M., Gonzalez-Ortega I., Toll A., Casanovas F., Sanchez-Pastor L., Valtueña M., Pomarol-Clotet E., García-León M.Á., Butjosa A., Rubio-Abadal E., Ribeiro M., López-Ilundain J.M., Saiz-Ruiz J., León-Quismondo L., Rivero O., Ruiz P., Echevarría R.S., García-Portilla M.P.
Format:	article
Status:	Published version
Publication Date:	2023
Country:	España
Institution:	Institut d’Investigació Biomèdica Sant Pau (IIB Sant Pau)
Repository:	r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau
OAI Identifier:	oai:iibsantpau.fundanetsuite.com:p16658
Online Access:	https://iibsantpau.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=16658 https://www.scopus.com/inward/record.uri?eid=2-s2.0-85168388293&doi=10.1016%2fj.euroneuro.2023.06.003&partnerID=40&md5=3d97ef45d42acc88f21be4c2f207f89c
Access Level:	Open access
Keyword:	Cognition Polygenic risk score Relapse Schizophrenia

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spelling	The polygenic basis of relapse after a first episode of schizophreniaSegura À.-G.Prohens L.Gassó P.Rodríguez N.Garcia-Rizo C.Moreno-Izco L.Andreu-Bernabeu Á.Zorrilla I.Mane A.Rodriguez-Jimenez R.Roldán A.Sarró S.Ibáñez Á.Usall J.Sáiz P.A.Cuesta M.J.Parellada M.González-Pinto A.Berrocoso E.Bernardo M.Mas S.Mezquida G.Arbelo N.De Matteis M.Galvañ J.Duque Guerra A.Arias i Queralt L.Perez-Bacigalupe M.Gonzalez-Ortega I.Toll A.Casanovas F.Sanchez-Pastor L.Valtueña M.Pomarol-Clotet E.García-León M.Á.Butjosa A.Rubio-Abadal E.Ribeiro M.López-Ilundain J.M.Saiz-Ruiz J.León-Quismondo L.Rivero O.Ruiz P.Echevarría R.S.García-Portilla M.P.CognitionPolygenic risk scoreRelapseSchizophreniaLittle is known about genetic predisposition to relapse. Previous studies have linked cognitive and psychopathological (mainly schizophrenia and bipolar disorder) polygenic risk scores (PRS) with clinical manifestations of the disease. This study aims to explore the potential role of PRS from major mental disorders and cognition on schizophrenia relapse. 114 patients recruited in the 2EPs Project were included (56 patients who had not experienced relapse after 3 years of enrollment and 58 patients who relapsed during the 3-year follow-up). PRS for schizophrenia (PRS-SZ), bipolar disorder (PRS-BD), education attainment (PRS-EA) and cognitive performance (PRS-CP) were used to assess the genetic risk of schizophrenia relapse.Patients with higher PRS-EA, showed both a lower risk (OR=0.29, 95% CI [0.11-0.73]) and a later onset of relapse (30.96± 1.74 vs. 23.12± 1.14 months, p=0.007. Our study provides evidence that the genetic burden of neurocognitive function is a potentially predictors of relapse that could be incorporated into future risk prediction models. Moreover, appropriate treatments for cognitive symptoms appear to be important for improving the long-term clinical outcome of relapse.ELSEVIER2023info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttps://iibsantpau.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=16658https://www.scopus.com/inward/record.uri?eid=2-s2.0-85168388293&doi=10.1016%2fj.euroneuro.2023.06.003&partnerID=40&md5=3d97ef45d42acc88f21be4c2f207f89cEUROPEAN NEUROPSYCHOPHARMACOLOGYISSN: 0924977XISSNe: 18737862reponame:r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pauinstname:Institut d’Investigació Biomèdica Sant Pau (IIB Sant Pau)Inglésinfo:eu-repo/semantics/openAccessoai:iibsantpau.fundanetsuite.com:p166582026-06-14T12:41:47Z
dc.title.none.fl_str_mv	The polygenic basis of relapse after a first episode of schizophrenia
title	The polygenic basis of relapse after a first episode of schizophrenia
spellingShingle	The polygenic basis of relapse after a first episode of schizophrenia Segura À.-G. Cognition Polygenic risk score Relapse Schizophrenia
title_short	The polygenic basis of relapse after a first episode of schizophrenia
title_full	The polygenic basis of relapse after a first episode of schizophrenia
title_fullStr	The polygenic basis of relapse after a first episode of schizophrenia
title_full_unstemmed	The polygenic basis of relapse after a first episode of schizophrenia
title_sort	The polygenic basis of relapse after a first episode of schizophrenia
dc.creator.none.fl_str_mv	Segura À.-G. Prohens L. Gassó P. Rodríguez N. Garcia-Rizo C. Moreno-Izco L. Andreu-Bernabeu Á. Zorrilla I. Mane A. Rodriguez-Jimenez R. Roldán A. Sarró S. Ibáñez Á. Usall J. Sáiz P.A. Cuesta M.J. Parellada M. González-Pinto A. Berrocoso E. Bernardo M. Mas S. Mezquida G. Arbelo N. De Matteis M. Galvañ J. Duque Guerra A. Arias i Queralt L. Perez-Bacigalupe M. Gonzalez-Ortega I. Toll A. Casanovas F. Sanchez-Pastor L. Valtueña M. Pomarol-Clotet E. García-León M.Á. Butjosa A. Rubio-Abadal E. Ribeiro M. López-Ilundain J.M. Saiz-Ruiz J. León-Quismondo L. Rivero O. Ruiz P. Echevarría R.S. García-Portilla M.P.
author	Segura À.-G.
author_facet	Segura À.-G. Prohens L. Gassó P. Rodríguez N. Garcia-Rizo C. Moreno-Izco L. Andreu-Bernabeu Á. Zorrilla I. Mane A. Rodriguez-Jimenez R. Roldán A. Sarró S. Ibáñez Á. Usall J. Sáiz P.A. Cuesta M.J. Parellada M. González-Pinto A. Berrocoso E. Bernardo M. Mas S. Mezquida G. Arbelo N. De Matteis M. Galvañ J. Duque Guerra A. Arias i Queralt L. Perez-Bacigalupe M. Gonzalez-Ortega I. Toll A. Casanovas F. Sanchez-Pastor L. Valtueña M. Pomarol-Clotet E. García-León M.Á. Butjosa A. Rubio-Abadal E. Ribeiro M. López-Ilundain J.M. Saiz-Ruiz J. León-Quismondo L. Rivero O. Ruiz P. Echevarría R.S. García-Portilla M.P.
author_role	author
author2	Prohens L. Gassó P. Rodríguez N. Garcia-Rizo C. Moreno-Izco L. Andreu-Bernabeu Á. Zorrilla I. Mane A. Rodriguez-Jimenez R. Roldán A. Sarró S. Ibáñez Á. Usall J. Sáiz P.A. Cuesta M.J. Parellada M. González-Pinto A. Berrocoso E. Bernardo M. Mas S. Mezquida G. Arbelo N. De Matteis M. Galvañ J. Duque Guerra A. Arias i Queralt L. Perez-Bacigalupe M. Gonzalez-Ortega I. Toll A. Casanovas F. Sanchez-Pastor L. Valtueña M. Pomarol-Clotet E. García-León M.Á. Butjosa A. Rubio-Abadal E. Ribeiro M. López-Ilundain J.M. Saiz-Ruiz J. León-Quismondo L. Rivero O. Ruiz P. Echevarría R.S. García-Portilla M.P.
author2_role	author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author
dc.subject.none.fl_str_mv	Cognition Polygenic risk score Relapse Schizophrenia
topic	Cognition Polygenic risk score Relapse Schizophrenia
description	Little is known about genetic predisposition to relapse. Previous studies have linked cognitive and psychopathological (mainly schizophrenia and bipolar disorder) polygenic risk scores (PRS) with clinical manifestations of the disease. This study aims to explore the potential role of PRS from major mental disorders and cognition on schizophrenia relapse. 114 patients recruited in the 2EPs Project were included (56 patients who had not experienced relapse after 3 years of enrollment and 58 patients who relapsed during the 3-year follow-up). PRS for schizophrenia (PRS-SZ), bipolar disorder (PRS-BD), education attainment (PRS-EA) and cognitive performance (PRS-CP) were used to assess the genetic risk of schizophrenia relapse.Patients with higher PRS-EA, showed both a lower risk (OR=0.29, 95% CI [0.11-0.73]) and a later onset of relapse (30.96± 1.74 vs. 23.12± 1.14 months, p=0.007. Our study provides evidence that the genetic burden of neurocognitive function is a potentially predictors of relapse that could be incorporated into future risk prediction models. Moreover, appropriate treatments for cognitive symptoms appear to be important for improving the long-term clinical outcome of relapse.
publishDate	2023
dc.date.none.fl_str_mv	2023
dc.type.none.fl_str_mv	info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion
format	article
status_str	publishedVersion
dc.identifier.none.fl_str_mv	https://iibsantpau.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=16658 https://www.scopus.com/inward/record.uri?eid=2-s2.0-85168388293&doi=10.1016%2fj.euroneuro.2023.06.003&partnerID=40&md5=3d97ef45d42acc88f21be4c2f207f89c
url	https://iibsantpau.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=16658 https://www.scopus.com/inward/record.uri?eid=2-s2.0-85168388293&doi=10.1016%2fj.euroneuro.2023.06.003&partnerID=40&md5=3d97ef45d42acc88f21be4c2f207f89c
dc.language.none.fl_str_mv	Inglés
language_invalid_str_mv	Inglés
dc.rights.none.fl_str_mv	info:eu-repo/semantics/openAccess
eu_rights_str_mv	openAccess
dc.publisher.none.fl_str_mv	ELSEVIER
publisher.none.fl_str_mv	ELSEVIER
dc.source.none.fl_str_mv	EUROPEAN NEUROPSYCHOPHARMACOLOGY ISSN: 0924977X ISSNe: 18737862 reponame:r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau instname:Institut d’Investigació Biomèdica Sant Pau (IIB Sant Pau)
instname_str	Institut d’Investigació Biomèdica Sant Pau (IIB Sant Pau)
reponame_str	r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau
collection	r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau
repository.name.fl_str_mv
repository.mail.fl_str_mv
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The polygenic basis of relapse after a first episode of schizophrenia

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